Does Helicobacter pylori infection play a role in lung cancer?

Ece, Ferah; Hatabay, Nilgun; Erdal, Nuray; Gedik, Canan; Güney, Cengiz; Aksoy, Ferda

doi:10.1016/j.rmed.2005.02.038

Cited by 31 publications

(26 citation statements)

References 18 publications

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“…Several case–control studies evaluated the association between H pylori and lung cancer, with inconsistent findings and small sample sizes 18–20 22 23. More recently, a prospective study in the α-Tocopherol, β-Carotene Cancer Prevention cohort found no association between H pylori and lung cancer 21.…”

Section: Discussionmentioning

confidence: 99%

Association betweenHelicobacter pyloriand mortality in the NHANES III study

Chen

Segers

Blaser

2013

Gut

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Objective Persistent colonization by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on both total and category-specific mortality. Design We conducted prospective cohort analyses in a nationally representative sample of 9895 participants enrolled in the National Health and Nutrition Examination Survey III (NHANES III) to assess the association of H. pylori status with all-cause and cause-specific mortality. Analyses for the association of H. pylori cagA positivity with mortality were conducted in 7,384 subjects with data on H. pylori cagA status. Results In older individuals (> 40.6 years of age), H. pylori was not associated with all-cause mortality (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.84–1.18). There was an inverse association of H. pylori status with stroke mortality (HR, 0.67; 95% CI, 0.44–1.08), and the inverse association was stronger for H. pylori cagA positivity, with the HR of 0.45 (95% CI, 0.27–0.75). H. pylori also was strongly positively related to gastric cancer mortality. After we adjusted p-values using the Benjamini–Hochberg false discovery rate (FDR) method to account for multiple comparisons, these associations remained, and H. pylori status was not related to other outcomes.. Conclusion Our findings suggest that H. pylori has a mixed role in human health, but is not a major risk factor for all-cause mortality.

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Section: Discussionmentioning

confidence: 99%

Association betweenHelicobacter pyloriand mortality in the NHANES III study

Chen

Segers

Blaser

2013

Gut

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“…A link with H. pylori infection has been sought in only four small case-control studies. Two studies reported a positive association (71,87), whereas the other two found no association. In the studies with null associations, there were no adjustments for important confounders such as smoking or sex (173,192).…”

Section: Effects Mediated Through Human Gastrin Hormonementioning

confidence: 99%

Role of Bacteria in Oncogenesis

2010

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SUMMARY Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.

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“…Moreover, this risk increases inversely with level of pulmonary function expressed as forced expiratory volume in one second [6]. Further, it has been proposed that chronic inflammatory process in the lung may stimulate cell-proliferation and growth, leading to lung cancer [7,8]. Thus, it seems likely that disorders associated with airway inflammation are risk factors for lung cancer.…”

Section: Introductionmentioning

confidence: 99%