Does BDNF genotype influence creative output in bipolar I manic patients?

Soeiro-de-Souza, Márcio Gerhardt; Post, Robert M.; Sousa, Mario Lucio de; Missio, Giovani; Prado, Cristiane do; Gattaz, Wagner F.; Moreno, Ricardo Alberto; Machado‐Vieira, Rodrigo

doi:10.1016/j.jad.2012.01.036

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…Above, we discussed polymorphism and epigenetic modulation of COMT. For instance, it has been shown that COMT variants are associated with poor performance on measures of verbal memory in patients with BD when compared to healthy controls (Burdick et al, 2007) or cognitive dysfunction in mania or mixed episodes in patients with BD (Soeiro- de-Souza et al, 2012). Recently, Rybakowski et al (2012) demonstrated that patients with BD are excellent lithium responders and are less prone to have Met/Met genotype.…”

Section: Implications For the Pathophysiology Of Bd And Treatmentmentioning

confidence: 99%

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

Andreazza

Young

2013

Int. J. Neuropsychopharm.

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Bipolar disorder (BD) is a chronic psychiatric illness described by severe changes in mood. Extensive research has been carried out to understand the aetiology and pathophysiology of BD. Several hypotheses have been postulated, including alteration in genetic factors, protein expression, calcium signalling, neuropathological alteration, mitochondrial dysfunction and oxidative stress in BD. In the following paper, we will attempt to integrate these data in a manner which is to understand targets of treatment and how they may be, in particular, relevant to combination treatment. In summary, the data suggested that BD might be associated with neuronal and glial cellular impairment in specific brain areas, including the prefrontal cortex. From molecular and genetics: (1) alterations in dopaminergic system, through catechol-O-aminotransferase; (2) decreased expression and polymorphism on brain-derived neurotrophic factor; (3) alterations cyclic-AMP responsive element binding; (4) dysregulation of calcium signalling, including genome-wide finding for voltage-dependent calcium channel α-1 subunit are relevant findings in BD. Future studies are now necessary to understand how these molecular pathways interact and their connection to the complex clinical manifestations observed in BD.

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Section: Implications For the Pathophysiology Of Bd And Treatmentmentioning

confidence: 99%

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

Andreazza

Young

2013

Int. J. Neuropsychopharm.

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“…The Met allele decreases BDNF transport, contrary to the superior functioning of the BDNF polymorphism (Val(66)Met) Val allele, and has been associated with worsened performance on several cognitive domains in euthymic bipolar-disorder subjects and controls. Manic patients with the Val allele (Met−) had higher Barrow Welsh Art Scale for creativity and neuropsychological test scores than Met+ carriers [191]. …”

Section: Neurotrophic Factorsmentioning

confidence: 99%

Epigenetic Modulation of Mood Disorders

Archer

Blum²,

Ms³

2013

J Genet Syndr Gene Ther

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Background Mood disorders are expressed in many heterogeneous forms, varying from anxiety to severe major clinical depression. The disorders are expressed in individual variety through manifestations governed by co-morbidities, symptom frequency, severity, and duration, and the effects of genes on phenotypes. The underlying etiologies of mood disorders consist of complex interactive operations of genetic and environmental factors. The notion of endophenotypes, which encompasses the markers of several underlying liabilities to the disorders, may facilitate efforts to detect and define, through staging, the genetic risks inherent to the extreme complexity of disease state. Aims This review evaluates the role of genetic biomarkers in assisting clinical diagnosis, identification of risk factors, and treatment of mood disorders. Methods Through a systematic assessment of studies investigating the epigenetic basis for mood disorders, the present review examines the interaction of genes and environment underlying the pathophysiology of these disorders. Results The majority of research findings suggest that the notion of endophenotypes, which encompasses the markers of several underlying liabilities to the disorders, may facilitate efforts to detect and define, through staging, the genetic risks inherent to the extreme complexity of the disease states. Several strategies under development and refinement show the propensity for derivation of essential elements in the etiopathogenesis of the disorders affecting drug-efficacy, drug metabolism, and drug adverse effects, e.g., with regard to selective serotonin reuptake inhibitors. These include: transporter gene expression and genes encoding receptor systems, hypothalamic-pituitary-adrenal axis factors, neurotrophic factors, and inflammatory factors affecting neuroimmune function. Nevertheless, procedural considerations of pharmacogenetics presume the parallel investment of policies and regulations to withstand eventual attempts at misuse, thereby ensuring patient integrity. Conclusions Identification of genetic biomarkers facilitates choice of treatment, prediction of response, and prognosis of outcome over a wide spectrum of symptoms associated with affective states, thereby optimizing clinical practice procedures. Epigenetic regulation of primary brain signaling, e.g., serotonin and hypothalamic-pituitary-adrenal function, and factors governing their metabolism are necessary considerations. The participation of neurotrophic factors remains indispensable for neurogenesis, survival, and functional maintenance of brain systems.

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“…Interestingly, a study found that patients with bipolar disorder in the manic phase only exhibited higher creativity if they had a high-functioning allele in the BDNF gene. In contrast, this effect was not present in patients without mania or healthy controls and is possibly related to an increase in dopaminergic activity [41]. BDNF is involved in neurogenesis, memory and cognition and implicated in depression and bipolar disorder.…”

Section: Creativity Mental Illness and Artmentioning

confidence: 82%

Genes, brain dynamics and art: the genetic underpinnings of creativity in dancing, musicality and visual arts

Sotiropoulos¹,

Anagnostouli²

2021

Journal of Integrative Neuroscience

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Creativity, art and artistic creation in music, dance and visual arts are brain activities specific to humans. Their genetic background remained unexplored for years, but many recent studies have uncovered significant associations with cognition-related genes and loci. These studies are summarized in the present article. Creativity is a trait with heavy genetic influences, which are also associated with mental disorders and altruism. Associated genes include dopaminergic, serotoninergic and other genes (a1-antitrypsin, neuregulin, Brain-derived neurotrophic factor). Music is another complex phenotype with important genetic background. Studies in musicians and their families have highlighted the contribution of loci (e.g., 4q22) and specific genes (vasopressin receptor 1α and serotonin transporter). The latter two are also associated with dancing. Although few studies have investigated visual arts, they appear to be influenced by genetic differences, which could explain the increased prevalence of synesthesia in artists and individuals with autism. Lastly, although genes play an important role in creativity and art, epigenetics and the environment should not be overlooked. The genetic exploration of artistic creativity may provide useful knowledge on cognition, behavior and brain function. It may also enable targeted and personalized art therapy in health and disease.

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Does BDNF genotype influence creative output in bipolar I manic patients?

Cited by 17 publications

References 39 publications

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

Epigenetic Modulation of Mood Disorders

Genes, brain dynamics and art: the genetic underpinnings of creativity in dancing, musicality and visual arts

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