Does Oxidative Stress Induced by Alcohol Consumption Affect Orthodontic Treatment Outcome?

Abstract

HIGHLIGHTS Ethanol, Periodontal ligament, Extracellular matrix, Orthodontic movement.Alcohol is a legal drug present in several drinks commonly used worldwide (chemically known as ethyl alcohol or ethanol). Alcohol consumption is associated with several disease conditions, ranging from mental disorders to organic alterations. One of the most deleterious effects of ethanol metabolism is related to oxidative stress. This promotes cellular alterations associated with inflammatory processes that eventually lead to cell death or cell cycle arrest, among others. Alcohol intake leads to bone destruction and modifies the expression of interleukins, metalloproteinases and other pro-inflammatory signals involving GSKβ, Rho, and ERK pathways. Orthodontic treatment implicates mechanical forces on teeth. Interestingly, the extra- and intra-cellular responses of periodontal cells to mechanical movement show a suggestive similarity with the effects induced by ethanol metabolism on bone and other cell types. Several clinical traits such as age, presence of systemic diseases or pharmacological treatments, are taken into account when planning orthodontic treatments. However, little is known about the potential role of the oxidative conditions induced by ethanol intake as a possible setback for orthodontic treatment in adults.

Оптимизация Сбора Анамнеза На Ортодонтическом Приеме

“…Хорошо известна прямая зависимость между курением и снижением минеральной плотности кости и воспалительными заболеваниями пародонта. Аналогичным побочным действием в отношении костной ткани обладает и этанол [24,25].…”

Evaluation of Varied Modalities of Tocotrienol Supplementations to Counter the Cerebellar Oxidative Stress Caused by Low-to-moderate Doses of Ethanol in Rats

“…[44] Acetaldehyde could be produced from Et by -(a) catalase mediated pathway at the peroxisomes, (b) cytochrome P4502E1 mediated pathway at the microsomes and (c) alcohol dehydrogenase at the cytosol. [28,45] Catalase needs H 2 O 2 for this activity whereas H 2 O 2 itself is a substrate for catalase. [28,46] Conversion of H 2 O 2 into water as well as Et into acetaldehyde are the functions of peroxisomal catalase and nearly half of the brain Et load is metabolized by it.…”

Еxperimental justification of the efficacy of cocarnite for correction of disorders in rat periodont tissues under alcohol neuropathy

“…Отже, етанол-індукована полінейропатія викликає розвиток оксидативного стресу у м'яких тканинах пародонта, що підтверджується іншими дослідниками, які вивчали вплив етанолу на окисно-відновлювальні процеси в органах порожнини рота тварин [29,30]. Введення Кокарніту запобігало розвиткові оксидативного стресу у щурів за умов АПН, про що свідчить вірогідне зменшення вмісту ТБК-активних продуктів, молекул середньої маси та ОМБ порівняно з тваринами, яким моделювали алкогольну нейропатію без корекції (табл.…”