Does Hepatitis E Viral Load and Genotypes Influence the Final Outcome of Acute Liver Failure during Pregnancy

High viral load and deregulation of the progesterone receptor signaling pathway: Association with Hepatitis E-related poor pregnancy outcome

“…Apart from the above discussed host factors, our study shows that viral factors also play a major role in HEV disease severity as reported earlier in the study done by Kar et al [6]. A comparatively higher HEV viral load was observed in FHF patients (139,994.0 ± 103,104.17 copies/ml) than AVH patients (768.92 ± 1105.40 copies/ml).…”

“…Common complications during pregnancy may include death of the mother and fetus, abortion, premature delivery, or death of a live-born baby soon after birth [5]. FHF during pregnancy is associated with higher viral load of HEV compared to AVH [6].…”

Acute painless hepatitis in pregnancy--a cause for concern?

“…Significantly higher HEV viral loads have been reported in pregnant patients than in non-pregnant patients. 8 Genotypes 1 and 4 are thought to have a greater association with adverse outcomes, but this has not been proved. Host factors relate to the alteration in immunological status and steroid concentrations during pregnancy.…”

Infections in Pregnancy

“…113 The severity of infection appears to be exacerbated by folate deficiency, which commonly complicates pregnancy in underdeveloped countries. Like hepatitis A, HEV may cause fulminant hepatitis, encephalopathy, and death.…”