Does persistent anti-HBc positivity influence the prognosis of HBsAg-negative hepatocellular carcinoma? comparative outcomes of anti-Hbc positive versus anti-Hbc negative non-B non-C HCC

Law, Jia Hao; Tan, Jiajie; Wong, Kien Yee Michael; Ng, Wan Qi; Tan, Poh Seng; Bonney, Glenn Kunnath; Iyer, Shridhar Ganpathi; Madhavan, Krishnakumar; Kow, Wei Chieh Alfred

doi:10.1016/j.hpb.2018.07.012

Cited by 3 publications

(2 citation statements)

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“…Our results confirmed that hepatitis B core antibody-positive was the evidence of HBV infection and a dangerous mark for all OBI patients, similar to other reports (Cacciola et al, 1999;Fattovich et al, 2008;Matsue et al, 2010;Coppola et al, 2014Coppola et al, , 2016Lee et al, 2015;Law et al, 2019;Qu et al, 2019;Suzuki et al, 2019). Furthermore, our findings showed that the mean maximum tumor diameter of the HBsAb Seropositivity Group was significantly smaller than that of the HBsAb Seronegative Group.…”

Section: Discussionsupporting

confidence: 92%

The Serious Challenge of Occult Hepatitis B Virus Infection-Related Hepatocellular Carcinoma in China

Xia

Peng

et al. 2022

Front. Microbiol.

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BackgroundIt is unknown how many people in China have chronic occult hepatitis B virus (HBV) infection (OBI) [chronic HBV infection with negative serum hepatitis B surface antigen (HBsAg) (N-HBsAg)]. Their clinical and virological characteristics, especially the correlation between the OBI and hepatocellular carcinoma (HCC), are still elusive and need to be investigated, including prevention, early diagnosis, and treatment strategies.Methods138 patients with HCC related to OBI were screened from 698 patients of HCC associated with HBV infection, their characteristics of epidemiology, clinical, biochemistry, virology, diagnostics, and therapeutics were analyzed retrospectively. Furthermore, the correlation between virological features and clinical features was investigated.ResultsIt was found that 19.8% (138/698) of patients with HBV-related HCC were OBI, of which 79.7% (110/138) were men, and 20.3% (28/138) were women. Most of the patients with OBI-related HCC were older men, and the median age was 63.2 years. In total 78.3% (108/138) of the patients had apparent right upper abdomen discomfort and/or pain and then sought medical examination, while 21.7% (30/138) of the patients were identified by health examination. A total of 10.9% (15/138) of the patients were admitted with chronic infection of HBV, and 2.2% (3/138) of the patients were admitted with a family history of hepatitis B. The alpha-fetoprotein (AFP) serum-positive rate was 39.1% (54/138). Tumor lesions >5.0 cm, with intrahepatic and/or extrahepatic metastasis, were found in 72.5% (100/138) of the patients. The diameter of the tumor in the Group of hepatitis B core antibody-positive [HBcAb(+)] and hepatitis B surface antibody-positive [HBsAb(+)] was 7.03 ± 3.76 cm, which was much smaller than 8.79 ± 4.96 cm in the Group of HBcAb(+) and HBsAb(−) (P = 0.035).ConclusionIt is estimated that at least 21 million OBI patients live in China. HBcAb(+) was not only the evidence of chronic HBV infection but also a dangerous mark for surface antigen-negative patients. A semi-annual or annual medical checkup is essential for all OBI patients to identify HCC as early as possible. The hypothesis underlying our analysis was that hepatitis B surface antibody would prevent the progress of HCC and facilitate the clearance of HBV in patients with OBI. Thereby, the hepatitis B vaccine could be used to prevent severe disease consequences.

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Section: Discussionsupporting

confidence: 92%

The Serious Challenge of Occult Hepatitis B Virus Infection-Related Hepatocellular Carcinoma in China

Xia

Peng

et al. 2022

Front. Microbiol.

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“…8 Without the alert of virus markers, most NBNC HCC cases do not have periodic medical examinations and are diagnosed at an advanced stage. 5,9 Ultrasonography (US), computed tomography (CT) and magnetic resonance (MR) have been used for diagnosis, but these techniques are dependent on the quality of the equipment and expertise of the operator. Some people could not be examined for their own reasons, such as allergy to the contrast.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Serum Biomarkers for Patients Undergoing Curative Resection with Non-B, Non-C Hepatocellular Carcinoma

Chen

2020

J Coll Physicians Surg Pak

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Isolated anti-HBc is an independent risk factor for tumor recurrence in intrahepatic cholangiocarcinoma after curative resection

Chen²,

Yang³

et al. 2022

Hepatobiliary & Pancreatic Diseases International

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Does persistent anti-HBc positivity influence the prognosis of HBsAg-negative hepatocellular carcinoma? comparative outcomes of anti-Hbc positive versus anti-Hbc negative non-B non-C HCC

Abstract: Isolated anti-HBc seropositivity in HbsAg negative patients tend to present incidentally with delayed diagnoses resulting in larger tumors, but their long-term survival remain comparable.

Cited by 3 publications

References 21 publications

The Serious Challenge of Occult Hepatitis B Virus Infection-Related Hepatocellular Carcinoma in China

The Serious Challenge of Occult Hepatitis B Virus Infection-Related Hepatocellular Carcinoma in China

Diagnostic Value of Serum Biomarkers for Patients Undergoing Curative Resection with Non-B, Non-C Hepatocellular Carcinoma

Isolated anti-HBc is an independent risk factor for tumor recurrence in intrahepatic cholangiocarcinoma after curative resection

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