Does miR-197 Represent a Valid Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma (HNSCC)? A Systematic Review and Trial Sequential Analysis

Dioguardi, Mario; Cantore, Stefania; Sovereto, Diego; Femina, Lucia La; Spirito, Francesca; Caloro, Giorgia Apollonia; Caroprese, Marino; Maci, Marta; Scacco, Salvatore; Muzio, Lorenzo Lo; Cosola, Michele Di; Troiano, Giuseppe; Ballini, Andrea

doi:10.3390/jpm12091436

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…In light of the data reported in the medical literature, and from the preliminary research conducted in the field [6][7][8][9]13,14,119], we carried out our review after registering it on Prospero, which was written following the indications of PRISMA. A meta-analysis of the data was not carried out due to the excessive heterogeneity of data and histological subtypes of HNSCCs, and thus a TCGA analysis was instead used to test possible microRNA biosignatures that emerged from the data extraction and qualitative analysis of the studies.…”

Section: Discussionmentioning

confidence: 99%

“…The systematic reviews included were the following: Dioguardi et al, 2023 [9]; Dioguardi et al, 2022 [13]; Dioguardi et al, 2022 [14]; Dioguardi et al, 2022 [8]; Dioguardi et. al, 2022 [6]; Dioguardi et al, 2022 [7]; Irimie-Aghiorghiese et al, 2019 [15]; Lubov et al, 2017 [16]; Xie and Wu, 2017 [17]; Wang et al, 2019 [18]; Li et al, 2019 [19]; Qiu et al, 2021 [20]; Huang et al, 2021 [21]; Jamali et al, 2015 [22]; and Troiano et al, 2018 [23].…”

Section: Data Characteristics: Systematic Reviewmentioning

confidence: 99%

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The Potential microRNA Prognostic Signature in HNSCCs: A Systematic Review

Dioguardi,

Spirito,

Iacovelli

et al. 2023

ncRNA

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Head and neck squamous cell carcinomas (HNSCCs) are often diagnosed at advanced stages, incurring significant high mortality and morbidity. Several microRNAs (miRs) have been identified as pivotal players in the onset and advancement of HNSCCs, operating as either oncogenes or tumor suppressors. Distinctive miR patterns identified in tumor samples, as well as in serum, plasma, or saliva, from patients have significant clinical potential for use in the diagnosis and prognosis of HNSCCs and as potential therapeutic targets. The aim of this study was to identify previous systematic reviews with meta-analysis data and clinical trials that showed the most promising miRs in HNSCCs, enclosing them into a biomolecular signature to test the prognostic value on a cohort of HNSCC patients according to The Cancer Genome Atlas (TCGA). Three electronic databases (PubMed, Scopus, and Science Direct) and one registry (the Cochrane Library) were investigated, and a combination of keywords such as “signature microRNA OR miR” AND “HNSCC OR LSCC OR OSCC OR oral cancer” were searched. In total, 15 systematic literature reviews and 76 prognostic clinical reports were identified for the study design and inclusion process. All survival index data were extracted, and the three miRs (miR-21, miR-155, and miR-375) most investigated and presenting the largest number of patients included in the studies were selected in a molecular biosignature. The difference between high and low tissue expression levels of miR-21, miR-155, and miR-375 for OS had an HR = 1.28, with 95% CI: [0.95, 1.72]. In conclusion, the current evidence suggests that miRNAs have potential prognostic value to serve as screening tools for clinical practice in HNSCC follow-up and treatment. Further large-scale cohort studies focusing on these miRNAs are recommended to verify the clinical utility of these markers individually and/or in combination.

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Section: Discussionmentioning

confidence: 99%

Section: Data Characteristics: Systematic Reviewmentioning

confidence: 99%

The Potential microRNA Prognostic Signature in HNSCCs: A Systematic Review

Dioguardi,

Spirito,

Iacovelli

et al. 2023

ncRNA

Self Cite

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“…The planning of this systematic review and meta-analysis was performed according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, and following the indications of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) [ 18 , 19 , 20 , 24 , 25 , 26 , 27 ] The review protocol was previously registered on INPLASY (International Platform of Registered Systematic Review and Meta-analysis Protocols) with registration number INPLASY202240150 and the DOI is 10.37766/inplasy2022.4.0150.…”

Section: Methodsmentioning

confidence: 99%

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Dioguardi

Spirito

Caloro

et al. 2023

JPM

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Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of neoplasms whose histological derivation comes from the mucous membranes lining the epithelium: the oral cavity, the larynx, the hypopharynx, the nasopharynx, and the oropharynx. The etiopathogenetic mechanisms involving tumor genesis including the alteration of cell proliferation, apoptosis, invasion, migration, and death may involve alterations in the expression of microRNA (miR). To date there have been no systematic reviews with meta-analysis conducted specifically on the role of miR-195 in HNSCC; therefore, our hypothesis was to evaluate if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through the hazard ratio (HR) and relative risk (RR) analysis. The systematic review was designed according to the PRISMA indications; in total, three electronic databases were consulted (PubMed, Scopus, Cochrane Central Trial) including Google Scholar and the gray literature, and a combination of keywords was used such as miR-195 AND HNSCC, microRNA AND HNSCC and miR-195. The meta-analysis and trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles and, at the end of the selection process, three articles were included. The results of the meta-analysis reported an aggregated risk ratio for overall survival (OS) between the expression of miR-195 at the highest and lowest of 0.36 and 6, respectively, 95% CI: [0.25, 0.51]. Heterogeneity was evaluated through Chi2 = 0.05 df = 2 (p = 0.98) and the Higgins index I2 = 0%. The test for the overall effect was Z = 5.77 (p < 0.00001). The forest plot was in favor of higher OS in patients with high miR-195 expression.

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“…MicroRNAs (miRNAs) are a class of small, single-stranded non-coding RNAs that plays a crucial role in post-transcriptional control: it is estimated that they regulate the expression of at least 30% of mammalian genes 145 . Through binding to target mRNAs, miRNAs can downregulate gene expression, effectively regulating several cellular processes, including cell differentiation, growth, proliferation, and apoptosis; alterations in miRNA expression are considered critical in cancer initiation and development 146 .…”

Section: The Overall Polyphenols Anticancer Activities In Hncmentioning

confidence: 99%

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

Ballini,

Zhurakivska,

Troiano

et al. 2024

J. Cancer

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Head and neck cancers (HNC) are a worldwide health problem, accounting for over 5% of all types of cancers. Their varied nature makes it sometimes difficult to find clear explanations for the molecular mechanisms that underline their onset and development. While chemio- and radiotherapy are clearly not to be dismissed, we cannot undervalue the effect that polyphenols - especially dietary polyphenols - can have in helping us to cope with this medical emergency. By influencing several different proteins involved in numerous different metabolic pathways, polyphenols can have a broad spectrum of biological action and can hopefully act synergistically to tackle down head and neck cancer. Moreover, being natural molecules, polyphenols does not present any side effects and can even enhance drugs efficacy, making our clinical therapy against head and neck cancer more and more effective. Certainly, oxidative stress plays an important role, altering several molecular pathways, lowering the body's defenses, and ultimately helping to create a microenvironment conducive to the appearance and development of the tumor. In this regard, the regular and constant intake of foods rich in polyphenols can help counteract the onset of oxidative stress, improving the health of the general population. In this review, we highlight the role of polyphenols in managing oxidative stress, with such positive effects that they can be considered new tools to use in our anti-head and neck cancer strategy.

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Does miR-197 Represent a Valid Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma (HNSCC)? A Systematic Review and Trial Sequential Analysis

Cited by 9 publications

References 52 publications

The Potential microRNA Prognostic Signature in HNSCCs: A Systematic Review

The Potential microRNA Prognostic Signature in HNSCCs: A Systematic Review

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Dietary Polyphenols against Oxidative Stress in Head and Neck Cancer: What's New, What's Next

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