Does Polycystic Ovary Syndrome Itself Have Additional Effect on Apelin Levels?

Şilfeler, Dilek Benk; Gökçe, Cumali; Kurt, Raziye Keskin; Atilgan, Nigar Yilmaz; Öztürk, Oktay Hasan; Turhan, Ebru; Baloğlu, Ali

doi:10.1155/2014/536896

Cited by 7 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our laboratory, we repeatedly found that apelin concentration in follicular fluid and levels of apelin and its receptor APJ mRNA in granulosa cells are higher in PCOS patients than in healthy controls [52] (Figure 11). More conflicting data are, however, available for circulating apelin in PCOS women, with an almost equal number of authors reporting significantly lower [128,129,217], higher [196,218] or unchanged [216,219] levels compared to control women (Figure 11).…”

Section: Adipokines and Female Reproductive Pathologiesmentioning

confidence: 99%

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Estienne

Bongrani

Reverchon

et al. 2019

IJMS

125

112

View full text Add to dashboard Cite

It is well known that adipokines are endocrine factors that are mainly secreted by white adipose tissue. Their central role in energy metabolism is currently accepted. More recently, their involvement in fertility regulation and the development of some reproductive disorders has been suggested. Data concerning the role of leptin and adiponectin, the two most studied adipokines, in the control of the reproductive axis are consistent. In recent years, interest has grown about some novel adipokines, chemerin, visfatin, resistin and apelin, which have been found to be strongly associated with obesity and insulin-resistance. Here, we will review their expression and role in male and female reproduction in humans and animal models. According to accumulating evidence, they could regulate the secretion of GnRH (Gonadotropin-Releasing Hormone), gonadotropins and steroids. Furthermore, their expression and that of their receptors (if known), has been demonstrated in the human and animal hypothalamo-pituitary-gonadal axis. Like leptin and adiponectin, these novel adipokines could thus represent metabolic sensors that are able to regulate reproductive functions according to energy balance changes. Therefore, after investigating their role in normal fertility, we will also discuss their possible involvement in some reproductive troubles known to be associated with features of metabolic syndrome, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia and intra-uterine growth retardation in women, and sperm abnormalities and testicular pathologies in men.

show abstract

Section: Adipokines and Female Reproductive Pathologiesmentioning

confidence: 99%

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Estienne

Bongrani

Reverchon

et al. 2019

IJMS

125

112

View full text Add to dashboard Cite

show abstract

“…Altinkaya et al suggested that serum Apelin levels are lower in women with PCOS than in controls 32 . However, BenkSilfeler et al concluded that serum Apelin levels in lean PCOS patients were not significantly different from the control subjects 33 . In the current study, however, serum Apelin levels are significantly higher in PCOS women compared with controls.…”

Section: %-Specificity %mentioning

confidence: 95%

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Elhafez¹,

Mohamed²,

Elmouttaleb³

et al. 2020

Int Res J Pharm

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age. Most PCOS patients have a tendency to become obese and insulin resistant. Omentin-1 is an anti-inflammatory adipokine and plays a role in regulating insulin sensitivity. Apelin is a new adipokine which may be a key regulator in glucose and lipid metabolism and may be associated with insulin resistance. This study aimed to evaluate serum levels of Omentin-1 and Apelin to determine their association with obesity and IR in PCOS. A total of eighty subjects divided into four groups: Group I: 20 non-obese control (BMI< 30), Group II: 20 non-obese patient with PCOS (BMI< 30), Group III: 20 obese Control (BMI ≥ 30) and Group IV: 20 obese patient with PCOS (BMI ≥ 30). Serum levels of Insulin, Omentin-1 and Apelin were estimated by ELISA. Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) was calculated. Results showed a significant decrease in serum levels of Omentin-1 and increase in serum levels of Apelinin (non-obese and obese) PCOS groups when compared to their controls. Within PCOS groups there were significant negative correlations between Omentin-1 and both of HOMA-IR and BMI, while there were significant positive correlations between Apelin and both of BMI and HOMA-IR. In summary serum Omentin-1 and Apelin are directly correlated with IR and obesity in women with PCOS.

show abstract

“…Apelin levels were higher in nonobese PCOS patients, suggesting a compensatory mechanism for metabolic consequences of insulin resistance. Comparative results of studies showing lower serum apelin levels in PCOS have been obtained by several authors [ 73 – 76 ]. Different from Cekmez et al's study [ 69 ], lower serum concentrations of apelin were found in PCOS subjects by Altinkaya et al [ 75 ] with a positive correlation with BMI, insulin, HOMA-IR, triglyceride, and free testosterone, speculating that apelin can be used as a marker for insulin sensitivity.…”

Section: Physiology and Pathology Of Apelin In The Ovarymentioning

confidence: 99%

Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review

Kurowska

Barbe

Rozycka

et al. 2018

International Journal of Endocrinology

View full text Add to dashboard Cite

Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue. Thus, apelin is synthesized locally in the hypothalamus, pituitary, ovaries, and testis of many species and has autocrine and/or paracrine effects. Most research indicates that apelin has an inhibitory effect on gonadotropin secretion and participates in the direct regulation of steroidogenesis, cell proliferation, and apoptosis in gonads. The article summarizes also results of a series of recent studies on the effect of apelin on reproduction pathology, like polycystic ovarian syndrome, endometriosis, and ovarian cancer. Many of these pathologies are still in critical need of therapeutic intervention, and recent studies have found that apelin can be targets in reproductive pathological states.

show abstract

Does Polycystic Ovary Syndrome Itself Have Additional Effect on Apelin Levels?

Cited by 7 publications

References 21 publications

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review

Contact Info

Product

Resources

About