Does ibuprofen increase perioperative blood loss during hip arthroplasty?

Safety and efficacy of plasma‐derived coagulation factor IX concentrate (AlphaNine® SD) in patients with haemophilia B undergoing surgical intervention: a single institution retrospective analysis

“…Many cases, 15 of the 29 procedures, had blood loss less than 100 mL, and had no bleeding related complications or other adverse events. One patient who underwent a total hip arthroplasty had a 900 mL of blood loss that is e200 D. V. K QUON and L. LOGAN typical for a hip procedure [20][21][22][23][24]. Blood loss observed in the postsurgical drains was similar to the blood loss in surgeries performed in non-haemophilia patients [13].…”

Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial

“…The issue is whether the advantages of the COX-2 drug are important for (short) postoperative pain treatment. NSAIDs have been implicated in postoperative bleeding due to platelet aggregation inhibition [19][20][21]. COX-2 inhibitors lack such effect on platelet function; also, they do not affect blood coagulation parameters in patients receiving low molecular weight heparins for postoperative prophylaxis for deep vein thrombosis [8][9][10]22].…”

Effect of Drain Placed in the Donor Site in the Early Postoperative Period after Arthroscopically Assisted Anterior Cruciate Ligament Reconstruction with Quadrupled Hamstring Tendons

“…Ibuprofen is known to increase perioperative blood loss. 19 Because we did not have the analgesic consumption data, some patients in either group could have used less or more than the recommended dosage, and this occurance may have affected bleeding either way.…”