Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study

Jones, Judith A.; Miller, Donald R.; Wehler, Carolyn J.; Rich, Sharron; Kaye, Elizabeth Krall; McCoy, Linda C.; Christiansen, Cindy L.; Rothendler, James A.; García, Raúl I.

doi:10.1111/j.1600-051x.2006.01002.x

Cited by 160 publications

(166 citation statements)

References 28 publications

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“…Our previous study also showed the beneficial effect of periodontal therapy on diabetes with acceptable glycemic control (HbA1c between 6.5% and 7.5%) (13), in contrast to the studies of Jones et al (14) and Lalla et al (15).…”

Section: Introductioncontrasting

confidence: 53%

“…These findings indicate that inflammation is involved in the pathogenesis of IR and T2DM, which is regarded as key processes in the mechanism of T2DM (8). However, Jones et al indicated that periodontal therapy has no statistically significant effect on glycemic control (14). This could be attributed to considerable differences in methodology, sample sizes and composition of the groups included in the studies.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

et al. 2011

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Objective To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. Methods and Patients A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patients with periodontitis were randomly divided into two groups according to whether they underwent periodontal intervention: T2DM-NT and T2DM-T group. The levels of serum adiponectin, C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), lipid profile, glucose, insulin, homeostasis model of assessment -insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were measured at baseline and after 3 months. Results The levels of clinical periodontal variables, the probing depth, attachment loss, bleeding index, and plaque index were improved significantly in T2DM-T group after 3 months compared to T2DM-NT group (all p<0.01). After 3 months, the serum levels of hsCRP, TNF-α, IL-6, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and HOMA-IR index decreased, and adiponectin was significantly increased in T2DM-T group compared to those in the T2DM-NT group (p<0.05 or p<0.01). Conclusion Periodontal intervention can improve glycemic control, lipid profile and IR, reduce serum inflammatory cytokine levels and increase serum adiponectin levels in moderately poorly controlled T2DM patients.

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Section: Introductioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

et al. 2011

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“…Intervention studies of the effect of nonsurgical periodontal treatment in diabetic patients generally show improved periodontal status, while results concerning changes in glycemic status are rather contradictory. Some found significant improvements in glycemic control (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19); others did not (20)(21)(22)(23)(24)(25)(26). Meta-analyses of intervention studies indicate a need for additional trials to clarify this relationship (27)(28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA<sub>1c </sub>

Kaur

Narula

Rajput

et al. 2015

Journal of Oral Science

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Abstract:We evaluated the effects of nonsurgical periodontal therapy in 100 patients with type 2 diabetes and chronic periodontitis. The participants were classified as having good (n = 48) or poor (n = 52) glycemic control and were further randomly allocated to receive either scaling and root planning treatment group or no treatment (n = 50 each). The effect of nonsurgical periodontal therapy was compared among diabetic patients with good glycemic control, those with poor glycemic control, and 25 nondiabetic individuals. Periodontal and metabolic status was recorded at baseline, 3 months, and 6 months. In patients receiving treatment, periodontal parameters significantly improved and HbA 1c decreased by 10.8%. Improvements in gingival index and bleeding on probing were greater in the nondiabetic participants and the treated patients with good glycemic control than in the treated patients with poor glycemic control (P < 0.05). Regression analysis showed that improvement in periodontal status was independently associated with glycemic improvement. Nonsurgical periodontal therapy improved glycemic control and periodontal health in patients with type 2 diabetes. However, patients with poor baseline glycemic control had less clinical improvement than did those without diabetes and those with good glycemic control. (J Oral Sci 57, 201-211, 2015)

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“…Several studies showed that periodontal treatment significantly improved glycemic conditions (22)(23)(24)(25). A recent meta-analysis of the efficacy of periodontal treatment on glycemic control in diabetic patients suggested that such treatment could lead to significant reductions in HbA1c (26).…”

Section: Effects Of Periodontal Treatment On Diabetesmentioning

confidence: 99%

Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle

et al. 2010

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Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study

Abstract: No significant benefit was found for periodontal therapy after 4 months in this study; trends in some results were in favour of periodontal treatment.

Cited by 160 publications

References 28 publications

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA<sub>1c </sub>

Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle

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