Does Hyperandrogenism Affect the Otoacoustic Emissions and Medial Olivocochlear Reflex in Female Adults?

Eren, Erdem; Harman, Ece; Arslanoğlu, Seçil; Önal, Kazım; Katlmiş, Hüseyin

doi:10.1097/mao.0b013e31828dae3e

Cited by 4 publications

(6 citation statements)

References 31 publications

(23 reference statements)

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“…Guinan 14 commented that the most important difficulty with using DPOAEs is that the effect can be in either direction and could change greatly with small changes in stimulus parameters, thereby making a single measurement difficult to interpret. As stated, activation of the MOC system can result in either enhancement of OAEs or suppression of OAEs 26 . In our study group, activation of the MOC reflex with DPOAEs revealed suppression and enhancement.…”

Section: Discussionsupporting

confidence: 70%

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Effects of Type 2 Diabetes on Otoacoustic Emissions and the Medial Olivocochlear Reflex

Eren

Harman

Arslanoğlu

et al. 2014

Otolaryngol.--head neck surg.

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Section: Discussionsupporting

confidence: 70%

“…As stated, activation of the MOC system can result in either enhancement of OAEs or suppression of OAEs. 26 In our study group, activation of the MOC reflex with DPOAEs revealed suppression and enhancement. We did not detect any compromise in MOC activity (in DPOAEs).…”

Section: Discussionmentioning

confidence: 46%

Effects of Type 2 Diabetes on Otoacoustic Emissions and the Medial Olivocochlear Reflex

Eren

Harman

Arslanoğlu

et al. 2014

Otolaryngol.--head neck surg.

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“…Although there is a lack of direct clinical evidence of testosterone and hearing loss, some studies considered that testosterone might have a negative impact on hearing because higher testosterone could lower the OAE amplitudes [ 66 ]. However, hyperandrogenism did not affect OAE or the medial olivocochlear reflex response in adult females [ 133 ]. As a result, whether androgen plays an essential role in ASNHL is still unclear.…”

Section: How Could Hormones Influence Hearing In Molecular Aspects?mentioning

confidence: 99%

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Lien

Yang

2021

IJMS

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The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.

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“…And hyperandrogenism may be responsible for the elevation of hearing threshold, particularly in the high frequency, in patients with polycystic ovary syndrome [30][31][32]. On the contrary, hyperandrogenism did not seem to affect otoacoustic emission levels or the medial olivocochlear reflex response in adult female subjects [33].…”

Section: Androgenmentioning

confidence: 88%

Sex Hormones and Inner Ear

He¹

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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There are increasing evidence of interactions between sex hormones and the structure and function of inner ear, especially in hearing impairment and balance disorders. In this chapter, we will discuss the mechanism of sex hormones on the inner ear, describe both clinical and basic research that has led us to our current understanding, and conclude with future perspectives on avenues of investigation that may lead to innovative treatments on the hearing loss, tinnitus, and dizziness resulted from the changes in estrogen and progesterone levels. The presence of estrogen receptors α and β has earlier been shown in the inner ear of mice. Expression of estrogen receptors (ER) correlates with the protection of auditory function. Estrogen may have certain protective effects on the hearing. Evidence for the treatment of sex hormone-induced symptoms is principally restricted to case reports and retrospective studies. Recognition and understanding of sex hormone-related inner ear problems will allow otologists to notice and manage these patients. Also, basic studies on the mechanism of how sex hormones act on inner ear provide the way to further prevent and treat on hearing impairment and balance disorders. High-quality evidence for their management is limited, with further research required.

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Does Hyperandrogenism Affect the Otoacoustic Emissions and Medial Olivocochlear Reflex in Female Adults?

Abstract: Hyperandrogenism did not seem to influence otoacoustic emission levels or the medial olivocochlear reflex response in adult female subjects.

Cited by 4 publications

References 31 publications

Effects of Type 2 Diabetes on Otoacoustic Emissions and the Medial Olivocochlear Reflex

Effects of Type 2 Diabetes on Otoacoustic Emissions and the Medial Olivocochlear Reflex

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Sex Hormones and Inner Ear

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