Does fenugreek ( Trigonella foenum-graecum ) seed improve inflammation, and oxidative stress in patients with type 2 diabetes mellitus? A parallel group randomized clinical trial

Tavakoly, Rahele; Maracy, Mohammad Reza; Karimifar, Mozhgan; Entezari, Mohammad Hasan

doi:10.1016/j.eujim.2018.01.005

Cited by 44 publications

(17 citation statements)

References 31 publications

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“…It is interesting to note that treatments related to the liver are more often proposed to the elderly population [28]. A previous study has reported that Fenugreek extract improved lipid metabolism [29] and a clinical study has shown that antioxidant capacity can be improved by the fenugreek seeds as well [30].…”

Section: Discussionmentioning

confidence: 99%

Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

et al. 2020

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Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (p < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.

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Section: Discussionmentioning

confidence: 99%

Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

et al. 2020

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“…Apart from this, the ageing is also key risk factor in numerous specific hepatic diseases including non-alcoholic fatty liver disease (NAFLD) [20]. It is interesting to note that treatment related to liver are more often proposed to elderly population [21].Previous study has reported that Fenugreek extract improved lipid metabolism [22] and a clinical study has shown that antioxidant capacity can be improved by the fenugreek seeds as well [23]. In a study conducted to evaluate the protective effect of fenugreek seeds against ethanol toxicity, Thirunavukkarasu et al…”

Section: Discussionmentioning

confidence: 99%

Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Tewari¹,

Jóźwik²,

Łysek-Gładysińska³

et al. 2020

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Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, Fenugreek seeds are also widely recommended for the geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12 months aged mice which were given fenugreek seed dietary supplement. We have evaluated the activities of various antioxidant defense enzymes like superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx and GR activities in aged mice liver revealed a significant (P<0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect in on the activities of the hepatic antioxidant defense enzymes in the aged mice.

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“…In a study with 114 T2DM patients (Geberemeskel, Debebe, & Nguse, 2019), a fenugreek powder solution, orally consumed for 30 consecutive days, was able to significantly improve the lipid profile of these patients compared with a placebo control. The effect of fenugreek on inflammation and oxidative stress was also investigated in a limited human study (Tavakoly, Maracy, Karimifar, & Entezari, 2018). After consuming fenugreek seed for 8 wk, these T2DM patients showed a significant decrease in high-sensitivity C-reactive protein and a significant increase in serum superoxide dismutase activity compared with the control group that did not consume any.…”

Section: Crop Sciencementioning

confidence: 99%

Canadian sainfoin and fenugreek as forage and functional foods

et al. 2020

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Sainfoin (Onobrychis viciifolia Scop.) and fenugreek (Trigonella foenum‐graecum L.) are two legumes that are being developed as forage crops in Canada with potential benefits for animal and human health. Sainfoin, a perennial crop containing condensed tannins (CTs), is gaining popularity in western Canada because of its benefits for cattle. Its CTs make the crop bloat‐free for grazing cattle while improving protein digestibility and reducing greenhouse gas emissions. The CT‐containing fenugreek is also considered as a bloat‐free annual forage legume that was developed to serve in short‐term crop rotations in western Canada. These crops are known to provide health and nutritional benefits to cattle with their high protein content and other beneficial nutraceuticals such as crude fiber, 4‐hydroxyisoleucine, steroid sapogenins, and galactomannans. Some of these nutraceuticals have the potential to benefit human health; however, such attributes have not been studied enough to harness the full potential of these legume crops in Canada. Recent research suggests that legumes are a healthy substitute for meat. However, metabolite analysis of sainfoin is mostly limited to proteins and CTs. The CTs reported in sainfoin are involved in reduction of blood pressure and detoxification and providing anticancer properties in humans. Recent studies on fenugreek have highlighted the beneficial nutraceuticals associated with human health but most of those claims are not backed by relevant clinical studies. In this article, we reviewed the nutritional quality attributes of sainfoin and fenugreek and assessed their potential as functional foods and nutraceuticals for animal and human health based on scientific evidence.

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Does fenugreek ( Trigonella foenum-graecum ) seed improve inflammation, and oxidative stress in patients with type 2 diabetes mellitus? A parallel group randomized clinical trial

Cited by 44 publications

References 31 publications

Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Fenugreek (Trigonella foenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Fenugreek (Trigonellafoenum-graecum L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice

Canadian sainfoin and fenugreek as forage and functional foods

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