Does aortic valve sclerosis predicts the severity and complexity of coronary artery disease?

Bhatt, Hemal; Sanghani, Dharmesh; Julliard, Kell; Fernaine, George

doi:10.1016/j.ihj.2015.03.010

Cited by 7 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously defined and well-known traditional atherosclerotic risk factors such as advanced age, male sex, HT, DM, and smoking are related to stable CAD rather than ACS, and these risk factors have strong correlations with AVS. In previous studies, it has been demonstrated that AVS and the SS may be related to cardiac mortality and morbidity (2,6,8,9,16,18,19). We also found a strong relation between AVS and the SS and this result supports that AVS is related to the prevalence of CAD and undesired cardiovascular events.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

et al. 2017

View full text Add to dashboard Cite

IntroductionAortic valve sclerosis (AVS) is defined as increased thickness and progressive calcification of aortic valves that causes no obstruction to ventricular output (antegrade velocity across the valve of less than 2.5 m/s) (1). Histopathological studies demonstrated that causes of AVS are the accumulation of atherogenic lipoproteins, inflammatory cell infiltration, and microscopic calcification in the extracellular matrix (2-4). An independent relation was revealed between atherosclerosis risk factors and clinical cardiovascular disease and AVS. This relation implies that AVS and coronary artery disease (CAD) may have a similar mechanism of formation (5).The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) is an angiographic method for grading the complexity and intensity of CAD and provides more comprehen-sive evaluation of properties of the coronary lesion (6-8). Some previous studies showed that a significant correlation between the SS and AVS was revealed in patients with acute coronary syndrome (9). In our study, we investigated the correlation between the SS and AVS by including both ACS and stable CAD cases. Materials and methodsWe enrolled 543 patients with CAD (stable CAD and acute coronary syndrome without ST segment elevation) who underwent coronary angiography in this cross-sectional study between September 2013 and September 2014. The institutional ethics committee approved the study. Patients with persistent ST segment elevation (n = 370), history of percutaneous coronary intervention (n = 190) or coronary artery bypass grafting (n = 77), rheumatic heart valve disease (n = 23), bicuspid aortic valve (n = 14), aortic valvular Background/aim: Aortic valve sclerosis (AVS) is characterized by lipid deposition and calcific infiltration on the edge of aortic leaflets without significant restriction of motion. The SYNTAX Score (SS) is an important method for evaluating coronary artery disease (CAD). Many studies showed that there is an important relation between the SS and undesired cardiac outcomes. In our study, we investigated the correlation between the SS and AVS by including both ACS and stable CAD cases. Materials and methods:We enrolled 543 patients with CAD who underwent coronary angiography into this cross-sectional study between September 2013 and September 2014. Results:The study population was divided into two groups according to SS values above and below 22. Diabetes mellitus (DM) incidence was greater in the group with high SS values (26.3% vs. 19.2%, P = 0.052.). Left ventricular ejection fraction (LVEF) and glomerular filtration rate were lower. Low-density lipoprotein cholesterol and triglyceride levels were lower while platelet counts were higher. In multivariate analysis, for the stable coronary artery group AVS existence, platelet count, LVEF value, and chronic obstructive pulmonary disease were found as independent predictors. Conclusion:Our study results demonstrated that AVS is significantly associated with the complexity o...

show abstract

Section: Discussionsupporting

confidence: 87%

“…Many studies showed that there is an important relation between the SS and undesired cardiac outcomes (8,16,17). To date, there are a few studies investigating the relation between the SS and AVS (2,9,15,18). In these studies, ACS cases were included and the relation of the SS with AVS was investigated.…”

Section: Discussionmentioning

confidence: 99%

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A 2015 study by Bhatt et al 13 attempted to determine the association between the presence or absence of aortic valve sclerosis and cardiovascular risk factors, CAD extent, and severity of coronary lesions. After allocating 482 patients evaluated with coronary cineangiography into two groups, with and without valvular sclerosis, age was the only independent predictor of aortic valve sclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Although Bhatt et al 13 found no association between hypercholesterolemia and mitral annular calcification, further studies are needed to determine whether the use of statins would affect prognosis in these patients. Although many patients in the present study used drugs such as ACEIs (65.5% of the patients), aspirin (45.8%), and statin (17.7%), the study was not delineated to correlate the use of drugs and the presence of cardiac calcification.…”

mentioning

confidence: 91%

See 1 more Smart Citation

Correlation Between Cardiac Calcium Index and Coronary Artery Disease

Sá¹,

Wermelinger²,

Rafael³

et al. 2017

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

ResumoIntroduction: Valvular deposits of calcium quantified by transthoracic echocardiography are associated with the occurrence of systemic atherosclerotic disease, but its prognostic value and influence of associated cardiovascular risk factors have not been defined yet.Objectives: To correlate the valvular cardiac calcium index by transthoracic echocardiography with cardiovascular risk factors and presence of coronary artery disease (CAD). Methods:We selected 203 patients (61.2 ± 14.3 years; 57.6% females) who underwent transthoracic echocardiography with cardiac calcium index quantification. The presence or absence of CAD, hypertension, diabetes mellitus (DM), dyslipidemia, and smoking was assessed.Results: Age above 65 years (p < 0.001) and the presence of hypertension (p < 0.001) showed a significant correlation with the presence of cardiac calcification, whereas DM (p = 0.056) and CAD (p = 0.08) showed only a trend toward a correlation with calcification. Mitral valve calcification alone correlated significantly with age above 65 years (p < 0.001), presence of CAD (p = 0.004), hypertension (p = 0.054), and DM (p = 0.07). On multivariate analysis, CAD (odds ratio [OR] 3.39, 95% confidence interval [95%CI] 1.58-7.29, p = 0.002) and age > 65 years (OR 1.05, 95%CI 1.02-1.08, p = 0.003) correlated significantly and independently with mitral valve calcification. Aortic valve calcification alone showed no correlation with the presence of CAD (p = 0.435), but correlated significantly with age above 65 years (p < 0.001) and hypertension (p < 0.001). On multivariate analysis, only age (OR 1.1, 95%CI 1.06-1.14, p < 0.001) remained independently and significantly correlated with aortic calcification. Conclusion:Age above 65 years and hypertension were independent risk factors for the presence of valvular cardiac calcification, with mitral valve calcification alone emerging as significantly and independently associated with the presence of CAD. (Int J Cardiovasc Sci. 2017;30(2):136-144)

show abstract

Association of Aortic Valve Sclerosis and Clinical Factors in Patients With Acute Myocardial Infarction

Dursun

Kul

Bayraktar

et al. 2019

The American Journal of the Medical Sciences

View full text Add to dashboard Cite

Does aortic valve sclerosis predicts the severity and complexity of coronary artery disease?

Abstract: AVS is probably a benign marker of age-related degenerative changes in the heart independent of the severity and complexity of CAD.

Cited by 7 publications

References 13 publications

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

Aortic valve sclerosis is associated with the extent of coronaryartery disease in stable coronary artery disease

Correlation Between Cardiac Calcium Index and Coronary Artery Disease

Association of Aortic Valve Sclerosis and Clinical Factors in Patients With Acute Myocardial Infarction

Contact Info

Product

Resources

About