High macrosomia rate in healthy fetuses after enlarged nuchal translucency

Timmerman, E.; Pajkrt, Eva; Snijders, R. J. M.; Bilardo, C. M.

doi:10.1002/pd.4262

Cited by 6 publications

(6 citation statements)

References 45 publications

(107 reference statements)

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“…Hackmon et al's study in 2017 showed a correlation between birth weight and early fetal measurements such as biparietal diameter (BPD) and crown-rump length (CRL), NT measurements, and NT percentiles (11). There is a predominant opinion in the literature that a correlation exists between LGA and NT measurements (2,10,13,27,30,31), but our study revealed no correlation between NT measurements and non-LGA AGA and SGA groups. Therefore, our data show that NT measurements within normal limits can be useful parameters for detecting future macrosomic or LGA fetuses.…”

Section: Discussioncontrasting

confidence: 65%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

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Section: Discussioncontrasting

confidence: 65%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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“…[12] Again, similarly, Timmerman et al also identified a positive correlation between NT MoM and birth weight and concluded that the increase in NT was associated with macrosomia. [13] Although Rinat et al reported that NT measurements were correlated with the birth weight of babies in the LGA and SGA in the general population, [14] other researchers reported that there were no such correlations between AGA babies and birth weight. [13] Poon et al reported that not only NT MoM values were effective in predicting macrosomia but also the combination of parameters and maternal characteristics that were used in the screening of aneuploidies were effective in predicting birth weight.…”

Section: Discussionmentioning

confidence: 98%

“…[13] Although Rinat et al reported that NT measurements were correlated with the birth weight of babies in the LGA and SGA in the general population, [14] other researchers reported that there were no such correlations between AGA babies and birth weight. [13] Poon et al reported that not only NT MoM values were effective in predicting macrosomia but also the combination of parameters and maternal characteristics that were used in the screening of aneuploidies were effective in predicting birth weight. [15] In another study conducted by the same author, it was reported that there was a linear relation between decreased NT and SGA.…”

Section: Discussionmentioning

confidence: 98%

Role of first trimester screening test in predicting the perinatal outcomes in low risk term pregnancies

Turan¹,

Turgut²,

Özdemir³

et al. 2022

Perinat J

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Objective: This study aims to investigate the relationship between the nuchal translucency (NT) values measured in the first trimester and the well-being of the newborn. Methods: The study was planned as a retrospective cross-sectional study and was conducted between January 2018 and January 2020. A total of 2394 patients who had a combined test and delivered at our university hospital were included in the study. The demographic data of the pregnant women were recorded. NT MoM values, PAPP-A and β-hCG MoM values, birth weight, gender, need for neonatal intensive care (NICU), and Apgar scores were evaluated. Results: It was found that NT (MoM) values were similar among the SGA, AGA, and LGA groups (p=0.159). PAPP-A (MoM) values were similar in the SGA group compared to AGA and LGA infant groups (p=0.947). It was also found that β-hCG (MoM) values were similar in the AGA group compared to SGA and the LGA infant groups (p=0.694). When compared with those with NICU and non-NICU, the NT, PAPP-A, β-hCG, and birth weight values were again not found to be statistically significant (p>0.05). The NT, PAPP-A, β-hCG, and male gender factors were evaluated in the Binary Logistic Regression Analysis, in which being an SGA baby was considered as a risk. It was found that a 1 mm increase in NT values increased the risk of having an SGA baby 2.63 times at a statistically significant level (OR=2.636, p=0.009, 95% CI: 1.277–5.440). PAPP-A, β-hCG levels, and having a male gender were not related to the risk of having an SGA baby. Furthermore, NT, PAPP-A, β-hCG levels, and having a male gender were not associated with the risk of NICU hospitalization. Conclusion: In conclusion, we could not predict the birth weight with increased NT MoM values that were detected in the first trimester combined test in this study; however, we found that the risk of having an SGA fetus increases with a weak rise in NT value.

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“…Sin embargo, en fetos macrosómicos, la TN en el primer trimestre era mayor que en fetos con peso adecuado para la edad gestacional [71][72][73]75,76 .…”

Section: Marcadores Biofísicosunclassified

“…Los modelos de predicción de macrosomía incluyen factores de la historia clínica materna, como edad, peso, talla, raza, antecedente de feto macrosómico, tabaquismo, diabetes mellitus e hipertensión crónica, marcadores biofísicos como la TN y el IP medio de arterias uterinas, y marcadores bioquímicos como la PAPP-A y la b-hCG libre en sangre materna, obteniendo tasas de detección alrededor de un 35 y un 20% para tasas de falsos positivos del 10 y el 5%, respectivamente 33,[71][72][73]76 .…”

Section: Modelos De Predicciónunclassified

Cribado precoz de diabetes gestacional y macrosomía

Maíz

Plasencia

2014

Progresos de Obstetricia y Ginecología

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Recibido el 7 de julio de 2014; aceptado el 10 de julio de 2014 Disponible en Internet el 11 de septiembre de 2014 PALABRAS CLAVE Diabetes gestacional; Macrosomía fetal; Cribado; Primer trimestreResumen La diabetes gestacional (DG), con una prevalencia de un 9%, se asocia a una elevada morbilidad materna y perinatal. El diagnóstico y el tratamiento precoz de la hiperglucemia materna reducen el riesgo de macrosomía fetal y sus complicaciones intraparto. En el primer trimestre se puede identificar factores de riesgo de DG de la historia materna (edad, obesidad, macrosomía o DG en gestaciones previas, antecedente familiar de diabetes), marcadores bioquímicos (adiponectina, sex hormone-binding globuline y otros) y marcadores biofísicos (arteriografía, adiposidad visceral). Entre los factores de riesgo de macrosomía destacan la obesidad y la diabetes en la historia materna, pregnancy associated plasma protein-A y fracción libre de la subunidad beta de la gonadotropina coriónica humana como marcadores bioquímicos y la translucencia nucal y Doppler de arterias uterinas como marcadores biofísicos. Combinando los marcadores mediante modelos de predicción, y con una tasa de falsos positivos del 10%, se puede alcanzar una tasa de detección del 65 y el 35% para DG y macrosomía, respectivamente. ß 2014 SEGO. Publicado por Elsevier España, S.L.U. Todos los derechos reservados. Early screening of gestational diabetes and macrosomyAbstract Gestational diabetes (GD), which has a prevalence of 9%, is associated with high maternal and perinatal morbidity. Early diagnosis and treatment of maternal hyperglycemia reduce the risk of macrosomia and the associated intrapartum complications. Risk factors for GD can be identified in the first trimester from maternal history (age, obesity, previous macrosomia or GD, family history of diabetes), biochemical markers (adiponectin, sex hormone-binding globuline and others), and biophysical markers (arteriography, visceral adiposity). Risk factors for macrosomia include obesity and diabetes in the maternal history, pregnancy associated plasma protein-A and free b subunit of human chorionic gonadotropin as biochemical markers, and nuchal translucency and uterine artery Doppler as biophysical markers. Prediction models

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High macrosomia rate in healthy fetuses after enlarged nuchal translucency

Abstract: First trimester PAPP-A MoM and NT MoM are significantly related to birth weight centiles. Enlarged NT is associated with macrosomia.

Cited by 6 publications

References 45 publications

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Role of first trimester screening test in predicting the perinatal outcomes in low risk term pregnancies

Cribado precoz de diabetes gestacional y macrosomía

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