Does conventional phototherapy have any effect on platelet count in full term neonates with indirect hyperbilirubinemia?

Monsef, Alireza; Eghbalian, Fatemeh

doi:10.4236/health.2011.312119

Cited by 9 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean platelet counts have increased in neonates who received phototherapy for 48-72 hours which is contrary to our study. 9 Thrombocytopenia was seen in maximum number of cases during the first 24 hours of phototherapy, and similar findings were noted in a study. 5,2 That rate of fall of platelet count was more in the first 24 hours of phototherapy which is in contrast to our finding.…”

Section: Discussionsupporting

confidence: 85%

“…Platelets which had been briefly exposed to light following photosensitization by hematoporphyrin lost the ability to aggregate and release potassium, acid phosphatase, serotonin and adenosine Shah MH et al Int J Res Med Sci. 2019 Sep;7 (9): [3505][3506][3507][3508][3509] International Journal of Research in Medical Sciences | September 2019 | Vol 7 | Issue 9 Page 3506 triphosphate. Electron photomicrographs of these altered platelets showed depletion of cytoplasmic materials and smooth membrane contours as compared to controls.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Shah¹,

Vedula²,

Roshan

2019

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Thrombocytopenia as a side effect of phototherapy has not been mentioned in the standard literature but was described briefly as isolated case reports after the phototherapy came in vogue in 1958. The purpose of this study was to find the incidence of thrombocytopenia in neonates with uncomplicated indirect hyperbilirubinemia receiving phototherapy in a referral hospital.Methods: This was a prospective cohort study conducted in a referral hospital over a period of 18 months from June 1, 2013 to November 1, 2014.Results: A total of 103 babies were enrolled. The overall incidence of post-phototherapy thrombocytopenia was 45.6% while mild, moderate and severe thrombocytopenia was present in 66%, 21.3% and 12.8% of babies respectively. The lowest platelet count observed was 31,000/mm3 but none of the neonates showed bleeding manifestations. The incidence of thrombocytopenia following phototherapy was significantly higher in preterm babies, infants who received double surface phototherapy, babies who received phototherapy for >72 hours and in babies who received phototherapy on day 2 or 3 of life.Conclusions: Neonates requiring phototherapy for hyperbilirubinemia are at risk of developing thrombocytopenia, hence the treatment should be initiated based on the standard guidelines. Unnecessary use and prolongation of phototherapy should be avoided considering the possible side effects. Platelet count should be monitored particularly in pre-term neonates receiving phototherapy. Neonates receiving double surface phototherapy and those requiring phototherapy for longer duration require more frequent platelet count monitoring.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Shah¹,

Vedula²,

Roshan

2019

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…. DISCUSSION Thrombocytopenia as a side effect following exposure to phototherapy was documented by our study.The overall incidence of thrombocytopenia was 7.5% .this came in agreement with Khera and Gupta, 2011 (5) and Shah et al, 2019 (6) who showed that phototherapy was complicated by thrombocytopenia in 35% and 45.6% of neonates who received phototherapy.In disagreement with our study, the study done by Monsef et al ., 2011 (7) which reported that there was an increase in the platelet count after phototherapy As regarding to severity of thrombocytopenia, our study showed that 3 neonates (33.3%), 4 neonates (44.4%) and 2 neonates (22.2 %) of neonates who developed thrombocytopenia had mild, moderate and severe thrombocytopenia respectively. In disagreement with our study, the study of Khera and Gupta, 2011 (5) showed that majority of neonates had mild thrombocytopenia (74%), moderate and severe thrombocytopenia was seen in 23% and 3% cases respectively.…”

Section: Figure (12)supporting

confidence: 50%

Impact of Phototherapy on Platelet Count in Neonates With Indirect Hyperbilirubinemia

Moktader

Ezzat

Mohamed

et al. 2020

Fayoum University Medical Journal

View full text Add to dashboard Cite

show abstract

“…Similarly, no evidence was found for light-induced oxidative stress during phototherapy in newborns [63]. A recent study on in full term neonates with indirect hyperbilirubinemia reported a statistically significant increase in platelet count after phototherapy [64]. However, the increase was only 1/9 th of the esd.…”

Section: Direct Light Effects On Plateletsmentioning

confidence: 88%

Platelets, photosensitizers, and PDT

Senge

Radomski

2013

Photodiagnosis and Photodynamic Therapy

View full text Add to dashboard Cite

SummaryPhotodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in antiangiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.Abbreviations: ALA --aminolevulinic acid; AMD -age-related macular degeneration; ANET -anti-neovascular therapy; BGF -basic fibroblast growth factor; DHEdihaematoporphyrin ether; EDRF -endothelium-derived relaxing factor; epithelial growth factor -EGF; HIF-1 -hypoxia-inducible factor 1; HpD -haematoporphyrin derivative; IL -interleukin; PAF -platelet activating factor; PDT -photodynamic therapy; PS -photosensitizer; transforming growth factor 1 -TGF-1; TNF -tumor necrosis factor.

show abstract

Does conventional phototherapy have any effect on platelet count in full term neonates with indirect hyperbilirubinemia?

Cited by 9 publications

References 11 publications

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Incidence of thrombocytopenia in neonates receiving phototherapy for indirect hyperbilirubinemia: a prospective cohort study

Impact of Phototherapy on Platelet Count in Neonates With Indirect Hyperbilirubinemia

Platelets, photosensitizers, and PDT

Contact Info

Product

Resources

About