Does Non-Acetylated Salicylate Inhibit Thromboxane Biosynthesis in Human Platelets?

Danesh, B. J. Z.; McLaren, M.; Russell, Robin; Lowe, G. D. O.; Forbes, C.D.

doi:10.1177/003693308803300416

Cited by 8 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4 Importantly, therapeutic benefit is not compromised by using choline magnesium trisalicylate in lieu of aspirin. Studies in adult patients have shown that serum salicylate concentrations and salicylates elimination rates are equivalent to those reported for aspirin.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Moffett

Arora

Bricker

2003

The Journal of Pediatric Pharmacology and Therapeutics

View full text Add to dashboard Cite

Acute rheumatic fever is a post-infectious illness characterized by diffuse inflammation. Typically, high-dose anti-inflammatory agents are used as primary therapy for this disorder. In addition to their anti-inflammatory properties, these agents, most frequently aspirin, also have anti-platelet properties. We describe the case of an 11-year-old patient with rheumatic fever who needed to undergo surgery. The use of traditional anti-inflammatory agents would have posed a potential problem with postsurgical bleeding, so a lesser-used anti-inflammatory agent (i.e., choline magnesium trisalicylate) was selected.KEYWORDS: acute rheumatic carditis, anti-inflammatory, choline magnesium trisalicylate, pediatric, Trilisate 2003;8:284-6 An 11-year-old male with a history of Trisomy 21 and obesity presented to our hospital with complaints of shortness of breath and tachypnea. He had no known history of congenital heart disease. On review of systems, he had a 1-month history of arthralgias but did not have any history of fever or sore throat. In addition, he had a prolonged history of loud breathing during sleep and occasional apnea. His vital signs were notable for mild desaturation with a room air oxygen saturation of 88%. J Pediatr Pharmacol TherHis physical examination was remarkable for facies consistent with Trisomy 21, obesity, tonsillar hypertrophy, diminished breath sounds at his lung bases bilaterally, and quiet heart sounds with an intermittent III/VI holosystolic murmur heard best at the apex. There were no diastolic murmurs. His liver edge was palpable approximately 3-4 cm below the right costal margin. His chest radiograph showed an enlarged cardiac silhouette, bilateral pleural effusions, and increased pulmonary vascular markings. His laboratory studies were remarkable for an elevated erythrocyte sedimentation rate (ESR) of 106 mm/ hour (nl=0-20 mm/hour), an elevated C-reactive protein of 8.4 mg/dL (nl=0-1 mg/dL), and an elevated antistreptolysin (ASO) of 400 IU/mL (nl <250 IU/mL). An echocardiogram performed showed normal intracardiac anatomy with severe aortic regurgitation, moderate mitral regurgitation, no evidence of vegetations, a dilated left atrium and left ventricle, and good left ventricular function. His left ventricular shortening fraction was 41%, and he had qualitatively good right ventricular function.He met the criteria for acute rheumatic fever (major criteria = carditis, 2 minor criteria = elevated ESR and history of arthralgias, and evidence of recent streptococcal infection = elevated ASO).

show abstract

Section: Discussionmentioning

confidence: 99%

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Moffett

Arora

Bricker

2003

The Journal of Pediatric Pharmacology and Therapeutics

View full text Add to dashboard Cite

show abstract

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

Cryer¹,

Feldman

1992

Arch Intern Med

View full text Add to dashboard Cite

Although nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for pain relief and treatment of arthritis, they can induce gastric and duodenal ulcers and life-threatening complications. The mechanisms of their anti-inflammatory action and their gastroduodenal toxic effects are related, in part, to inhibition of prostaglandin synthesis. This review article discusses prostaglandins, their functions in the gastrointestinal tract, anti-inflammatory actions of NSAIDs, and mechanisms by which NSAIDs produce gastroduodenal ulcers. Also reviewed are risk factors associated with the development of NSAID-related ulcers and pharmacologic strategies for the prevention and treatment of NSAID-induced ulcers.

show abstract

Influence of Sucralfate on Trilisate Bioavailability

Schneider

Gannon

Sweeney

et al. 1991

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Twelve healthy human volunteers were randomized to receive either choline-magnesium trisalicylate (CMT) 1.5 g orally every 12 hours or a combination of CMT plus sucralfate 1 g orally every 6 hours for 5 days before the blood sampling day. After a 3-week washout period, the subjects were crossed over to receive the alternate treatment for 5 days. The mean (+/- SD) area under the curve was 2668 (729) mg - hr/L and 2748 (716) mg - hr/L for CMT and CMT/sucralfate treatments, respectively. Mean (+/- SD) maximum concentration was 275 (69) mg/L and 283 (75) mg/L for CMT and CMT/sucralfate administrations, respectively. Mean (+/- SD) time to maximum concentration for CMT and CMT/sucralfate treatments was 1.8 (0.6) hours and 1.7 (0.7) hours, respectively. There were no significant differences detected for any parameter, therefore sucralfate does not affect rate or extent of CMT absorption.

show abstract

Does Non-Acetylated Salicylate Inhibit Thromboxane Biosynthesis in Human Platelets?

Cited by 8 publications

References 5 publications

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Treatment of Acute Rheumatic Carditis with Choline Magnesium Trisalicylate in a Patient Needing Surgery

Effects of Nonsteroidal Anti-inflammatory Drugs on Endogenous Gastrointestinal Prostaglandins and Therapeutic Strategies for Prevention and Treatment of Nonsteroidal Anti-inflammatory Drug—Induced Damage

Influence of Sucralfate on Trilisate Bioavailability

Contact Info

Product

Resources

About