To examine instructional communication behaviors in the medical context and to explore the role of health literacy in pediatrician-parent relationships, the current study assessed parents' (N ¼ 299) perceptions of their pediatricians' nonverbal immediacy, clarity, and verbal receptivity and their own communication satisfaction, affective learning, and cognitive learning. Results demonstrated that when pediatricians are nonverbally immediate, clear, and verbally receptive, parents report that they are satisfied with their pediatricians' communication, affectively predisposed toward their pediatricians, and able to recall their pediatricians' medical directives. Further, health literacy moderates the relationships between pediatricians' behaviors and parent outcomes such that for parents with low health literacy, pediatricians' use of nonverbal immediacy and verbal receptivity was related to higher affective and cognitive learning.Approximately 80 million adults in the United States struggle with low health literacy or the skills necessary to function effectively in the health care environment (Berkman, Sheridan, Donahue, Halpem, & Crotty, 2011). Low health literacy is consistently associated with more hospitalizations, greater use of emergency care, and poorer ability in demonstrating how to take medicines appropriately and in interpreting health messages (Berkman et al., 2011;Lanning & Doyle, 2010). Importantly, most efforts to understand or improve health literacy have focused on adult patients with very little attention paid to the pediatrician-parent interaction (Janisse,