Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

Çalışkan, Mustafa; Çaklılı, Özge Telci; Çalışkan, Zuhal; Duran, Cevdet; Çiftçi, Faika Ceylan; Avcı, Enver; Güllü, Hakan; Kulaksızoğlu, Mustafa; Koca, Harun; Müderrisoğlu, Haldun

doi:10.1111/echo.12597

Cited by 17 publications

(16 citation statements)

References 30 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of researchers have focused on the adverse effects of EAT and confirmed this parameter as a marker of diabetic risk [8]. A previous study also revealed that EAT thickness was significantly higher in women with a history of GDM than controls [21]. Subsequently, two cross-sectional studies found a difference in EAT thickness when comparing between GDM and control groups during the second trimester [22,23].…”

Section: Discussionmentioning

confidence: 94%

“…Pregnancy can be viewed as a cardiovascular stress test in that the development of certain complications has the potential to reveal a woman's susceptibility for future vascular or metabolic disease [29]. A previous study showed that GDM patients who had an increased EAT thickness during pregnancy were associated with subclinical atherosclerosis 6 years postpartum [21,30]. The association between EAT and postpartum cardiovascular diseases therefore needs to be addressed further in future research.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epicardial adipose tissue thickness as a potential predictor of gestational diabetes mellitus: a prospective cohort study

Liu

Song

Meng

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: Gestational diabetes mellitus (GDM) is the most common metabolic disorder that can occur during pregnancy and is associated with a long-term risk of both maternal and neonatal comorbidities. This study aimed to investigate the association between echocardiographic epicardial adipose tissue (EAT) and the risk for GDM during the early second trimester of pregnancy. Method: We recruited all singleton pregnancies between January 2014 and December 2018 at 16 weeks + 0 days to 19 weeks + 6 days. We then used generalized linear models to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for EAT as a potential predictor for GDM. Receiver-operating-characteristic (ROC) analysis was then conducted to investigate the discriminative capacity of any individual maternal factor for the prediction of GDM. Results: In total, our study involved 314 pregnant women with GDM and 1832 pregnant women without GDM. Multivariate regression analysis revealed that EAT thickness (OR = 2.87; 95% CI: 2.49-3.31) was significantly associated with the presence of GDM (P < 0.001). Furthermore, EAT thickness was also significantly associated with a range of adverse outcomes in the GDM group, including large size for gestational age, neonatal hypoglycemia, admission to the neonatal intensive care unit, preterm delivery, and hyperbilirubinemia (P < 0.001). ROC analysis revealed that the area under the curve was 0.790 (95% CI: 0.768-0.812). When the cutoff value for EAT thickness was set to 5.49 mm, the sensitivity was 95.2% and the specificity was 50.5%. Conclusions: Echocardiographic EAT thickness is positively and significantly associated with both the risk of GDM and adverse outcomes related to GDM. Echocardiographic EAT has the potential to predict GDM prior to actual clinical diagnosis.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Epicardial adipose tissue thickness as a potential predictor of gestational diabetes mellitus: a prospective cohort study

Liu

Song

Meng

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…[12,13] However, very few studies examined the association between UA and postpartum diabetes risk among women with a history of GDM, especially among Chinese women. Several studies showed that UA could be applied in predicting diabetes risk among participants with IGT or IFG.…”

Section: Discussionmentioning

confidence: 99%

“…[11] Some studies on women with prior GDM indicated that this group of people exhibit elevated levels of UA. [12,13] Only one recent case-control study first demonstrated that higher UA levels may be associated with type 2 diabetes among women with a history of GDM compared with those without GDM. [14] Furthermore, most of previous studies were conducted among Caucasians diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

Leng

Wang

et al. 2017

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

Aims To assess the association of uric acid (UA) with the risks of postpartum type 2 diabetes and prediabetes among women with prior gestational diabetes mellitus (GDM). Methods We performed a cross-sectional study of 1262 GDM women at 1–5 years after delivery using the baseline data from the Tianjin Gestational Diabetes Mellitus Prevention Program. Logistic regression models were used to estimate the association of different levels of serum UA with the risks of type 2 diabetes and prediabetes. Results The multivariable-adjusted odds ratios (ORs) across quartiles of serum UA were 1.00, 1.23 (95% confidence interval [CI] 0.55–2.78), 2.05 (95% CI 0.96–4.39), and 3.17 (95% CI 1.54–6.55) (Ptrend<0.001) for type 2 diabetes, and 1.00, 1.50 (95% CI 1.03–2.19), 2.28 (95% CI 1.58–3.30), and 2.88 (95% CI 1.99–4.17) (Ptrend<0.001) for prediabetes, respectively. Restricted cubic splines models showed positive linear associations of serum UA as a continuous variable with the risks of type 2 diabetes and prediabetes. This positive association was significant when stratified by healthy weight and overweight participants. Conclusions Serum UA levels have a graded positive association with the risks of type 2 diabetes and prediabetes among Chinese with a history of GDM.

show abstract

“…Echocardiographic EAT has a close relationship with IR and inflammatory, can reflect the metabolic effects of IR [35]. Moreover, in women who are normoglycaemic before pregnancy but go on to develop GDM in the late gestation, there is an evidence of decreased peripheral insulin sensitivity before conception [36].…”

Section: Inflammatorymentioning

confidence: 99%

Epicardial adipose tissue thickness as a predictor of gestational diabetes mellitus: a prospective cohort study

Liu

Song

Meng

et al. 2019

Preprint

View full text Add to dashboard Cite

BackgroundGestational diabetes mellitus (GDM), the most common metabolic disorder of pregnancy, is a long term risk of comorbidities for maternal and neonatal. The study aimed to assess the association between the echocardiographic epicardial adipose tissue (EAT) and the risk for gestational diabetes mellitus (GDM) in the early second trimester.MethodsSingleton pregnancies were enrolled in this study between September 2017 and January 2019 during their 16–20 gestational week. Odds ratio (OR) and 95% confidence intervals (CIs) of individual maternal factors as potential predictors for GDM were calculated using generalized linear models. The receiver-operating-characteristic (ROC) analysis was conducted to assess the discriminative capacity of any individual maternal factor in predicting GDM.Results69 GDM and 420 normal women were included in the main analysis. Multivariate regression analysis revealed that EAT thickness (OR = 1.96, 95%CI: 1.50–2.55) and high-density lipoprotein cholesterol (OR = 0.21, 95%CI: 0.05–0.84) were associated with the presence of GDM (P < 0.05). Meanwhile, EAT thickness was associated with adverse outcomes (including large for gestational age, neonatal hypoglycemia, admission to neonatal intensive care unit, preterm delivery, and hyperbilirubinemia) in the GDM group (P < 0.05). ROC analysis revealed that the area under curve was 0.698 and the cutoff value is 6.77mm only using EAT thickness. After added high-density lipoprotein cholesterol into the analysis, the area under curve was increase into 0.713.ConclusionsEchocardiographic EAT thickness is positively and significantly associated with GDM risk and adverse outcomes related to GDM. Echocardiographic EAT is a simple method to predict the development of GDM prior to actual clinical diagnosis. This method provides a new early window of opportunity to implement primary prevention strategies to prevent GDM and reduce the related adverse maternal and perinatal outcomes.

show abstract

Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

Abstract: Although the number of patients included in this study is limited, high EFT results may indicate presence of atherosclerosis in women with previous GDM.

Cited by 17 publications

References 30 publications

Epicardial adipose tissue thickness as a potential predictor of gestational diabetes mellitus: a prospective cohort study

Epicardial adipose tissue thickness as a potential predictor of gestational diabetes mellitus: a prospective cohort study

Uric acid and diabetes risk among Chinese women with a history of gestational diabetes mellitus

Epicardial adipose tissue thickness as a predictor of gestational diabetes mellitus: a prospective cohort study

Contact Info

Product

Resources

About