Does long-term coffee intake reduce type 2 diabetes mellitus risk?

Abstract

This review reports the evidence for a relation between long-term coffee intake and risk of type 2 diabetes mellitus. Numerous epidemiological studies have evaluated this association and, at this moment, at least fourteen out of eighteen cohort studies revealed a substantially lower risk of type 2 diabetes mellitus with frequent coffee intake. Moderate coffee intake (≥4 cups of coffee/d of 150 mL or ≥400 mg of caffeine/d) has generally been associated with a decrease in the risk of type 2 diabetes mellitus. Besides, results of most studies suggest a dose-response relation, with greater reductions in type 2 diabetes mellitus risk with higher levels of coffee consumption. Several mechanisms underlying this protective effect, as well as the coffee components responsible for this association are suggested. Despite positive findings, it is still premature to recommend an increase in coffee consumption as a public health strategy to prevent type 2 diabetes mellitus. More population-based surveys are necessary to clarify the long-term effects of decaffeinated and caffeinated coffee intake on the risk of type 2 diabetes mellitus.

Relationship Between Coffee Consumption and Prevalence of Metabolic Syndrome Among Japanese Civil Servants

“…24 , 25 In Japan, a prospective study reported that consuming 3 or more cups of coffee per day was inversely associated with DM as compared with a reference group (0–1 cups of coffee per day). 26 In the present study, FPG and moderate coffee consumption (≥4 cups/day) were not correlated among men and women.…”

Metabolic Disorders

“…Coffee consumption, which is high in some Mediterranean countries, is associated with a reduced risk of type 2 diabetes [77,83]. Chlorogenic acid has a wide range of effects on glucose metabolism, and the high chlorogenic acid content of coffee may contribute to the association between coffee drinking and a reduced risk of type 2 diabetes [83].…”

“…Chlorogenic acid has a wide range of effects on glucose metabolism, and the high chlorogenic acid content of coffee may contribute to the association between coffee drinking and a reduced risk of type 2 diabetes [83]. Coffee is also a good source of magnesium, another substance that is associated with glucose homeostasis.…”

Kaffee und Diabetes

“…Dies ergab eine Analyse der Hoorn-Studie, bei der über 17.000 gesunde Personen über viele Jahre prospektiv verfolgt wurden: Bei Personen, die mehr als 7 Tassen Kaffee pro Tag tranken, war das Risiko an Typ-2-Diabetes zu erkranken, halbiert [22]. Darüberhinaus konnte gezeigt werden, dass eine inverse Beziehung zwischen der Höhe des Kaffeekonsums und dem Risiko für Typ-2-Diabetes besteht [23,24]. Rasch folgten weitere Studien aus Schweden [25,26], Finnland [27][28][29], Griechenland [30], Japan [31,32] und den USA [33,34], die zum gleichen Ergebnis kamen: Mit steigendem Kaffeekonsum reduziert sich das Risiko für die Entwicklung eines Typ-2-Diabetes.…”