Does gender really matter in contaminant exposure? A case study using invertebrate models

McClellan‐Green, Patricia; Romano, Jocelyn; Oberdörster, Eva

doi:10.1016/j.envres.2006.09.008

Cited by 48 publications

(19 citation statements)

References 40 publications

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“…Several previous works have reported differences in sensitivity between males and females when exposed to pollutants. A wide range of responses have been observed by McClellan-Green et al [40] in a study of sex-related changes and toxicity in invertebrates. These responses included increased resistance in females, decreased molting in males, and alterations in reproductive and physiological metabolism by critical enzymes.…”

Section: Increasing Temperature Effectsmentioning

confidence: 83%

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

Greco

Pellerin

Capri

et al. 2010

Enviro Toxic and Chemistry

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Abstract-The aim of the current study was to investigate effects of temperature and a mixture of herbicides on the physiological status of the bivalve Mya arenaria. Bivalves acclimated to two temperatures (7 and 188C) were exposed for 28 d to 0.01 mg/L of a pesticide formulation containing dichlorophenoxyacetic acid (2,4-D), 2-(2-methyl-4-chlorophenoxy) propionic acid (mecoprop), and 3,6-dichloro-2-methoxybenzoic acid (dicamba). At days 7, 14, and 28, mortality, immune parameters (hemocyte number, phagocytic activity, and efficiency), biomarkers of oxidative stress (catalase [CAT] and superoxide dismutase [SOD] activities and malondialdehyde [MDA] content), the metabolic enzyme cytochrome C oxidase (CCO), a biomarker of pesticide exposure (acetylcholinesterase [AChE]), and the activity of an enzyme related to gametogenesis (aspartate transcarbamylase [ATCase]) were monitored in clam tissues. Gonadosomatic index (GSI), condition factor (CF), and sex were also assessed. In clams acclimated to 78C, exposure to pesticide enhanced CCO activity and CF and decreased MDA content, hemocyte number, CAT, and SOD activities. In clams kept at 188C, pesticide effects appeared minor compared with samples kept at 78C. In bivalves acclimated to 188C, CCO, SOD, and ATCase activity and MDA content were enhanced, and hemocyte number, CAT, and AchE activities and phagocytosis were suppressed. In samples exposed to pesticides, increased temperature enhanced MDA content and CCO and SOD activity and suppressed hemocyte number and CAT and AchE activity. A gradual sexual maturation was observed in both sexes through experimental time, but females had a higher sensitivity to temperature and pesticides compared to males. Increased temperature altered the ability of the sentinel species Mya arenaria to respond to pesticide exposures. Further work is needed to understand the impacts of increasing temperature on the whole St. Lawrence estuary ecosystem. Environ. Toxicol. Chem. 2011;30:132-141. # 2010 SETAC

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Section: Increasing Temperature Effectsmentioning

confidence: 83%

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

Greco

Pellerin

Capri

et al. 2010

Enviro Toxic and Chemistry

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“…When immunized with honeybee venom, females show a more enhanced and prolonged immunological response compared to males (McCllelan-Green et al, 2007). Differences in the reaction of sexes to treatment may result from differences in uptake, metabolism and elimination of a toxicant.…”

Section: Discussionmentioning

confidence: 99%

Capsazepine affects thermal preferences of the American cockroach (Blattodea: Blattidae)

Maliszewska¹,

Tęgowska²

2016

Eur. J. Entomol.

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ISSN (online): 1802-8829http://www.eje.cz capsaicin induces preferences for lower temperatures in Rhodnius prolixus, while capsazepine treatment cause the opposite behaviour.The aim of our study was to assess the effect of capsazepine (TRPV1 antagonist) on the thermal preference of the American cockroach, Periplaneta americana. American cockroach has TRP receptors. Wicher et al. (2005) screened the Periplaneta cDNA library for members of the TRPC family and found a homolog of the Drosophila TRPɣ channel. It is proposed that it is involved in forming the channel that conducts the Ca 2+ background current in DUM neurons. Recently, French et al. (2015) demonstrated that the TRPL channel has a major role in Periplaneta phototransduction.Based on our preliminary results we hypothesized that capsazepine infl uences thermoregulatory processes in insects. To confi rm this hypothesis, we examined thermal preferences of cockroaches treated with fi ve different capsazepine concentrations and released in a thermal gradient system. To establish whether capsazepine may act as a capsaicin antagonist in insects, we assessed the insect thermoregulatory response to capsaicin following pretreatment with capsazepine. We assumed that capsazepine blocks the insects' hypothermic response to capsaicin, as in mammals (Dogan et al., 2004). MATERIALS AND METHODS InsectsAmerican cockroaches Periplaneta americana L. were reared in plastic containers at ~ 26°C under a natural photoperiod. They were fed with oat fl akes and apples and received drinking water at regular intervals. Only adult individuals were selected for the experiments. Experiments were performed separately on males Abstract. Capsazepine is a competitive antagonist of capsaicin, a TRPV1 agonist responsible for the spicy taste of pepper. TRPV1 agonists and antagonists are known to affect mammalian body temperature, but their action on thermoregulation in insects is poorly known. In this study we evaluated the effect of capsazepine on the thermal preference of the American cockroach, Periplaneta americana using a thermal gradient. Our results revealed that capsazepine in submicromolar concentrations induces a preference for higher ambient temperatures when compared to the control insects. To assess whether capsazepine may act also as an antagonist of capsaicin in insects, we determined this insects' thermal behaviour when capsazepine was applied before capsaicin. The hypothermic response to capsaicin was clearly blocked by pre-treatment with capsazepine only in female American cockroaches. Our results indicate the involvement of structures functionally similar to TRPV1 in insect thermosensation.

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“…Inability to noninvasively determine sex in early-life stage individuals has precluded the observation of any sex-based differences in larval OA sensitivity. It is therefore unclear whether sex-based differences are more or less pronounced during early-life stages than in adults [9]. Importantly, any differential mortality, or OA sensitivity, in larval stages could significantly impact the sex ratio of larval recruits, and thus population dynamics [17], as demonstrated in knobbled whelks [22].…”

Section: Resultsmentioning

confidence: 99%

“…However, despite recent evidence that many physiological, behavioural, immunological, molecular and neuro-toxicological functions are influenced by sex-based differences [9,10], and despite many of these same processes being impacted by elevated pCO 2 [5], the overarching role of sex in determining response to OA remains understudied [11]. Here, we employ a systematic map approach: a transparent, robust and repeatable method to identify and collect relevant literature to answer the question of how sex is considered within experimental OA research [12].…”

Section: Introductionmentioning

confidence: 99%

Does sex really matter? Explaining intraspecies variation in ocean acidification responses

et al. 2017

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A contribution to the special feature 'Ocean acidification'. Ocean acidification (OA) poses a major threat to marine ecosystems globally, having significant ecological and economic importance. The number and complexity of experiments examining the effects of OA has substantially increased over the past decade, in an attempt to address multi-stressor interactions and long-term responses in an increasing range of aquatic organisms. However, differences in the response of males and females to elevated pCO 2 have been investigated in fewer than 4% of studies to date, often being precluded by the difficulty of determining sex non-destructively, particularly in early life stages. Here we highlight that sex can significantly impact organism responses to OA, differentially affecting physiology, reproduction, biochemistry and ultimately survival. What is more, these impacts do not always conform to ecological theory based on differential resource allocation towards reproduction, which would predict females to be more sensitive to OA owing to the higher production cost of eggs compared with sperm. Therefore, non-sex-specific studies may overlook subtle but ecologically significant differences in the responses of males and females to OA, with consequences for forecasting the fate of natural populations in a near-future ocean.

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Does gender really matter in contaminant exposure? A case study using invertebrate models

Cited by 48 publications

References 40 publications

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

Physiological effects of temperature and a herbicide mixture on the soft‐shell clam Mya arenaria (Mollusca, Bivalvia)

Capsazepine affects thermal preferences of the American cockroach (Blattodea: Blattidae)

Does sex really matter? Explaining intraspecies variation in ocean acidification responses

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