Infections in Pregnancy

Sordillo, Emilia Mia; Polsky, Bruce

doi:10.1016/b978-0-12-374271-1.00047-2

Cited by 1 publication

(1 citation statement)

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“…There are many routes of transmission, including arthropodborne, blood transfusion, organ transplantation, needlestick injury and vertical transmission 4. Dengue infection can lead to increased vascular permeability and endothelial leakage, which damages the placenta, contributing to vertical transmission of the virus 5. The vertical transmission rate varies across the scientific literature, ranging between 1.6% and 22.7% 6 7.…”

Section: Introductionmentioning

confidence: 99%

Vertical dengue transmission complicated with neonatal encephalitis

Usama,

Assawawiroonhakarn,

Soonsawad

2023

BMJ Case Rep

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Vertical transmission of the dengue virus is rare and infrequently reported in the literature. We report the case of a term newborn presented with high-grade fever, generalised petechial rash and hepatomegaly at the age of 5 days, with a history of dengue fever in the mother at 3 days before delivery. The diagnosis was nearly missed because the infant’s dengue NS1 antigen test was initially negative and subsequently positive. After the convalescent phase, the infant developed a new-onset fever with lethargy and drowsiness. Dengue encephalitis was diagnosed with support from a positive dengue reverse-transcriptase PCR in the cerebrospinal fluid. This report has shown the importance of clinical awareness. Early recognition of congenital dengue and vigilant monitoring will contribute to appropriate early management and decrease neonatal morbidity and mortality.

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Section: Introductionmentioning

confidence: 99%