Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?

Qvick, Alvida; Sorbe, Bengt; Helenius, Gisela; Karlsson, Mats G.; Lillsunde-Larsson, Gabriella

doi:10.1007/s12032-017-0893-6

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Over-expression of both DNMT3A and DNMT3B was associated with an increased risk of vulvar local recurrence (univariate HR 4.51 (95% CI 1.40, 14.49), HR 5.69 (95% CI 1.17, 27.57) respectively) [32]. Furthermore, Qvick et al reported on the prognostic value of p53 codon 72 polymorphism [33]. A similar local recurrence rate in tumors with arg/arg genotype and in tumors with arg/pro or pro/pro genotype was observed.…”

Section: Remaining Factorsmentioning

confidence: 99%

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review

Grootenhuis

Pouwer

Bock

et al. 2018

Gynecologic Oncology

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Section: Remaining Factorsmentioning

confidence: 99%

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review

Grootenhuis

Pouwer

Bock

et al. 2018

Gynecologic Oncology

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“…Recently, a large number of studies have investigated the association between TP53 codon 72 polymorphisms and BC, including mechanism research, cancer susceptibility and prognosis 22 , 44 , 51 . As reported by Kung, increased growth arrest and decreased apoptosis were found in R72 cells compared with P72 cells.…”

Section: Discussionmentioning

confidence: 99%

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status

et al. 2018

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Background: Various studies had explored the relationship between TP53 codon 72 polymorphisms and the risk of bladder cancer (BC). However, their results remained inconsistent and the definite role of smoking or tumor status associated with this polymorphism in BC cases was seldom involved. Hence, this meta-analysis was to disclose such associations.Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science were conducted to obtain eligible studies, up to May 30th, 2018. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were utilized to assess the associations between TP53 codon 72 polymorphisms and BC susceptibilities under five genetic comparison models.Results: Ultimately, this meta-analysis enrolled 22 applicable studies with 3,791 BC cases and 4,917 controls. Our results suggested that the variant genotypes were associated with BC risk in Asian subgroup (allele model: OR=1.19, 95% CI=1.04-1.34; dominant model: OR=1.27, 95% CI=1.06-1.52; homozygote model: OR=1.36, 95% CI=1.03-1.80), while negative outcomes were presented in Caucasians. In the relationship between TP53 codon 72 polymorphisms and BC tumor stage in Asian group, positive results were presented in allele model: OR=1.68, 95% CI=1.04-2.72; dominant model: OR=2.46, 95% CI=1.08-5.61; heterozygous model: OR=2.32, 95% CI=1.04-5.14; homozygote model: OR=2.66, 95% CI=1.04-6.81. However, no evidence was revealed between this polymorphism and BC tumor grade. Besides, significant associations were displayed between TP53 codon 72 polymorphism and smoking status (allele model: OR=1.40, 95% CI=1.06-1.84; dominant model OR=1.72, 95% CI=1.18-2.50; heterozygous model: OR=1.77, 95% CI=1.19-2.64).Conclusion: Taken together, our results shed light on that TP53 codon 72 polymorphism was significantly associated with the susceptibility to BC in Asians. In addition, positive associations were also revealed between this polymorphism and tumor stage/smoking status in BC cases.

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“…Indeed, in several HPV-related cancers (e.g. oral cancer, cervical cancer, vulvar and vaginal carcinoma) disease risk was shown to be influenced by the p53 p.Arg72Pro SNP 17 - 19 suggesting the p.72Arg variant as a risk factor for cancer development in high risk HPV positive individuals. But also in non HPV-related tumor types p53 codon 72 SNP was shown to influence disease risk 20 - 22 .…”

Section: Introductionmentioning

confidence: 99%

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

et al. 2018

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Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. The p53 p.Arg72 variant was described as a risk factor for developing a malignancy in combination with the presence of HPV as the p.72Arg variant is more prone to HPV E6 protein-mediated degradation than the p.72Pro variant. For penile carcinoma there are only sparse data available on this topic. We therefore analyzed the distribution of this p53 codon 72 SNP in a cohort of 107 penile cancer patients and a healthy control group (n=194) using Restriction Fragment Length Polymorphism (RFLP) analysis. After DNA isolation a PCR amplicon including the variant nucleotide was generated. Based on the variant nucleotide this amplicon can be cleaved into two parts or remain unaffected by a restriction enzyme. Subsequent electrophoresis allowed the discrimination of SNP alleles in the investigated sample. Comparison of the allelic variants revealed no significant differences in the distribution of this SNP between cases and controls (p=0,622). There was also no difference in SNP distribution between cases with/without HPV infection (p=0,558) or histologic variants (p=0.339). In order to strengthen the impact of our data we performed a combined analysis of all published data on this topic with our results. This ended up in SNP distribution data from 177 cases and 1149 controls. Overall, there were also no significant differences in the allelic distribution of the p53 codon 72 SNP between either cases and controls (p=0,914) or HPV-positive and HPV-negative cases (p=0,486). From this most comprehensive data available to date we conclude that there is no influence of the p53 codon 72 SNP on the risk of development of penile carcinoma in Caucasians even in the presence of HPV.

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Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?

Cited by 5 publications

References 39 publications

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

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