Does morphology of carotid plaque depend on patient's oxidative stress?

Różalski, Rafał; Migdalski, Arkadiusz; Gackowski, Daniel; Guz, Jolanta; Siomek, Agnieszka; Foksiński, Marek; Szpila, Anna; Zarakowska, Ewelina; Majer, Marcin; Jawień, Arkadiusz

doi:10.1016/j.clinbiochem.2013.05.057

Cited by 9 publications

(13 citation statements)

References 30 publications

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“…No effect of antioxidants on cIMT was previously reported either [16]. These data confirm the clinical importance of disturbances in oxidoreductive balance in the pathogenesis of atherosclerosis, and suggest that serum antioxidant level, especially vitamin E, may act as a biomarker for the risk of atherosclerosis [19,44].…”

Section: Discussionsupporting

confidence: 64%

“…Moreover, detailed examinations of oxidoreductive balance were performed as previously described [19][20][21][22]…”

Section: Resultsmentioning

confidence: 99%

“…We have found a non-significantly greater urine concentration of 8-oxoGua in patients with clinically silent signs of atherosclerosis ( Table 2). Różalski et al [19] found that patients, who qualified for carotid endarterectomy and had echolucent carotid plaques (gray-scale median score < 25), had also the highest antioxidant level and lowest excretion of DNA repair markers than remained patients and control. In a study by Sigala et al [25], a higher level of oxidative stress expressed by the presence of ox-LDL in blood was associated with the presence of symptoms of carotid atherosclerotic plaque instability.…”

Section: Discussionmentioning

confidence: 99%

“…8-oxo guanine (8-oxo-Gua) and 8-oxo-dG, as well as on blood determination of parameters of antioxidant defence, such as retinol (vitamin A), ascorbic acid (vitamin C), tocopherol (vitamin E), uric acid, glutathione, antioxidative enzymes, etc. [19][20][21][22][23][24][25]. The aim of this study, which was performed with adult patients without clinical manifestation of vascular diseases, was to compare the levels of these substances between individuals with and without signs of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

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Systemowa równowaga antyoksyacyjna u pacjentów bez klinicznej manifestacji miażdżycy

et al. 2018

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Introduction. Oxidative stress plays an important role in atherosclerosis, but numerous clinical trials have not confirmed a favourable effect of antioxidant supplementation. We aimed to determine the oxidative stress parameters in patients without clinical manifestation of vascular disease. Material and methods. Forty-eight patients were divided into two groups in relation to the presence or absence of clinically silent signs of atherosclerosis (ankle-brachial index < 0.9, intima-media thickness ≥ 0.9 mm, the presence of carotid atherosclerotic plaques, silent ischaemia in a treadmill stress test or focal myocardial contractility found in echocardiography). Plasma concentrations of: retinol, ascorbic acid, alpha-tocopherol and uric acid, as well as the products of oxidative DNA damage repair: 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in blood leucocytes and urine, and 8-oxo-7,8-dihydroguanine (8-oxo-Gua) in urine. Results. Patients with signs of subclinical atherosclerosis had lower blood concentration of alpha-tocopherol, and a non-significantly greater urine concentration of 8-oxoGua. Women had significantly greater blood concentration of ascorbic acid and alpha-tocopherol, as well as lower level of retinol and uric acid. They also had greater leucocyte concentration of 8-oxodG. Plasma concentration of alpha-tocopherol 30.34 μM distinguished patients with and without signs of subclinical atherosclerosis. Conclusions. Oxidative stress has clinical importance in the early stages of atherosclerosis and may be helpful in predicting its subclinical stage. Women had higher level of antioxidant defence, which explains their natural protection against early atherosclerosis development. Further studies are needed to determine the usefulness of tocopherol determination as a biomarker for atherosclerosis risk evaluation.

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Section: Discussionsupporting

confidence: 64%

“…Moreover, detailed examinations of oxidoreductive balance were performed as previously described [19][20][21][22]…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemowa równowaga antyoksyacyjna u pacjentów bez klinicznej manifestacji miażdżycy

et al. 2018

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“…Some studies suggest that high serum hs-CRP levels can predict the presence of carotid plaque, [14][15][16] although other studies could not establish that association 17,18 or any correlation with the degree of stenosis. 14,19 Plaque type relation to hs-CRP levels is also diverse: some studies report association with echolucent plaques, 20,21 but other studies correlated hs-CRP levels with increased plaque volume, but not with echolucency 17,22 or grey-scale median (GSM) value. 23 hs-CRP may predict plaque instability on MR imaging (hypointensity in T1 weighted images) 24 and levels 5 mg/L or greater were significantly associated with a greater number of new cerebral lesions detected on diffusionweighted MR imaging during carotid artery stenting, 25 but did not correlate with plaque inflammation as determined by carotid artery fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET).…”

Section: Biomarker Descriptionsmentioning

confidence: 99%

Review of serum biomarkers in carotid atherosclerosis

Martinez

Martorell

Riambau

2020

Journal of Vascular Surgery

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Background: Carotid artery atherosclerotic stenosis is a preventable major cause of stroke, but there is still a need for definition of high-risk plaque in asymptomatic patients who might benefit from interventional therapies. Several image markers are recommended to characterize unstable plaques. The measurement of serum biomarkers is a promising method to assist in decision making, but the lack of robust evidence in the carotid environment burdens their potential as a standard of care. The goal of this review was to offer an updated state-of-the-art study of available serum biomarkers with clinical implications, with focus on those that may predict carotid symptom development. Methods: The Cochrane Library and MEDLINE databases were searched (all until September 2018) for studies on carotid plaque and serum biomarkers of atherosclerosis. Nonhuman, basic science, and histology studies were excluded, focusing on clinical studies. Selected abstracts were screened to include the most relevant articles on atherosclerotic plaque presence, progression, instability or symptom development. Results: Some well-established biomarkers for coronary disease are not relevant to carotid atherosclerosis and other inflammatory biomarkers, lipids, interleukins, homocysteine, and adipokines may be useful in quantifying carotid disease-related risk. Some serum biomarkers combined with image features may assist vascular specialists in selecting patients at high risk for stroke and in need of intervention. Conclusions: Prospective studies applying a combination of biomarkers are essential to prove clinical usefulness.

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Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima–media thickness

Tan

Liu

et al. 2014

Atherosclerosis

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Does morphology of carotid plaque depend on patient's oxidative stress?

Cited by 9 publications

References 30 publications

Systemowa równowaga antyoksyacyjna u pacjentów bez klinicznej manifestacji miażdżycy

Systemowa równowaga antyoksyacyjna u pacjentów bez klinicznej manifestacji miażdżycy

Review of serum biomarkers in carotid atherosclerosis

Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima–media thickness

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