Does gradual detorsion protect the ovary against ischemia–reperfusion injury in rats?

Abstract

Gradual detorsion can reduce reperfusion injury in a rat model of ovarian torsion. This method is easily applicable and may be a useful method for human patients with ovarian torsion.

The Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy

“…Sterility is a significant finding that indicates severe ovarian function impairment. Various techniques have therefore been developed in order to reduce reperfusion injury to a minimum [11,14]. Controlled reperfusion (CR) has been shown to be beneficial in the prevention of ovarian ischemic injury [11].…”

Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

“…sildenafil (1.4 mg/ kg) group Arch Gynecol Obstet in the neutrophil infiltration, production of nitric oxide, cytokines and FOR in ovarian tissue [3,15,16]. In this case, it is described as IRD, which actually causes more tissue damage when compared to ischemia [3,4]. Therefore, it is asserted that the use of antioxidant pharmacological agents during or before reperfusion could be useful [17].…”

“…The torsion of the ovarian vascular pedicle around its own axis results in a decrease in the blood flow and the obstruction of lymphatic drainage [4]. A decrease in the blood flow causes an increase lactic acid, hypoxanthine and lipid peroxide level in the ovarian tissue [14,15].…”

“…While the conventional treatment method is the extraction of the torsioned ovary, ovarian detorsion must be implemented for patients in whom the protection of fertility is desired. However, it has been asserted that free oxygen radicals (FOR), which occur after detorsion, cause more damage in ischemic ovarian tissue [1,4,5]. Therefore, to decrease the damage in ovarian tissue exposed to ischemia-reperfusion, the determination of new pharmacological agents is an important clinical target.…”

Adnexal torsion in adolescents

“…The treatment goal is to restore blood flow and improve tissue perfusion in ischemia through detorsion. During reperfusion, tissue damage can be more severe than during ischemia because of oxygenderived radicals (reactive oxygen species) such as hydrogen peroxide, hydroxyl radicals, and nitric oxide, which accumulate after detorsion [37]. This process is known as 'ischemia-reperfusion injury' (I/R injury) and it can determine impairment at systemic and tissue levels [38].…”