ONE PLATE (SEVEN FIGURES)Control of the development of form and color in feathers of the domestic fowl has been attained by both genetic and endocrine methods to the extent that certain apparently comparable results may be obtained either by selective breeding or by artificial administration of hormones. Since hereditary factors act on the cells primarily from within, while the hormones are in a sense external, the nature of the interaction between these two agencies becomes a matter of interest. Do the hormones rank on a parity with the genes as determiners of cellular behavior, or are they more nearly comparable to such substances as vitamines or oxygen upon which the tissues have become secondarily dependent? The answer which is found to this question is likely to have a definite influence in shaping an attitude toward problems in both genetics and endocrinology.The results to be reported have a bearing on this question. They are also of interest in relation to the recent work of Lillie and Tuhn ('32), who, with their collaborators, have opened up important new lines of attack. These investigators have studied morphological and color changes in feathers of the brown Leghorn and have found that regional differences in the threshold of response to thyroxin and female hormone are dependent on local differences in the growth rate of the feathers themselves. I n the writer's experience of the past