Does Obesity Increase the Risk of Miscarriage in Spontaneous Conception: A Systematic Review

Boots, Christina E.; Stephenson, Mary D.

doi:10.1055/s-0031-1293204

Cited by 299 publications

(150 citation statements)

References 29 publications

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“…Obesity is known to have an impact on the hypothalamic-pituitary ovarian axis, and on oocyte, embryo and endometrial development, including implantation [30], with larger women being shown to have a higher miscarriage rate compared to woman with a normal BMI [7]. PCOS is more common in obese patients.…”

Section: Discussionmentioning

confidence: 99%

“…Overweight or obese women are more likely to suffer from oligomenorrhoea. They have also been shown to have a higher risk of miscarriage than the background population; a miscarriage rate of 13.7% has been documented in obese women, compared to 10.9% in women with a normal BMI [7]. The recurrent miscarriage rate has also been speculated to be increased in obese women, however, a recent systematic review has not confirmed this [7].…”

Section: Bmi and Natural Conceptionmentioning

confidence: 99%

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The Impact of Body Mass Index on Assisted Reproductive Treatments

Supramaniam¹,

Mittal²,

Lim³

2017

OJOG

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Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m 2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.

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Section: Discussionmentioning

confidence: 99%

Section: Bmi and Natural Conceptionmentioning

confidence: 99%

The Impact of Body Mass Index on Assisted Reproductive Treatments

Supramaniam¹,

Mittal²,

Lim³

2017

OJOG

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“…Проблема не только забеременеть, но и выносить беременность. Согласно систематиче-скому обзору мета-анализа исследования по проблеме ожирения и риска самопроизвольного выкидыша, оказалось, что среди женщин, забеременевших спон-танно, частота риска возникновения выкидыша у женщин с ожирением выше, чем у женщин с нор-мальным весом [21]. По данным мета-анализа 2015 г. выявлено, что риск осложнений беременности повы-шается по мере увеличения ИМТ.…”

Section: влияние ожирения на репродукциюunclassified

“…Протеомный анализ образцов эндометрия у пациенток с различной массой тела показал нарушение экспрессии лейкемие-инте-грирующего фактора и гаптоглобина, что может объ-DOI: 10.14341/OMET2017416-22 Ожирение и метаболизм. 2017;14(4): [16][17][18][19][20][21][22] О б з о р ы л и т е р а т у р ы яснить высокую частоту прерывания беременности на раннем сроке [38]. В работах других авторов выяв-лена положительная корреляция между повышенным ИМТ и увеличением толщины эндометрия, что также может влиять на изменение его рецептивности [39].…”

Section: ожирение как предиктор неудач в программах вспомогательных рunclassified

Obesity, reproduction and oxidative stress

2017

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The prevalence of obesity and overweight is one of the most pressing problems nowadays. Obesity as a comorbid condition affects all body systems. Obesity has been reported to be a risk factor not only for cardiovascular diseases and oncopathology, but also for fertility problems, many obstetric and perinatal complications worsening the maternal and infant health. The balance between the oxidative and antioxidant system is one of the indicators of the state of human homeostasis. Today it is proved that obesity is associated with an increase in oxidative stress and a decrease in antioxidant protection. This review reveals a close relationship between obesity, oxidative stress and reproductive problems.

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“…Obesity is associated with many endocrine disorders, such as diabetes, hypothyroidism, and PCOS, which theoretically could result in an increased risk of euploid miscarriage due to suboptimal implantation related to endocrine changes. [83] completed a systematic review evaluating whether obesity increases the rate of miscarriage in spontaneously conceived pregnancies. The odds of having RM were increased for obese women (odds ratio [OR] 1.31, 95% CI 1.18-1.46) and overweight women (OR 1.11, 95% CI 1.00-1.24), when compared with women with normal BMI.…”

Section: Hormonal and Metabolic Etiologymentioning

confidence: 99%

Recurrent Miscarriage: A Review

Barrenetxea¹

2017

RMGO

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pregnancy events [2]. Clinical miscarriages may be subdivided into early clinical pregnancy losses (before gestational week 12) and late clinical pregnancy losses (gestational weeks 12 to 21). The term miscarriage is preferred rather than abortion both by patients and physicians, although "spontaneous abortion" is still used in scientific literature [3,4].For more than 30 years, controversy has existed on the number of miscarriages required to define RM and when diagnostic testing is warranted [5] EpidemiologyEarly pregnancy loss is perhaps the most common obstetric complication, occurring in over two-thirds of human conceptions. Approximately 15 -20% of all clinically recognized pregnancies will end in a miscarriage [4,9,10]. However, prospective cohort studies using sensitive and specific daily urinary hCG assays in women trying to conceive have demonstrated that only around one-third of conceptions progress to a live birth. Most of the losses occur before the clinical recognition of pregnancy as implantation failures. An estimated 30% of human conceptions are lost prior to implantation and a further 30% following implantation but before the missed menstrual period, that is in the third or fourth week of gestation. These are often termed preclinical losses [11].The risk of sporadic miscarriage between 6 and 12 weeks of gestation in women less than 35 years of age is 9% to 12%. The risk increases with age. In women older than 40 years of age, the sporadic miscarriage rate approaches 50%. Late losses between 12 and 22 weeks occur less frequently and constitute around 4% of pregnancy outcomes [4,9].Compared to sporadic miscarriage the prevalence of RM is considerably lower irrespective of whether biochemical losses are included or not. Approximately 1% of all women trying to conceive have recurrent miscarriage, defined as three previous miscarriages; when recurrent miscarriage is defined as two previous miscarriages, the proportion rises to 3% [12,13]. EtiologyMultiple potential etiologies for RM have been described (Table 1). As a consequence, several recommendations have been published regarding the evaluation and management of RM [3].The potential etiologies of RM can be divided into embryologically driven causes (mainly due to an abnormal embryonic karyotype) and maternally driven causes which affect the endometrium and/or placental development [14,15]. Thus, studies that focus on RM have Barrenetxea G, et al., J Reprod Med Gynecol Obstet 2017 AbstractHuman reproduction is characterized by its inefficiency. The loss of pregnancy at any stage can be a devastating experience and particular sensitivity is required in assessing and counseling couples with Recurrent Miscarriage (RM). Recurrent Miscarriage (RM) represents a clinical challenge for physicians not only because there are multiple possible etiologies, but also because the diagnostic testing is costly and time consuming. Despite several well-known etiologic factors, the cause of RM cannot be determined in almost 50% of cases. Multiple potential etiolo...

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Does Obesity Increase the Risk of Miscarriage in Spontaneous Conception: A Systematic Review

Cited by 299 publications

References 29 publications

The Impact of Body Mass Index on Assisted Reproductive Treatments

The Impact of Body Mass Index on Assisted Reproductive Treatments

Obesity, reproduction and oxidative stress

Recurrent Miscarriage: A Review

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