Does ketoprofen or diclofenac pose the lowest risk to fish?

Cuklev, Filip; Fick, Jerker; Cvijović, Marija; Kristiansson, Erik; Förlin, Lars; Larsson, D. G. Joakim

doi:10.1016/j.jhazmat.2012.05.077

Cited by 39 publications

(29 citation statements)

References 47 publications

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“…No adverse effects were reported in any of these studies. Interestingly, when comparing the risks of ketoprofen and diclofenac in rainbow trout, ketoprofen was determined to be the safer of the two drugs, as diclofenac alters organ histology and gene expression in fish at 1 μg/L ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)

et al. 2020

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The objective of this study was to document the pharmacokinetics of ketoprofen following 3 mg/kg intramuscular (IM) and intravenous (IV) injections in rainbow trout ( Oncorhynchus mykiss ) and 8 mg/kg intramuscular (IM) injection in Nile tilapia ( Oreochromis niloticus) . Plasma was collected laterally from the tail vein for drug analysis at various time intervals up to 72 h following the injection of ketoprofen. In trout, area under the curve (AUC) levels were 115.24 μg hr/mL for IM and 135.69 μg hr/mL for IV groups with a half-life of 4.40 and 3.91 h, respectively. In both trout and tilapia, there were detectable ketoprofen concentrations in most fish for 24 h post-injection. In tilapia, there was a large difference between the R- and S-enantiomers, suggesting either chiral inversion from R- to S-enantiomer or more rapid clearance of the R-enantiomer. AUC values of the S- and R-enantiomers were 510 and 194 μg hr/Ml, respectively, corresponding to a faster clearance for the R-enantiomer. This study shows that there were very high plasma concentrations of ketoprofen in trout and tilapia with no adverse effects observed. Future studies on the efficacy, frequency of dosing, analgesia, adverse effects, and route of administration are warranted.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)

et al. 2020

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“…Other studies have reported cytological and histological effects Triebskorn et al, 2004;Hoeger et al, 2005;Mehinto et al, 2010) and gene expression changes after diclofenac exposure on fish (Cuklev et al, 2012).…”

Section: Introductionmentioning

confidence: 96%

Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish

Guiloski

Ribas

Pereira

et al. 2015

Ecotoxicology and Environmental Safety

110

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“…Moreover, the adsorbent exhibited high efficiency in the removal of another NSAID, i.e., Ketoprofen (Kp), from water with a potential application in the removal of the mixture Kp and DCF. Kp is also frequently found in surface waters, which constitutes a potential risk for aquatic ecosystems [21,22,23,24]. Besides the studies reported in literature about its removal [25,26,27,28,29,30], the proposed use of CH to treat water from the Kp, according to our knowledge, has been not yet investigated.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Film as Eco-Friendly and Recyclable Bio-Adsorbent to Remove/Recover Diclofenac, Ketoprofen, and Their Mixture from Wastewater

et al. 2019

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This paper reported the first example on the use of chitosan films, without further modification, to remove and recover, through bio-sorption processes, the emerging pollutant Diclofenac from water. The latter was adopted as a model, among non-steroidal anti-inflammatory drugs, by obtaining a maximum adsorption capacity, qmax, on chitosan of about 10 mg/g, under the applied experimental conditions of work. The literature gap about the use of chitosan films, which was already used for dyes and heavy metals removal, to adsorb emerging pollutants from water was covered, claiming the wide range application of chitosan films to remove a different class of pollutants. Several parameters affecting the Diclofenac adsorption process, such as the pH and ionic strength of solutions containing Diclofenac, the amount of the bio-sorbent and pollutant, and the temperature values, were investigated. The kinetics and the adsorption isotherms, along with the thermodynamic parameters (ΔG°, ΔH°, and ΔS°) were also evaluated. The process occurred very efficiently, and Chitosan/Diclofenac amounts dependent, remove about the 90% of the pollutant, in 2 h, from the tested solutions, through electrostatic interaction involving the carboxylic moiety of Diclofenac and Chitosan amino groups. This finding was confirmed by the pH and salt effects on the bio-sorption process, including swelling measurements of Chitosan films and by FTIR-ATR analysis. In detail, the maximum adsorption was observed at pH 5, when pollutant and Chitosan were negatively and positively charged, respectively. By reducing or increasing the pH around this value, a reduced affinity was observed. Accordingly, the presence of salts retarded the Diclofenac removal screening its charges, which hinders the interaction with Chitosan. The sorption was spontaneous (ΔG° < 0) and endothermic (ΔH° > 0) following the pseudo-second order kinetic model. The process was Diclofenac and Chitosan amount dependent. In addition, the Freundlich and Temkin isotherms well described the process, which showed the heterogeneous character of the process. Experiments of the complete desorption were also performed by using NaCl solutions 0.25 M (like sea water salt concentration) proposing the reuse of the pollutant and the recycling of the bio-sorbent lowering the associated costs. The versatility of the adsorbent was reported by exploring the possibility to induce the Diclofenac light-induced degradation after the adsorption and by-products adsorption onto chitosan films. To emphasize the chitosan capacity of treating water, the removal of another pollutant such as Ketoprofen and the mixture of Diclofenac and Ketoprofen were investigated. In this way, a green and eco-friendly production-pollution prevention technology for removing emerging pollutants from water was presented, which reduced the overall environmental impact. This illustrated experiments both in static and dynamic conditions for potential industrial applications.

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Does ketoprofen or diclofenac pose the lowest risk to fish?

Cited by 39 publications

References 47 publications

Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)

Pharmacokinetics of Ketoprofen in Nile Tilapia (Oreochromis niloticus) and Rainbow Trout (Oncorhynchus mykiss)

Effects of trophic exposure to dexamethasone and diclofenac in freshwater fish

Chitosan Film as Eco-Friendly and Recyclable Bio-Adsorbent to Remove/Recover Diclofenac, Ketoprofen, and Their Mixture from Wastewater

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