Does Chronic Daily Headache Arise De Novo in Association With Regular Use of Analgesics?

Bahra, Anish; Walsh, Maggie; Menon, Sanjeev; Goadsby, Peter J.

doi:10.1046/j.1526-4610.2003.03041.x

Cited by 259 publications

(193 citation statements)

References 46 publications

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“…Migraine patients are particularly predisposed to develop chronic headache in association with medication overuse [8]. The regular use of symptomatic medications is associated with the development of chronic headache in individuals who have an existing history of migraine; medication overuse per se did not cause the development of headache de novo in patients without previous headache history.…”

Section: Medication Overusementioning

confidence: 99%

Preventing chronicity of migraine

Fanciullacci

Cesaris

2005

J Headache Pain

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Progression during attacksAllodynia, pain resulting from application of a non-noxious stimulus to normal skin, is a recently described symptom of migraine [3]. In fact clinically detectable allodynia, a manifestation of central sensitisation, occurs with high frequency during migraine attacks. Migraine pain progresses along the neural pathway with throbbing head pain occurring early in the attack (sensitisation of first-order neurons), followed by central sensitisation and cutaneous allodynia within the J Headache Pain (2005) 6:331-333

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Section: Medication Overusementioning

confidence: 99%

Preventing chronicity of migraine

Fanciullacci

Cesaris

2005

J Headache Pain

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“…Medication-overuse headache is a major health problem [10]. Patients with migraine and tension-type headache have a higher potential for medicationoveruse headache [11], and relapses of migraine occur in migraineurs who have been placed on analgesics for other ailments. On the contrary, chronic overuse of analgesics does not cause increased headache in non-migraineurs [12,13].…”

Section: Discussionmentioning

confidence: 99%

Medication-overuse headache: citalopram associated with analgesics withdrawal as possible treatment

et al. 2003

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Medication-overuse headaches are a relevant medical and social problem, for which specific treatments have not yet been defined. In patients with chronic daily headache who take analgesics every day, this headache is most likely to be caused by drugs and will vanish with abstinence. Nonetheless, there is anecdotal evidence that selective serotonin reuptake inhibitors (SSRI) are effective in chronic daily headache, because of the concomitant presence of psychiatric comorbidities (depression, anxiety, or a combination of both). Six migraineurs were admitted to the Neurology Clinic for medicationoveruse headache and associated depression, anxiety and behavioural changes. Treatment consisted in suppressing other drugs and by using an SSRI, citalopram, at modest dosage (≤30 mg daily). Analgesic withdrawal was performed in hospital and was not particularly problematic. Over a 1-year follow-up, pain coping strategies ameliorated and depression decreased; drug withdrawal was easy, even from barbiturates, and pain control was good. Further investigation into the possible use of citalopram or other SSRIs in medication-overuse headache is waranted.

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“…14,120 Within this group of MOH patients, the vast majority first present with episodic migraine or tension-type headache 121 as opposed to other forms of primary headache such as cluster headache. 122 We hypothesise this selective propensity to develop MOH stems from altered pro-inflammatory central immune signalling in patients with migraine and tension-type headache, or the presence of underlying central sensitisation, which renders them particularly susceptible to the effects of opioid-induced glial activation.…”

Section: Pro-inflammatory Central Immune Signalling Hypothesis Of Mohmentioning

confidence: 99%

Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

et al. 2012

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Does Chronic Daily Headache Arise De Novo in Association With Regular Use of Analgesics?

Abstract: These findings suggest that individuals with primary headache, specifically migraine, are predisposed to developing chronic daily headache in association with regular use of analgesics.

Cited by 259 publications

References 46 publications

Preventing chronicity of migraine

Preventing chronicity of migraine

Medication-overuse headache: citalopram associated with analgesics withdrawal as possible treatment

Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

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