Does mean platelet volume/lymphocyte count ratio associate with frailty in type 2 diabetes mellitus?

Abstract

OBJECTIVES: Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with infl ammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as infl ammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non-frail diabetic subjects. METHODS: Diabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale. General characteristics and laboratory data of the frail and non-frail groups were compared. RESULTS: The MPVLR of the frail (3.9 [1.4-13.2] %) group was signifi cantly higher than that of the non-frail (3.4 [1.5-6.9] %) group (p = 0.02). MPVLR was positively and signifi cantly correlated with Edmonton Frail Scale score (r = 0.21, p = 0.03). A MPVLR level greater than 3.41 % has 71 % sensitivity and 51 % specifi ty in predicting frailty. CONCLUSION: We suggest that elevated MPVLR could be a fi nding that marks frailty in diabetic subjects. Inexpensive and easy-to-assess nature of the MPVLR may be useful in predicting frailty in type 2 diabetic population (Tab. 2, Fig. 1, Ref. 32).

Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review

“…The mean platelet volume and lymphocyte count, contributors to the mean platelet-volume-to-lymphocyte ratio (MPVLR), are also associated with inflammatory conditions. The role of this new inflammatory marker in frailty has also been studied by Bilgin et al [ 30 ], who found that a higher MPVLR was associated with the condition of being frail and its severity in subjects with type 2 diabetes. Furthermore, an MPVLR value above 3.41% predicted frailty with high sensitivity (71%) and moderate specificity (51%).…”

“…Likewise, using the deficit accumulation index, several studies quantified frailty syndrome by means of shorter items’ scales such as the Carolina Frailty Index (CFI) based on 36 items [ 21 ], an 11-item modified Frailty Index (mFI), and the Frailty index containing 36 possible “health deficits”. Finally, a study applied the Edmonton Frailty Scale (EFS) to assess frailty [ 30 ]. This scale, an abbreviated assessment of the Comprehensive Geriatric Assessment, takes into account 10 domains (cognition, mood, functional independence, medication use, social support, nutrition, health attitudes, continence, burden of medical illness, and quality of life); its maximum score is 17 and represents the highest level of frailty [ 31 ].…”

“…The association between frailty syndrome and B cell counts was only reported in two studies, with the Rockwood frailty scale in one study [ 12 ] and Fried’s scale in another one [ 17 ]. In a subcohort study performed in older adults belonging to the Doetinchem cohort study in the Netherlands, the frailty syndrome was associated with some lymphocyte subpopulations among the 37 subpopulations studied [ 30 ]. Frailer women, but not men, showed fewer T lymphocytes, and CD56+ T cells in particular [ 30 ], which are known for their cytotoxic capacity [ 22 ].…”

“…In a subcohort study performed in older adults belonging to the Doetinchem cohort study in the Netherlands, the frailty syndrome was associated with some lymphocyte subpopulations among the 37 subpopulations studied [ 30 ]. Frailer women, but not men, showed fewer T lymphocytes, and CD56+ T cells in particular [ 30 ], which are known for their cytotoxic capacity [ 22 ]. This result is consistent with another study reporting an increased expression of CD56 in lymphocyte T cells from individuals with better cognitive and physical functioning [ 47 ].…”

The Diagnostic Value of Synovial Fluid Lymphocytes in Gout Patients

“…McCabe et al found that total synovial fluid leukocytes appeared to be a biomarker for MRI synovitis and may also predict response to treatment in OA patients [12]. Lymphocyte or lymphocytederived indices are somehow involved in the processes of many inflammatory conditions, including COVID-19, irritable bowel syndrome, thyroiditis, and frailty [13][14][15][16]. The diagnostic value of synovial fluid peripheral blood mononuclear cells (PBMCs), eosinophils, neutrophils, lymphocytes, and monocytes in gout patients compared with RA, axSpA, and OA patients has not yet been described.…”