Does conformal therapy improve dose distribution in comparison to old techniques in teleradiotherapy of cervical cancer patients?

Wlodarczyk, H.; Roszak, A.; Cikowska-Woźniak, E.; Bratos, K.; Wojciechowska-Łącka, A.; Skrobała, A.

doi:10.1016/s1507-1367(10)60009-0

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Włodarczyk H et al [14], also concluded that there were significant differences (p<0.05) in dose distributions in critical organs between the 3DCRT and 4 field conventional box techniques. The smallest volumes of critical organs were irradiated using the 4-portal conformal technique.…”

Section: Original Research Articlementioning

confidence: 93%

Dosimetric comparison and clinical correlation between conventional four field radiotherapy versus three-dimensional conformal radiotherapy in cancer cervix

et al. 2019

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Introduction: With sectional imaging, wide variations are reported in pelvic anatomy of individual patients raising concerns over adequate coverage of target volume with conventional radiotherapy based on standard bony landmarks. Three-dimensional conformal radiotherapy (3DCRT) is reported to decrease normal tissue toxicity, along with decrease in chances of geographic miss. Present study is done for dosimetric comparison of Planning Target Volume (PTV) and Organs at Risk (OAR) in cancer cervix patients treated with conventional and conformal radiotherapy along with clinical correlation in terms of side effects and tumor response. Materials and Methods: Fifty patients of cancer cervix underwent planning contrast enhanced CT scan. Target volumes & OAR were contoured. Patients were randomized into conventional & conformal arms. Conventional fields were planned using standard bony landmarks. CT based radiotherapy planning was done for 3DCRT arm. Field sizes &dose volume histogram (DVH) were recorded & compared for target coverage & OAR sparing in both arms. All patients received concurrent chemotherapy followed by brachytherapy. Results: Field sizes used for the 3DCRT plans were significantly larger than those used for the conventional plans (p= 0.000). Optimal PTV coverage was significantly improved using 3DCRT as compared to conventional radiotherapy (p= 0.0001). Dose homogeneity in both arms were almost similar (p= 0.292), while conformity index was better in 3DCRT which was statistically significant between the groups (p= 0.000). Mean dose to the Planning Target Volume was increased significantly in the CT based plan when compared with the standard four field plan (p= 0.0001).Difference in doses to the organs at risk (urinary bladder, and small bowel)and their side effects were statistically significant across both groups. There was no difference in tumor response. Conclusion: The present study showed significantly better target volume coverage & dose homogeneity with 3DCRT which may translate into better local control & survival but longer follow up is required to validate it.

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Section: Original Research Articlementioning

confidence: 93%

Dosimetric comparison and clinical correlation between conventional four field radiotherapy versus three-dimensional conformal radiotherapy in cancer cervix

et al. 2019

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“…In the 3D conformal technique the shape of the planning target volume (PTV), mutual localisation of the target volume and organs at risk are all considered. 5 Dose distribution in the 3D technique allows the acquisition of more information than that in 2D planning. 3D planning exposes the local maximum of the dose distribution (hot spots) or allows localised regions of PTV that are not covered by the reference dose (cold spots).…”

Section: Introductionmentioning

confidence: 99%

Can we obtain planning goals for conformal techniques in neoadjuvant and adjuvant radiochemotherapy for gastric cancer patients?

Leszczyński

Polanowski

Leszczyńska

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Treatment plan comparisonGastric cancer Conformal radiotherapy a b s t r a c tAim: The purpose of this study was to compare conformal radiotherapy techniques used in the treatment of gastric cancer patients. The study is dedicated to radiotherapy centres that have not introduced dynamic techniques in clinical practice. Background:The implementation of multi-field technique can minimise the toxicity of treatment and improve dose distribution homogeneity in the target volume with simultaneous protection of organs at risk (OaRs). Treatment plan should be personalised for each patient by taking into account the planning target volume and anatomical conditions of the individual patient. Materials and methods:For each patient, four different three dimensional conformal plans were compared: 2-field plan, 3-field plan, non-coplanar 3-field plan and non-coplanar 4-field plan. Dose distributions in a volume of 107% of the reference dose, and OaRs such as the liver, kidneys, intestines, spinal cord, and heart were analysed. Results BackgroundGastric cancer is the third most frequent cause of death from cancer worldwide, with 723,027 deaths registered in 2012. 1 The primary treatment modality of gastric cancer is surgery. 16 This treatment strategy is frequently employed in the early stage of cancer. Radical operation (R0) can be performed in approximately 50% of patients because of the diagnosis of cancer in the locally advanced or dispersal stage. Since the INT-0116 study was published, the standard for pT 2-4 N 0-3 or pT 1 N 1-3 gastric cancer is postoperative radiochemotherapy. 2,6 At some oncology centres, R1 surgical resection is also an indication for postoperative radiochemotherapy. 3 Implementation of this scheme enhances both local cure and the 5-year survival by approximately 15% compared with independent surgery treatment. Initially, at many radiotherapy departments, a recommended two dimension (2D) technique using two opposing fields was applied for gastric cancer treatment. The constraint of 2D radiotherapy for the abdominal area is the close localisation of organs at risk such as the kidneys, liver, intestines and spinal cord. Consequently, this radiotherapy induced high hematologic toxicity of the digestive system and was completed earlier than planned in 17% of patients. 4 With recent advances in technology, computer dose distribution calculations have been shown to allow the introduction of three dimension (3D) conformal techniques (conformal radiotherapy; CRT) in common applications. These techniques turn out to be more effective in achieving high, homogeneous dose distribution in the target volume with simultaneous sparing of normal tissues. In the 3D conformal technique the shape of the planning target volume (PTV), mutual localisation of the target volume and organs at risk are all considered. 5 Dose distribution in the 3D technique allows the acquisition of more information than that in 2D planning. 3D planning exposes the local maximum of the dose distribution (hot spots) or allows localised region...

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Zależność pomiędzy zastosowaniem technik napromieniania w radioterapii a uzyskanym rozkładem dawek w raku szyjki lub trzonu macicy – przegląd literatury

Jodda

Urbański

Piotrowski

et al. 2013

Zeszyty Naukowe WCO, Letters in Oncology Science

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Does conformal therapy improve dose distribution in comparison to old techniques in teleradiotherapy of cervical cancer patients?

Cited by 4 publications

References 10 publications

Dosimetric comparison and clinical correlation between conventional four field radiotherapy versus three-dimensional conformal radiotherapy in cancer cervix

Dosimetric comparison and clinical correlation between conventional four field radiotherapy versus three-dimensional conformal radiotherapy in cancer cervix

Can we obtain planning goals for conformal techniques in neoadjuvant and adjuvant radiochemotherapy for gastric cancer patients?

Zależność pomiędzy zastosowaniem technik napromieniania w radioterapii a uzyskanym rozkładem dawek w raku szyjki lub trzonu macicy – przegląd literatury

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