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This study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe)2 supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to supplementation, at 42, 28, and 14 days prior to calving. The (PhSe)2 group (DDG) was administered 3 μmol/kg of (PhSe)2 in 4 mL of dimethyl sulfoxide (DMSO), while the DMSO and NaCl groups were administered 4 mL of DMSO and 0.9% NaCl, subcutaneously. The calves were evaluated based on their weight, withers height, body condition score 24 h post-birth (0), as well on days 14, 28, 42, 56, 70. Blood samples were also taken to determine serum variables. Calves on the DDG showed higher average levels of total protein, albumin, and globulins on day 0, and the immunoglobulin G level was significantly higher than the other groups on days 0, 14, 56, 70. Maternal supplementation showed immunomodulatory effect on calves, evidenced by the exceptional rates of passive immunity transfer, as well as the enhancement of humoral immunity. Our research offers fresh insights into the immunomodulatory potential of (PhSe)2, making it a viable alternative in facing this challenging phase, rearing dairy calves.
This study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe)2 supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to supplementation, at 42, 28, and 14 days prior to calving. The (PhSe)2 group (DDG) was administered 3 μmol/kg of (PhSe)2 in 4 mL of dimethyl sulfoxide (DMSO), while the DMSO and NaCl groups were administered 4 mL of DMSO and 0.9% NaCl, subcutaneously. The calves were evaluated based on their weight, withers height, body condition score 24 h post-birth (0), as well on days 14, 28, 42, 56, 70. Blood samples were also taken to determine serum variables. Calves on the DDG showed higher average levels of total protein, albumin, and globulins on day 0, and the immunoglobulin G level was significantly higher than the other groups on days 0, 14, 56, 70. Maternal supplementation showed immunomodulatory effect on calves, evidenced by the exceptional rates of passive immunity transfer, as well as the enhancement of humoral immunity. Our research offers fresh insights into the immunomodulatory potential of (PhSe)2, making it a viable alternative in facing this challenging phase, rearing dairy calves.
O objetivo do trabalho foi avaliar o efeito do disseleneto de difenila (PhSe)2, no ganho médio diário, parâmetros bioquímicos e status oxidativo de bezerras de corte submetidas ao desmame convencional. Foram utilizadas 30 bezerras, com seis meses de vida e 152,42±13,75 kg de peso corporal. Foi utilizado um delineamento inteiramente casualizado sendo as unidades experimentais distribuídas em três grupos: grupo controle (GC, n=10): 2 mL de solução de NaCl; grupo dimetilsulfóxido (GDMSO, n=10): 2 mL de dimetilsulfóxido; e grupo disseleneto de difenila (GDD, n=10): 3 µmol kg-1 de (PhSe)2 diluído em 2 mL de dimetilsulfóxido. As coletas e avaliações foram realizadas no M1=basal (-28) e M2 (-14) dia antes do desmame, M3 (0) dia inicial do desmame, M4 (14) e M5 (28) dia após o desmame. Os tratamentos foram administrados no M1, M2 e M3 pela via subcutânea. Todos os animais foram submetidos a condições similares de manejo e alimentação ao decorrer do experimento, tendo livre acesso a água. Os parâmetros avaliados foram: ganho médio diário, proteína total, albumina, globulina, relação albumina:globulina, glutationa reduzida, substâncias reativas ao ácido tiobarbitúrio e capacidade antioxidante total, determinada pelo potencial antioxidante redutor férrico. Dentre os parâmetros avaliados observou-se efeito significativo (P<0,05): no ganho médio diário entre momentos; na albumina entre tratamentos, momentos e interação tratamento x momento; nas globulinas entre momentos e interação tratamento x momento; na relação albumina:globulina entre momentos e interação tratamento x momento; na glutationa reduzida entre momentos e interação tratamento x momento e no potencial antioxidante redutor férrico entre momentos. A administração de disseleneto de difenila em bezerras de corte proporcionou incremento nas variáveis albumina, globulina, relação albumina:globulina e glutationa reduzida durante o desmame convencional, sendo o efeito benéfico do disseleneto de difenila constatado a partir das interações entre tratamento x momentos. Esses resultados demostram que o disseleneto de difenila é uma alternativa as fontes tradicionais de selênio orgânico, e quando utilizado reduziu os desafios vivenciados pelas bezerras de corte durante o desmame convencional.
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