Does ethanol metabolism affect erythrocyte hemolysis?

Abstract

The effects of ethanol and acetaldehyde on the hemolytic stability of rabbit erythrocytes have been compared. Incubation of normal erythrocytes with ethanol facilitated both acidic and oxidative hemolysis and increased the percentages of cells that were hemolyzed at maximal rate. Acetaldehyde exerted a similar destabilizing effect on erythrocytes only in the case of oxidative hemolysis. The destabilizing effect of ethanol was observed in catalase-inactivated erythrocytes under acidic, but not oxidative, hemolysis conditions. It is concluded that the destabilizing effect of unmetabolized ethanol occurs under conditions of acidic hemolysis, whereas the destabilizing effect of the oxidation of ethanol to acetaldehyde takes place only under the conditions of oxidative hemolysis.

Antioxidant effect of EGb 761 on hydrogen peroxide‐induced lipoperoxidation of G‐6‐PD deficient erythrocytes

“…The reported antioxidant effects of EGb 761 have been observed usually in tissues either from pathological conditions or subjected to peroxidative stress Dogan, 1995a, 1995b;Pietri et al, 1997;Seif-El-Nasr and El-Fattah, 1995), whereas in the present study the oxidative effect of EGb 761 was observed in the tubes that were not exposed to H 2 O 2 . A similar TBARS increasing effect of directly applied vitamin E was also seen but it can be attributed to the oxidative haemolysis facilitating effect of its vehicle, absolute ethanol (Tyulina et al, 2000).…”

The effect of ethanol on erythrocyte carbonic anhydrase isoenzymes activity: An in vitro and in vivo study

“…In fact, the ethanol causes several haemolytic disorders due to both direct and indirect effects [13]. Additionally, the ethanol metabolite acetaldehyde inside of the erythrocyte has the ability to generate free radical species and to cause deleterious effects on erythrocytes [26]. Although several effects of the ethanol and its metabolites on erythrocytes have been reported previously, there has been no report to analyse its effects on erythrocyte CA enzymes.…”

Glucose-6-Phosphate Dehydrogenase Deficiency and Malaria: A Method to Detect Primaquine-Induced Hemolysis in vitro

“…24-48 hours after ingesting foods like fava beans, characteristic symptoms occur in the form of pallor, jaundice and hemoglobinuria (Ninfali, et al, 2000). In addition, jaundice, headache, backache, nausea, fever, and chills are all signs of acute hemolysis (Tyulina, et al, 2000). Favism is most common seen in children between the ages of 2-5, and is also 2-3 times more common in boys than in girls (Luzzatto, 2001).…”