Does nuchal translucency thickness in the first trimester predict GDM onset during pregnancy?

Luchi, Carlo; Schifano, Martina; Nanini, Chiara; Cianni, Graziano Di; Lencioni, Cristina; Genazzani, Andrea Riccardo

doi:10.3109/09513590.2010.538101

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…34,35 Kelekci 12 found enlarged NT to be predictive of macrosomia in women with gestational diabetes, whereas two other studies did not. 36,37 The association between enlarged NT and macrosomia in non-diabetic pregnancies is thus far described by one large study 13 and confirmed by two smaller ones. 14,15 Poon 13 found a linear association between delta NT and birth weight, and delta NT was significantly larger in fetuses that were macrosomic at birth.…”

Section: Discussionmentioning

confidence: 75%

“…Some authors found lower PAPP‐A levels in case of maternal (gestational) diabetes but no association between NT and diabetes . Kelekci found enlarged NT to be predictive of macrosomia in women with gestational diabetes, whereas two other studies did not . The association between enlarged NT and macrosomia in non‐diabetic pregnancies is thus far described by one large study and confirmed by two smaller ones .…”

Section: Discussionmentioning

confidence: 95%

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High macrosomia rate in healthy fetuses after enlarged nuchal translucency

et al. 2014

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 95%

High macrosomia rate in healthy fetuses after enlarged nuchal translucency

et al. 2014

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“…Luchi ve ark. İlk trimester NT ölçümünün GDM öngörüsündeki rolünü araştırmışlardır ve sonuçların kontrol grubundan farklı olmadığını görmüşlerdir [17]. Bizim çalışmamızda da NT değeri iki grup arasında benzer bulunmuştur.…”

Section: Discussionunclassified

The Role of Biochemical Markers of First Trimester Trisomy Screening Test in the Prediction of Gestational Diabetes Mellitus

Abide

2018

Zeynep Kamil Tıp Bülteni

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ÖZET Amaç: Gebelere rutinde bakılan birinci trimester tarama testi biyokimyasal belirteçleri olan PAPP-A (Gebelik ilişkili plazma protein A) ve ßhcg değerlerinin, ilerleyen gebelik haftalarında gelişen gestasyonel diyabetes mellitus (GDM) hastalığının taranmasında ve erken tanısında ek maliyet yaratmadan faydalanabilme potansiyelini araştırmaktır. Gereçler veYöntem: Bu çalışma retrospektif kohort bir çalışma olarak planlandı. Çalışmaya Ocak 2014 -Aralık 2016 yılları arasında birinci trimester trizomi taraması hastanemizde yapılan ve rutin gebelik takibine alınıp doğumunu yine hastanemizde gerçekleştirmiş olan tekil gebeler dahil edilmiştir. Gebeler GDM ve kontrol grubu olarak iki gruba ayrılmıştır. Birinci trimester tarama testi biyokimyasal belirteçlerinin ( PAPP-A (MoM), ßhcg (MoM)) ilerleyen gebelik haftalarında ortaya çıkan GDM'nin tanısının daha erken konulmasında rolünün etkisi araştırılmıştır. Bulgular: GDM grubunda, kontrol grubuna göre, anne yaşı, gebelik sayısı, parite, abortus ve yaşayan çocuk sayısı anlamlı olarak yüksek bulunmuştur (p<0.05). GDM grubunda PAPP-A (MoM), ßhcg (MoM), NT (mm) ve NT (MoM), doğumun gerçekleştiği gestasyonel hafta, bebek doğum ağırlığı, APGAR 1.dk ve APGAR 5.dk değerleri arasında istatistiksel olarak anlamlı bir fark gözlenmemiştir. Sonuç: Çalışmada birinci trimester tarama testi biyokimyasal belirteçleri ile GDM arasında istatistiksel olarak anlamlı bir ilişki saptanmamıştır. Ancak bu konuda daha çok hasta sayısı ve özenle planlanmış prospektif çalışmalara ihtiyaç duyulmaktadır.Anahtar Kelimeler: birinci trimester tarama, gestasyonel diyabetes mellitus, gebelik ilişkili protein A, GDM ABSTRACT Objective: To investigate the potential advantage of routinely examined biochemical markers; PAPP-A (pregnancy related plasma protein A) and ßHCG values, in the first trimester screening test for the screening and early diagnosis of gestational diabetes mellitus (GDM) disease that occured in the following weeks of pregnancy without bringing any additional cost. Material and Methods:This study was designed as a retrospective cohort study. In this study singleton pregnancies were included whose first trimester trisomy screening tests were examined in our hospital and also deliviries of them took place in our hospital with the routine pregnancy follow up between January 2014 -December 2016. The pregnancies were divided into two groups as GDM and control group. The functional role of biochemical markers ( PAPP-A (MoM), ßhcg (MoM)) in the first trimester screening test were investigated for early diagnosis of GDM which appeared in the later gestational weeks of pregnancy.Results: In the GDM group; maternal age, the number of pregnancies, parity, abort and living children were found significantly high, according to the control group (p<0.05). Statistically significant difference was not observed between PAPP-A (MoM), ßhcg (MoM), NT (mm) ve NT (MoM), gestational week of delivery, birth infant weight, APGAR 1.minute and APGAR 5.minute in the GDM group. Conclusion: No statistically significant...

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“…La medida de la TN no parece asociarse al posterior desarrollo de DG 68,77 . Sin embargo, en fetos macrosómicos, la TN en el primer trimestre era mayor que en fetos con peso adecuado para la edad gestacional [71][72][73]75,76 .…”

Section: Marcadores Biofísicosunclassified

Cribado precoz de diabetes gestacional y macrosomía

Maíz

Plasencia

2014

Progresos de Obstetricia y Ginecología

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Recibido el 7 de julio de 2014; aceptado el 10 de julio de 2014 Disponible en Internet el 11 de septiembre de 2014 PALABRAS CLAVE Diabetes gestacional; Macrosomía fetal; Cribado; Primer trimestreResumen La diabetes gestacional (DG), con una prevalencia de un 9%, se asocia a una elevada morbilidad materna y perinatal. El diagnóstico y el tratamiento precoz de la hiperglucemia materna reducen el riesgo de macrosomía fetal y sus complicaciones intraparto. En el primer trimestre se puede identificar factores de riesgo de DG de la historia materna (edad, obesidad, macrosomía o DG en gestaciones previas, antecedente familiar de diabetes), marcadores bioquímicos (adiponectina, sex hormone-binding globuline y otros) y marcadores biofísicos (arteriografía, adiposidad visceral). Entre los factores de riesgo de macrosomía destacan la obesidad y la diabetes en la historia materna, pregnancy associated plasma protein-A y fracción libre de la subunidad beta de la gonadotropina coriónica humana como marcadores bioquímicos y la translucencia nucal y Doppler de arterias uterinas como marcadores biofísicos. Combinando los marcadores mediante modelos de predicción, y con una tasa de falsos positivos del 10%, se puede alcanzar una tasa de detección del 65 y el 35% para DG y macrosomía, respectivamente. ß 2014 SEGO. Publicado por Elsevier España, S.L.U. Todos los derechos reservados. Early screening of gestational diabetes and macrosomyAbstract Gestational diabetes (GD), which has a prevalence of 9%, is associated with high maternal and perinatal morbidity. Early diagnosis and treatment of maternal hyperglycemia reduce the risk of macrosomia and the associated intrapartum complications. Risk factors for GD can be identified in the first trimester from maternal history (age, obesity, previous macrosomia or GD, family history of diabetes), biochemical markers (adiponectin, sex hormone-binding globuline and others), and biophysical markers (arteriography, visceral adiposity). Risk factors for macrosomia include obesity and diabetes in the maternal history, pregnancy associated plasma protein-A and free b subunit of human chorionic gonadotropin as biochemical markers, and nuchal translucency and uterine artery Doppler as biophysical markers. Prediction models

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Does nuchal translucency thickness in the first trimester predict GDM onset during pregnancy?

Abstract: NT thickness does not show a significative increase in those women who subsequently develop GDM. Therefore, NT assessment does not prove to be an useful ultrasound parameter for predicting GDM onset during pregnancy.

Cited by 5 publications

References 21 publications

High macrosomia rate in healthy fetuses after enlarged nuchal translucency

High macrosomia rate in healthy fetuses after enlarged nuchal translucency

The Role of Biochemical Markers of First Trimester Trisomy Screening Test in the Prediction of Gestational Diabetes Mellitus

Cribado precoz de diabetes gestacional y macrosomía

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