Does Hormonal Skin Aging Exist? A Study of the Influence of Different Hormone Therapy Regimens on the Skin of Postmenopausal Women Using Non-Invasive Measurement Techniques

Callens, Anne-Céline; Vaillant, L.; Lecomte, P.; Berson, M.; Gall, Y.; Lorette, G

doi:10.1159/000246272

Cited by 169 publications

(86 citation statements)

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“…Hormone replacement therapy has been correlated with enhancement of collagen production, increase in skin thickness, surface lipids, hydration, vascularisation and increase of the hair follicle life cycle (Brincat, 2000;Callens et al, 1996;Fuchs et al, 2003;Patriarca et al, 2007;Sator et al, 2007;Sator et al, 2001) leading to an improvement of skin tone and appearance. Hormone replacement may only improve the skin quality in female patients treated during the first 24 months after menopause (Phillips et al, 2008) (Table I).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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“…En relación con el envejecimiento microscópi-co, Callens et al 20 trataron a 98 mujeres con estradiol en gel o parches (1,5 µg/día), con un seguimiento de 4,8 años, y demostraron un aumento en el grosor de la piel del 7-15 % medido por ecografía. Por otra parte, Haapasaari et al 21 …”

Section: Hormonasunclassified

Envejecimiento cutáneo: causas y tratamiento

González‐Guerra¹,

Alcalá²,

Guerra‐Tapia³

2017

Más Dermatol

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El envejecimiento en general, y el cutáneo en particular, es un proceso deletéreo y universal, que, sin embargo, admite diferencias individuales en función de las causas que actúan sobre el proceso. No existe una causa única, admitiéndose diferentes teorías, entre las que se encuentran las teorías no estocásticas (no azarosas), como es la genética, en la que se incluye la de la senescencia replicativa y la de los gerontogenes; y las teorías estocásticas (azarosas), que hacen referencia al daño ambiental acumulativo a través de la oxidación y la glicación producida por tabaco, sol, contaminación y otros factores entre los que se encuentra el factor hormonal.La prevención se fundamenta en una dieta sana, ejercicio físico y evitación de los factores ambientales como el tabaco y el sol mediante la fotoprotección. En el tratamiento, se consideran la terapia hormonal sustitutiva, los cosméti-cos y cosmecéuticos, las técnicas intervencionistas que se practican en la consulta (mesoterapia, implantes o rellenos, toxina botulínica, peeling químico, láser e hilos tensores) y la cirugía estética.Palabras clave: vejez, envejecimiento cutáneo, causas, teoría estocástica, teoría no estocástica, fotoprotección, hormonas, cosméticos, rejuvenecimiento, técnicas dermoestéticas. AbsTRACTAging in general, and cutaneous in particular, is a deleterious and universal process, which nevertheless admits individual differences depending on the causes that act on the process. There is no single cause, with different theories being accepted, such as non-stochastic (non-random) theories such as genetics, including replicative senescence and gerontogenes, and stochastic (random) theories that refer to cumulative environmental damage through oxidation and glycation produced by tobacco, sun, pollution and other factors including hormone factor.Prevention is based on a healthy diet, physical exercise and avoidance of environmental factors such as tobacco

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“…Skin biopsies were taken from the thigh thus eliminating confounding factors such as sun exposure and smoking (Maheux et al 1994). Other authors have also demonstrated increased skin thickness following HRT (Brincat et al 1985;Callens et al 1996;Sator et al 2001).…”

Section: Hormone Replacement Therapymentioning

confidence: 99%

Effect of estrogens on skin aging and the potential role of SERMs

Stevenson

Thornton

2007

CIA

126

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Abstract:In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have signifi cant effects on skin physiology and modulate epidermal keratinocytes, dermal fi broblasts and melanocytes, in addition to skin appendages including the hair follicle and the sebaceous gland. Importantly, skin aging can be signifi cantly delayed by the administration of estrogen. This paper reviews the effects of estrogens on skin and the mechanisms by which estrogens can alleviate the changes due to aging that occur in human skin. The relevance of estrogen replacement therapy (HRT) in postmenopausal women and the potential value of selective estrogen receptor modulators (SERMs) as a therapy for diminishing skin aging are also highlighted.

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Does Hormonal Skin Aging Exist? A Study of the Influence of Different Hormone Therapy Regimens on the Skin of Postmenopausal Women Using Non-Invasive Measurement Techniques

Cited by 169 publications

References 0 publications

Skin and brain age together: The role of hormones in the ageing process

Skin and brain age together: The role of hormones in the ageing process

Envejecimiento cutáneo: causas y tratamiento

Effect of estrogens on skin aging and the potential role of SERMs

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