Does exogenous magnesium suppress myocardial irritability and tachyarrhythmias in the nondigitalized patient?

2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

“…Hipokaliemia z hipomagnezemią lub bez niej (wywołana stosowaniem tiazydów i diuretyków pętlowych) może być odpowiedzialna za komorowe zaburzenia rytmu u pacjentów z nadciśnieniem tętniczym i zastoinową HF [774]. Wiele czynników, takich jak bradykardia, niedokrwienie, skurcz tętnic wieńcowych, zakrzepica, ostre głodzenie [776] oraz ostre toksyczne działanie alkoholu lub odstawienie alkoholu [777,778], może sprzyjać występowaniu VA i SCD. Również ICD może być przyczyną pojawienia się komorowych zaburzeń rytmu [779][780][781].…”

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death

“…Hypomagnesemia is classically associated with polymorphic VT or torsades de pointes, which together with ventricular arrhythmias in an AMI setting may respond to intravenous magnesium (868 -871). Hypokalemia with or without hypomagnesemia may be responsible for ventricular arrhythmias in subjects with hypertension and congestive cardiac failure (precipitated by the use of thiazide and loop diuretics) (855,856,872), acute starvation (873), acute alcohol toxicity/withdrawal, and those with ventricular arrhythmias associated with digoxin and other Vaughan Williams class 1 antiarrhythmic drugs (865,874,875). Significant hypocalcemia can prolong the QT interval.…”

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death—Executive Summary

“…Hypomagnesemia is classically associated with polymorphic VT or torsades de pointes, which together with ventricular arrhythmias in an acute MI setting, may respond to intravenous magnesium (241)(242)(243)(244). Hypokalemia with or without hypomagnesemia may be responsible for ventricular arrhythmias in subjects with hypertension and congestive cardiac failure (precipitated by the use of thiazide and loop diuretics) (227,228,245), acute starvation (246), acute alcohol toxicity/withdrawal, and those with ventricular arrhythmias associated with digoxin and other Vaughan Williams class III antiarrhythmic drugs (238,247,248). Significant hypocalcemia can prolong the QT interval.…”