Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?

Mayerat, C.; Mantegani, A.; Frei, P. C.

doi:10.1046/j.1365-2893.1999.00174.x

Cited by 230 publications

(208 citation statements)

References 24 publications

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“…[6][7][8] Recently, it has been suggested that the HBV genotype is correlated with the clinical features of HBV infection. [13][14][15][16][17][18][19] With regard to genotypes B and C, which are prevalent in East Asia, genotype C has been shown to be more frequently found in severe liver disease, 15,17 whereas genotype B is associated with faster HBe seroconversion. [15][16][17][18][19] To investigate these associations further, we have examined the influence of HBV genotypes on the mode of progression of liver disease in patients with chronic HBV infection.…”

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Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

et al. 2003

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To investigate the hepatitis B virus (HBV) genotype-related differences in the progression of liver disease, 585 patients with chronic HBV infection including 258 with histologically verified chronic liver disease (CLD) and 74 with hepatocellular carcinoma (HCC) were examined. The mean ages of both patients with advanced fibrosis (F3 or F4) and with HCC were significantly older in genotype B than in genotype C patients (P ‫؍‬ .018, P ‫؍‬ .024, respectively). Both the hepatitis B e antigen (HBeAg) negativity rate at biopsy and the cumulative HBe seroconversion rate in patients with CLD were significantly higher in genotype B patients than genotype C patients (P < .01, P ‫؍‬ .022, respectively). Multivariate analysis revealed that genotype B, presence of precore mutation, high ALT levels, and severe histologic activity were independent factors for HBe seroconversion. Among all the biopsyproven CLD patients, the ratio of patients with advanced fibrosis in genotype B was significantly lower than that in genotype C (4/30 vs. 74/224, respectively; P ‫؍‬ .034). This difference was more remarkable in younger patients (<45 years; 1/25 vs. 47/180, respectively; P ‫؍‬ .020), and there was no difference in older patients (>45 years). The distribution of each genotype between CLD and HCC was very similar (B and C: 11.2% and 87.0% vs. 10.8% and 89.2%, respectively). In conclusion, our results suggest that, although the patients with genotype B experience earlier HBe seroconversion, slower progression of liver fibrosis, and slower development of HCC, the life-long risk of progression to advanced fibrosis and development of HCC may not differ among genotypes B-and C-related chronic liver disease. (HEPATOLOGY 2003;37:19-26.)

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Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

et al. 2003

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“…5,6,10 In Taiwan, a high proportion of asymptomatic carriers have genotype B compared with genotype C, and 60% of the patients with cirrhosis show genotype C. 6 In Europe, most of the patients with genotype A have chronic hepatitis, while most patients with genotype D have acute hepatitis. 11 Therefore, it is important to investigate the HBV genotypes for the study of clinical and virologic characteristics of patients with HBV infection.…”

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Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan

et al. 2001

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The geographic distribution of hepatitis B virus (HBV) genotypes in Japan and its clinical relevance are poorly understood. We studied 731 Japanese patients with chronic HBV infection. HBV genotype was determined by the restriction fragment length polymorphism (RFLP) method after polymerase chain reaction (PCR). Of the 720 patients with positive PCR, 12 (1.7%) were HBV genotype A, 88 (12.2%) were genotype B, 610 (84.7%) were genotype C, 3 (0.4%) were genotype D, and 7 (1.0%) were of mixed genotype. Over 94% of patients on the Japanese mainland had genotype C, while 60% of the patients on Okinawa, the most southern islands, and 22.9% in the Tohoku area, the northern part of the mainland, harbored genotype B. Compared with genotype C patients, genotype B patients were older (53.6 to 42.2 years; P < .01), had a lower rate of positive hepatitis B e antigen (HBeAg) (18.4% to 50.6%; P < .01), and a lower level of serum HBV DNA (5.02 to 5.87 log genome equivalents (LGE)/mL; P < .01). The mean age of the genotype B patients with hepatocellular carcinoma was 70.1 ؎ 9.2 years, compared with 55.2 ؎ 9.7 of genotype C patients (P < .01). These results indicate that genotypes C and B are predominant in Japan, and there are significant differences in geographic distribution and clinical characteristics among the patients with the different genotypes. (HEPATOLOGY 2001;34:590-594.)Hepatitis B virus (HBV), a member of hepadnaviridae, is a circular double-stranded DNA virus, and is one of the major causative agents of chronic liver diseases, especially in Asian and African countries. HBV had formerly been classified into 4 major subtypes, which were defined serologically. 1 However, the classification of HBV by serologic subtype is not rational because of a change of subtype resulting from one point mutation at the S gene. 2 Thus, according to the molecular evolutionary analysis of the genomic DNA sequence, HBV strains isolated in various countries are classified into 7 genotypes: genotypes A to G. 3

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“…There are eight genotypes of HBV (genotypes A to H); and there is some evidence that the long-term prognosis, the initial clinical picture, and the response to treatment may differ depending on which genotype has infected the patient (16). The vast majority of studies comparing the outcomes of patients infected with different genotypes have not compared all four main genotypes, however, and only genotype A has been compared with genotype D and only genotype B has been compared with genotype C (15,23,27).…”

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Clinical and Serological Variation between Patients Infected with Different Hepatitis B Virus Genotypes

2004

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Hepatitis B virus (HBV) has eight genotypes which have distinct geographical distributions. Studies comparing differences in the clinical outcomes of infections caused by strains with genotype-related variations in the HBV genome have largely compared genotypes B and C and genotypes A and D but not all four genotypes. The present study included 196 HBV-infected patients attending an infectious diseases outpatient clinic in Sweden. The age and geographic origin, liver function, HBeAg and anti-HBe status, and the presence or absence of HBV DNA were analyzed for each patient. HBV DNA was detected in 144 patients, and the HBV genotype and the core promoter and precore sequences were determined for the isolates from 101 of these patients. Among the patients who might be considered most likely to be nonviremic, namely, anti-HBe-positive HBV carriers with normal alanine aminotransferase (ALT) levels, 65% had detectable HBV DNA and were thus viremic. Among the viremic patients, HBeAg-positive patients were more likely to have elevated ALT levels than anti-HBe-positive patients. HBV genotypes A to F were represented in the study, and their distributions coincided accurately with the origin of the patient. A significantly higher number of genotype D-infected patients were anti-HBe positive and had elevated ALT levels (42% of genotype D-infected patients but 0% of patients infected with genotypes B and C). Genotype D strains with mutations in the core promoter and precore regions were significantly correlated with elevated ALT levels in the patients. The differences were not age related. Therefore, in this large-scale cross-sectional study, genotype D appears to be associated with more active disease.

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Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?

Cited by 230 publications

References 24 publications

Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease

Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan

Clinical and Serological Variation between Patients Infected with Different Hepatitis B Virus Genotypes

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