Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima–media thickness

Tan, Chong-Tin; Liu, Yi; Li, Weina; Deng, Fang; Liu, Xi; Wang, Xin; Gui, Yuejiang; Qin, Lu; Hu, Chung-Yi; Chen, Lifen

doi:10.1016/j.atherosclerosis.2013.11.040

Cited by 67 publications

(57 citation statements)

References 40 publications

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“…This result confirms the role MMP-9 and TIMP-1 play in CAAP destabilization and as predictive markers of CAAP phenotype. Similar results were obtained by other authors [5][6][7][8][13][14]. Furthermore, we found a significant positive correlation between serum levels of MMP-9/TIMP-1 and the degree of carotid stenosis, which is consistent with the findings of some other researchers [4,[14][15][16][17].…”

Section: Discussionsupporting

confidence: 82%

Relationship between the Levels of MMP-9, TIMP-1, and Zinc in Biological Samples of Patients with Carotid Atherosclerosis

Usmanova¹

2015

Int J Biomed

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The aim our study was to evaluate the levels of zinc in blood serum, hair, and specimens of carotid artery atherosclerotic plaques (CAAPs) and their relationship to levels of MMP-9 and TIMP-1 in the serum of patients with stable and unstable CAAPs.Material and Methods: The study included 73 patients (55 men and 18 women) aged from 46 to 88 years (mean age 65.96±1.07 years) with CAAPs. The control group consisted of 10 healthy subjects of similar age and gender. The patients were divided into two groups depending on their atherosclerotic plaque stability according to prior duplex ultrasonography. Group 1 consisted of 45 patients with stable atherosclerotic plaque, and Group 2 included 28 patients with unstable AP. Patients with hemodynamically significant carotid stenosis and unstable atherosclerotic plaques underwent carotid endarterectomy. The serum concentration of MMP-9 and TIMP-1 was determined using the standard test systems for immunoassay. Quantitative determination of the zinc level in hair and atherosclerotic plaque was carried out by optical emission spectrometry; the serum Zn was determined colorimetrically.Results: The serum levels of MMP-9 and TIMP-1 were significantly higher in Group 2 compared to Group1 and the control group. The index of MMP-9/TIMP-1 was 1.6 times higher in Group 2 compared to the control group. The level of Zn in serum and hair was not significantly different between Groups 1 and 2. However, Zn levels in unstable atherosclerotic plaque were lower than in the control group. Reducing the concentration of zinc in the hair was accompanied by a decrease in zinc level in atherosclerotic plaque specimens. With the progression of atherosclerosis and increasing the intima-media thickness of the common carotid artery, the level of zinc in serum and atherosclerotic plaques decreased. Increasing the serum concentration of MMP-9 was accompanied by decreasing the zinc level in atherosclerotic plaque. High serum concentration of MMP-9 and TIMP-1, and MMP-9/TIMP-1 imbalance testify to CAAP instability.Keywords: carotid atherosclerosis; atherosclerotic plaque; matrix metalloproteinase-9 (MMP-9); TIMP metallopeptidase inhibitor 1; zinc.

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Section: Discussionsupporting

confidence: 82%

Relationship between the Levels of MMP-9, TIMP-1, and Zinc in Biological Samples of Patients with Carotid Atherosclerosis

Usmanova¹

2015

Int J Biomed

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“…In both rheumatoid arthritis and osteoarthritis, MMP9 is elevated in the cartilage and synovial tissue, playing a significant role in the pathophysiology of these arthropathies (30). In atherosclerotic plaques, higher serum levels of MMP9 are associated with increased plaque instability (31). Additionally, patients with stable or unstable angina who had elevated systemic levels of MMP9 had higher Framingham cardiovascular risk score and increased risk of cardiovascular mortality (32).…”

Section: Discussionmentioning

confidence: 99%

Novel inflammatory biomarkers in primary hyperparathyroidism

Christensen

Fenne

Nordbø

et al. 2015

European Journal of Endocrinology

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Objective: Primary hyperparathyroidism (PHPT) has been associated with low-grade inflammation and increased risk of cardiovascular disease (CVD). The aim of the study was to investigate systemic levels of pro-inflammatory proteins that previously have not been examined in patients with PHPT. The selection of the pro-inflammatory biomarkers included in this study, MMP9, S100A4, S100A8/A9 and the receptors sCD14 and RAGE, was based on a previous microarray screen of mRNAs in adipose tissue from PHPT patients. Design: A prospective study was conducted on a total of 57 patients with PHPT and a control group of 20 healthy blood donors. Methods: PHPT patients with normalisation of serum calcium levels after parathyroidectomy were followed for 6 months. Forty-two patients participated in the longitudinal study, in which blood samples were taken at inclusion, and 1, 3 and 6 months after surgery. Results: We observed increased serum levels of MMP9 (PZ0.029), S100A4 (P!0.001) and sCD14 (PZ0.002) in the 57 patients with PHPT compared to the control-group. During 6 months of follow up, S100A4 (PZ0.022) and sCD14 (0.002) decreased significantly, while serum levels of MMP9 increased (PZ0.025). Conclusions:The results demonstrate an increased inflammatory response in PHPT patients shown by elevated MMP9, S100A4 and sCD14 at inclusion. During the 6 months of follow-up, MMP9 increased further, possibly due to the tissue repair process after parathyroidectomy. S100A4 and sCD14 decreased after surgery demonstrating a partial reversal of the systemic inflammation.

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“…Like IL8, MCP-1 is a chemokine that has been implicated in a variety of inflammatory diseases, including atherosclerosis [35,36]. A subanalysis in the MONICA/KORA study has also shown that the G allele of SNP rs12075 is associated with reduction (by 7%) in the serum levels of IL8 [2].…”

Section: Discussionmentioning

confidence: 94%

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

et al. 2015

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Associations of matrix metalloproteinase-9 and monocyte chemoattractant protein-1 concentrations with carotid atherosclerosis, based on measurements of plaque and intima–media thickness

Cited by 67 publications

References 40 publications

Relationship between the Levels of MMP-9, TIMP-1, and Zinc in Biological Samples of Patients with Carotid Atherosclerosis

Relationship between the Levels of MMP-9, TIMP-1, and Zinc in Biological Samples of Patients with Carotid Atherosclerosis

Novel inflammatory biomarkers in primary hyperparathyroidism

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

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