Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review

Navarro-Martínez, Rut; Cauli, Omar

doi:10.3390/diseases9030053

Cited by 5 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Penurunan jumlah limfosit total dalam darah diyakini menjadi penanda khas terjadinya perubahan yang merusak pada sistem imunitas yang berkaitan dengan penuaan. 26 Penurunan jumlah limfosit atau limfositopenia dianggap sebagai indikator penurunan umum fungsi fisiologis, dan merupakan faktor dari prognosis buruk pada pasien rawat inap. Hasil pada penelitian ini sejalan dengan riset Antonio yaitu jumlah limfosit yang rendah berkorelasi dengan rawat inap yang lebih lama.…”

Section: Metode Penelitianunclassified

Hubungan Kadar Albumin, Limfosit, dan Komorbiditas dengan Lama Rawat Inap

Istiqomah

Cahyawati²,

Panghiyangani

2022

View full text Add to dashboard Cite

Hypoalbuminemia is common in the elderly patients. Along with aging there is a decrease in physiological functions including the immune system which causes lymphopenia. Comorbidities also increase significantly with age. This research is analytic observational with cross-sectional method aimed to analyze the correlation of albumin, lymphocytes, and comorbidities with the length of stay of elderly patients. The research sample of 31 elderly people was obtained using a total sampling technique according to the inclusion and exclusion criteria. The mean albumin level was 3.07±0.61 gr/dl. The mean lymphocyte value was 17.84±9.68 %. The median comorbidity score was 2 with a minimum was 0 and the maximum was 4. The average length of stay for elderly patients was 7±3.84 days. There is a significant correlation between lymphocytes and LOS in elderly patients (r=-0,45;p=0,011). There is a significant correlation between comorbidities and LOS in elderly patients (r=0,368;p=0,042). There is no correlation between albumin and LOS of elderly patients (p>0.05) in the Internal Medicine Ward at Ulin Hospital Banjarmasin. Keywords: albumin levels, lymphocyte, comorbidity, length of stay, elderly Abstrak: Hipoalbuminemia umum ditemukan pada lansia. Seiring dengan peningkatan usia terjadi penurunan fungsi fisiologis termasuk pada sistem imunitas yang pada akhirnya menyebabkan limfopenia. Komorbiditas pun meningkat secara signifikan seiring bertambahnya usia. Penelitian ini bersifat observasional analitik dengan metode cross-sectional dan bertujuan untuk menganalisis korelasi albumin, limfosit, dan komorbiditas dengan lama rawat inap pasien lansia. Sampel penelitian sejumlah 31 lansia diperoleh menggunakan teknik total sampling sesuai kriteria inklusi dan eksklusi. Rerata kadar albumin 3,07 gr/dl±0,61. Rerata nilai limfosit 17,84%±9,68. Median skor komorbiditas didapatkan skor 2 dengan minimal 0 dan maksimal 4. Rerata lama rawat inap pasien lansia adalah 7±3,84 hari. Terdapat korelasi signifikan antara limfosit dan lama rawat pasien lansia (r=-0,45; p=0,011). Terdapat korelasi signifikan antara komorbiditas dan lama rawat pasien lansia (r=0,368; p=0,042). Tidak terdapat korelasi antara albumin dengan lama rawat pasien lansia (p>0,05) di Ruang Rawat Penyakit Dalam RSUD Ulin Banjarmasin. Kata-kata kunci: kadar albumin, limfosit, komorbiditas, lama rawat inap, lansia

show abstract

Section: Metode Penelitianunclassified

Hubungan Kadar Albumin, Limfosit, dan Komorbiditas dengan Lama Rawat Inap

Istiqomah

Cahyawati²,

Panghiyangani

2022

View full text Add to dashboard Cite

show abstract

Neutrophil-to-Lymphocyte Ratio Amplifies the Effects of Aging on Decrements in Grip Strength and Its Functional Neural Underpinnings

Dillon

Goodman

Kaur

et al. 2023

The Journals of Gerontology: Series A

View full text Add to dashboard Cite

The neutrophil to lymphocyte ratio (NLR) is a trans-prognostic biomarker of physiologic stress and inflammation linked to muscle weakness in older adults. Generation of grip force coincides with sustained activity in the primary sensorimotor cortex (SM1). The current study investigates whether whole-brain functional connectivity, i.e., degree centrality (CD) of SM1 relates to grip strength and whether both functional measures are predicted by advancing age as a function of the NLR. A structural regression model investigated main and interactive effects of age and NLR on grip strength and CD of SM1 in 589 adults aged 21-85 years (M = 45.87, SD = 18.06). The model including the entire sample had good fit (χ2(4) = 1.63, p = .804). In individuals aged 50 years and older, age predicted lower grip strength and SM1 CD as a function of increasing NLR. In a model stratified by sex, the effect of age, NLR, and their interaction on grip strength are significant for older men but not older women. Analyses support CD of SM1 at rest as a neural biomarker of grip strength. Grip and its neural underpinnings decrease with advancing age and increasing NLR in mid- to late-life. Age-related decrements in grip strength and functional connectivity of brain regions involved in the generation of dynamic grip appear to be accelerated as a function of systemic physiological stress and inflammation, particularly in older men.

show abstract

‘Frailty and prognosis in lung cancer: systematic review and meta-analysis’

Liu,

Peng,

Geng

et al. 2023

BMJ Support Palliat Care

View full text Add to dashboard Cite

Lung cancer is one of the most common malignant tumours. Patients are frequently at risk of frailty as lung cancer progresses. The meta-analysis aims to explore the impact of frailty on the long-term prognosis and the incidence of short-term chemotherapy toxicity in patients with lung cancer. This study was designed adhered to the criteria of Cochrane Handbook for Systematic Reviews. Systematic searches were performed on PubMed, Embase, Web of Science and Cochrane Library databases for relevant studies until December 2022. The outcome measures were overall survival, progression-free survival, chemotherapy toxicity and all-cause mortality. We then performed sensitivity analyses, subgroup analyses and evidence quality. This meta-analysis was performed using Review Manager V.5.4 software. Of the included studies, six were retrospective and five were prospective. There was a statistically significant difference between the frail and non-frail groups in overall survival (HR 2.27, 95% CI 1.24 to 4.15, p=0.008), all-cause mortality (HR 1.63, 95% CI 1.00 to 2.65, p=0.05) and chemotherapy toxicity (OR 3.73, 95% CI 1.99 to 7.00, p<0.0001). We conducted a sensitivity analysis, and the result was stable. The study revealed frail group had shorter survival and experienced more severe adverse effects than the non-frail group. Frailty affects the long-term prognosis and the incidence of short-term chemotherapy toxicity of patients with lung cancer. Consequently, medical professionals should focus on frailty screening in patients with lung cancer and implement active intervention measures. PROSPERO registration number is CRD42023398606.

show abstract

Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review

Cited by 5 publications

References 67 publications

Hubungan Kadar Albumin, Limfosit, dan Komorbiditas dengan Lama Rawat Inap

Hubungan Kadar Albumin, Limfosit, dan Komorbiditas dengan Lama Rawat Inap

Neutrophil-to-Lymphocyte Ratio Amplifies the Effects of Aging on Decrements in Grip Strength and Its Functional Neural Underpinnings

‘Frailty and prognosis in lung cancer: systematic review and meta-analysis’

Contact Info

Product

Resources

About