2005
DOI: 10.1007/s10194-005-0224-8
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Preventing chronicity of migraine

Abstract: Progression during attacksAllodynia, pain resulting from application of a non-noxious stimulus to normal skin, is a recently described symptom of migraine [3]. In fact clinically detectable allodynia, a manifestation of central sensitisation, occurs with high frequency during migraine attacks. Migraine pain progresses along the neural pathway with throbbing head pain occurring early in the attack (sensitisation of first-order neurons), followed by central sensitisation and cutaneous allodynia within the J Head… Show more

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Cited by 23 publications
(27 citation statements)
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“…This central sensitization could explain the allodynia in migraine, 13 and the extracranial tenderness, in the absence of extracranial pathology 2 . In adults, allodynia serves as a prognostic marker of the progression to chronic and transformed migraine 14 . This practice is based on findings in adults that repeated episodes of central sensitization may exacerbate the disease, and that a longer duration of migraine (in months) and a greater frequency of attacks are significantly correlated with an increase in allodynic symptoms 8 .…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…This central sensitization could explain the allodynia in migraine, 13 and the extracranial tenderness, in the absence of extracranial pathology 2 . In adults, allodynia serves as a prognostic marker of the progression to chronic and transformed migraine 14 . This practice is based on findings in adults that repeated episodes of central sensitization may exacerbate the disease, and that a longer duration of migraine (in months) and a greater frequency of attacks are significantly correlated with an increase in allodynic symptoms 8 .…”
Section: Discussionmentioning
confidence: 96%
“…Regarding the third predictive factor in this study, the early initiation of triptan therapy is currently the best means for achieving rapid, complete, and sustained pain relief from migraines and preventing central sensitization during attacks. Scrupulous management of individual attacks is necessary for an optimal outcome 14 . However, patients with allodynia, a sign of central sensitization, tend to react much less efficiently to triptans.…”
Section: Discussionmentioning
confidence: 99%
“…Stress is often cited as a primary, but not the most important, factor that accelerates progression to headache chronicity. Medication overuse is considered the most important factor, with other related factors including high headache attack frequency, physical trauma, obesity, consumption of caffeine, and female gender 11,31–35 …”
Section: Stress and Headache Disorder Progressionmentioning
confidence: 99%
“…Jasmin et al [2003] suggest that stress affects the pain threshold via changes in γ-aminobutyric acid in the rostral agranular insular cortex. We know that acute stress activates pain inhibition, however, chronic activation could exhaust the system and eventually lead to impairment of inhibition and an increase in the excitability of nociceptive circuitry in patients that experience TTH [Fanciullacci and De Cesaris, 2005;Silberstein and Olesen, 2006]. SSNHL is an unexplained acute hearing loss.…”
Section: Discussionmentioning
confidence: 99%