Does formaldehyde cause nasopharyngeal cancer in man?

Purchase, I. F. H.; Paddle, G.M.

doi:10.1016/0304-3835(89)90013-x

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…Dose-dependent induction of squamous cell carcinoma of nasal passages [23] is in agreement with the study confirming occurrence of nasal tumors only at high doses of 14 and 15 ppm in rats and also described a potential induction of substantial histopathological derangements directly associated with the development of nasal tumors at 6 ppm and above, with a sufficient duration [24]. Treatment of 10 ppm formaldehyde concentration with sufficient exposure duration also indicated hyperchromatic nasal glands, in rats [25].…”

Section: Carcinogenic Effect Of Formaldehyde Exposure In Nasopharynxsupporting

confidence: 85%

Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants

Tesfaye

Hamba

Gerbi

et al. 2021

Alexandria Journal of Medicine

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Background: Formaldehyde (FA) is a sensitizing agent that can produce an effective immune system response upon initial exposure. FA that can be used in many industries, medical and anatomical facilities, mainly cadaver-based gross anatomy laboratories, represent a risk to occupational health of professionals and students. The majority of FA exposures occur through inhalation, dermal, and eye contact. FA-induced effects are attributed to site-specific and dosedependent health impairments in many organs and organ systems. Much progress has been reported on FA-induced health impairments in respiratory tract, but a comprehensive study in different organ systems and the reverse effects of some novel antioxidants is still lacking. This review explores the cytotoxic effects of FA and its role as key signaling molecule, site specific and or dose dependent effects of FA in nasal cavity, carcinogenic effects of FA exposure in nasopharynx, effects of FA in lung macrophage functions and development of pulmonary fibrosis, dose dependent reproductive and genetic effects of FA, neurotoxic effects of FA and potential risk of FA in some beauty salons and cosmetic products. In addition, this study shows the counteracting beneficial role of melatonin, Nigella sativa, rose oils, caffeic acid phenethyl ester (CAPE), vitamin E, and proanthocyanidins (PAs) against FA induced tissue damage. Methods: A comprehensive literature search highlighting the health impairments of FA and counteracting beneficial effects of promising antioxidants was conducted using PubMed, Google Scholar, and Medline Cochrane, to assemble relevant publications from open access international journals published only in English. Results: The search generated 411 articles of which 70 full research articles fulfilled the inclusion criteria and included in the review. The results of this study confirmed relentless toxic effects of FA exposure on various organs of human and other animals. Multiple findings also stated the efficacy of promising antioxidants against FA-induced tissue damage in animal models. Conclusion:Occupational exposure to FA is most likely due to inattention towards its side effects and lack of appropriate air filtering equipment or unmonitored concentration of FA in the working air. Therefore, re-evaluating the concentration of FA, proper ventilation, and assessment of working practices is highly recommended. Proper monitoring is also needed to improve compliance and protection of FA-based reproductive complications in females. Despite complete prevention is not viable, exposed personnel must be aware of FA-induced health effects and require assessing risks and acquiring practical measures in their working environment.

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Section: Carcinogenic Effect Of Formaldehyde Exposure In Nasopharynxsupporting

confidence: 85%

Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants

Tesfaye

Hamba

Gerbi

et al. 2021

Alexandria Journal of Medicine

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“…Both the disposition of formaldehyde and , possibly, the tumorigenic response seem to be species dependent among rodents alone, as no carcinogenicity was demonstrated in hamsters (35) in an exposure scenario comparable with that of the rat experiments; and the effects on mice were much less pronounced than those on rats (33). The latter finding has been explained simply by the fact that, when exposed to formaldehyde, the mouse reduces its breathing volume substantially more than the rat, and therefore also lowers the amount of exposure (36).…”

Section: Discussionmentioning

confidence: 99%

Formaldehyde exposure and respiratory cancer--a meta-analysis of the epidemiologic evidence.

Partanen¹

1993

Scand J Work Environ Health

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“…While one review and two metaanalyses of the available epidemiologic evidence concluded that nasopharyngeal cancer (NPC) is associated with formaldehyde exposure (International Program on Chemical Safety, 1989;Blair et al, 1990;Partanen, 1993), a recent meta-analysis of 47 studies concluded that the available studies do not support a causal association (Collins et al, 1997). Other reviews have concluded that insufficient evidence exists for a causal relation between formaldehyde exposure and cancer risk (Purchase and Paddle, 1989;McLaughlin, 1994). The International Agency for Research on Cancer (IARC) recently classified formaldehyde as a 'probable' (2A) human carcinogen based on limited human evidence and sufficient animal evidence (International Agency for Research on Cancer, 1995).…”

Section: Introductionmentioning

confidence: 99%

Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde

et al. 2002

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Does formaldehyde cause nasopharyngeal cancer in man?

Cited by 10 publications

References 16 publications

Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants

Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants

Formaldehyde exposure and respiratory cancer--a meta-analysis of the epidemiologic evidence.

Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde

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