Association of Aortic Valve Sclerosis and Clinical Factors in Patients With Acute Myocardial Infarction

Dursun, İhsan; Kul, Selim; Bayraktar, Ali; Erkan, Hakan; Turhan, Turan; Sayın, Muhammet Raşit; Korkmaz, Levent

doi:10.1016/j.amjms.2019.03.007

Cited by 6 publications

(10 citation statements)

References 36 publications

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“…[11] In the study by Dursun et al the authors showed the relationship between CRP levels and the Gensini scores used as indicators of the severity of coronary lesion. [12] Similarly, Luo et al showed that increased CRP values in stable coronary artery disease are associated with all -cause mortality. [13] Similar to the studies investigating the correlation between atherosclerosis and CRP values, in our study, increased CRP values were found to be associated with in-hospital mortality in patients with Covid-19 with a history of CAD.…”

Section: Discussionmentioning

confidence: 96%

Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease

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2021

Journal of Contemporary Medicine

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Introduction: Inflammation plays an important role in the basis of coronary artery diseases and their adverse outcomes. Neutrophillymphocyte ratio (NLR), Systemic Immune Inflammation Index (SII) and C-reactive protein (CRP) are simple and useful markers that reflect the inflammatory state. Our study evaluated the usability of these markers in predicting in-hospital mortality in patients with Covid-19 with the diagnosis of coronary artery disease. Material and Method:Our study population consisted of 111 (48 male, 63 female) newly diagnosed patients with Covid-19. Neutrophil-lymphocyte ratio (NLR) was estimated using neutrophil (N), and lymphocyte (L) counts and the systemic immune inflammation index SII (NxP / L) was calculated using N, L and platelet (P) values. The relationship of NLR, SII and CRP values with in-hospital mortality was investigated.Results: During the treatment process, 16 patients exited. Any statistically significant intergroup difference was not observed as for SII and NLR values obtained by their use in combination (p=0.872, p=0.979, respectively), CRP values were statistically significant in the group with in-hospital mortality (p<0.001). In logistic regression analysis, CRP (odds ratio [OR]=1.078, 95% confidence interval [CI]: 1.0225-1.133, p=0.003) was associated with in-hospital mortality. In ROC analysis, the cut-off values of 3.1 mg / dL, for CRP were significant with 87% sensitivity and 58% specificity in predicting in-hospital mortality (p<0.001).Conclusions: CRP levels are associated with in-hospital mortality in patients with Covid-19 who had also received coronary artery disease with a history of coronary intervention.

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Section: Discussionmentioning

confidence: 96%

Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease

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2021

Journal of Contemporary Medicine

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“…Several studies reported the AVSc prevalence in CAD patients, showing a percentage ranging from 29 to 46% ( 6 , 7 , 17 – 19 ). However, only two studies (for a total of 540 enrolled patients) were focused on high-risk CAD patients (i.e., AMI) with a mean weighted AVSc prevalence of 44% ( 6 , 17 ). In our cohort of almost 5,000 high-risk CAD patients, we have found that AVSc is present in 43% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we confirmed that almost half of the high-risk CAD patients have an abnormal aortic valve with preserved hemodynamic. Regarding the cardiovascular risk factors associated with AVSc, besides age, a recent study performed on 368 AMI patients revealed that only previous AMI was associated with AVSc ( 6 ). Another study focusing on 1,024 AMI patients showed that current smoking was associated with AVSc ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is particularly common in the elderly (2) with studies reporting an estimated prevalence of 25-30% in patients over 65 years and up to 40% in those over 75 years (3)(4)(5). Epidemiological studies suggest that AVSc is associated with both all-cause and cardiovascular mortality, independently of age (5)(6)(7). AVSc shares many underlying mechanisms involved in atherosclerosis, including lipid deposition, oxidative stress, inflammation, and calcification (8).…”

Section: Introductionmentioning

confidence: 99%

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Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients

Myasoedova

Genovese

Cavallotti

et al. 2021

Front. Cardiovasc. Med.

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Background: Current knowledge regarding the relationship between aortic valve sclerosis (AVSc), cardiovascular risk factors, and mortality in patients with known coronary artery disease (CAD) is still unclear. The present study aimed at investigating the prevalence of AVSc as well as its association with long-term all-cause mortality in high-risk CAD patients that has never been explored in large cohorts thus far.Methods and Results: In this retrospective and observational cohort study we enrolled high-risk CAD patients, hospitalized at Centro Cardiologico Monzino (CCM), Milan, Italy, between January 2006 and December 2016. The morphology and function of the aortic valve were assessed from the recorded echocardiographic images to evaluate the presence of AVSc, defined as a non-uniform thickening of the aortic leaflets with no consequences on hemodynamics. Data on 5-year all-cause mortality was retrieved from a Regional database. Of the 5,489 patients initially screened, 4,938 (mean age 67 ± 11 years, 3,954 [80%] men) were enrolled in the study. In the overall population, AVSc was detected in 2,138 (43%) patients. Multivariable LASSO regression revealed that age, female gender, diabetes mellitus, previous MI, and left ventricular ejection fraction were independently associated with AVSc. All-cause mortality (adjusted hazard ratio: 1.29, 95%CI: 1.05–1.58) was significantly higher in AVSc than in non-AVSc patients.Conclusions: AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. Our findings corroborate the hypothesis that AVSc is an underestimated marker of systemic cardiovascular risk. Thus, AVSc detection may be used to improve long-term risk stratification of high-risk CAD patients.

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“…16 In large prospective studies, it has shown that there is a strong and positive relation with AVSc and stroke, coronary artery events, cardiovascular mortality, and other causes of mortality. [15][16][17] In The relationship between PSW and PWD has not been studied prior. Although it is not our goal to show a causal association between them, some mechanisms can be responsible.…”

Section: Discussionmentioning

confidence: 99%

Relation of p ‐ wave dispersion with presystolic a ‐ wave and aortic valve sclerosis in asymptomatic subjects

et al. 2021

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It is well known that prevention is easier than cure. Constantly, scientific and technological developments continue to increase and it enables us new diagnostic and therapeutic methods. Prevention is also important for in the most common cause of persistent arrhythmiaatrial fibrillation (AF), to gain both medical and economic benefits. Studies have shown that atrial fibrillation is underdiagnosed and not adequately treated. Arrhythmia-atrial fibrillation is associated with cardiovascular and thromboembolic events, and higher mortality

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Association of Aortic Valve Sclerosis and Clinical Factors in Patients With Acute Myocardial Infarction

Cited by 6 publications

References 36 publications

Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease

Relationship between in-hospital mortality and inflammation markers in COVID-19 patients with the diagnosis of coronary artery disease

Aortic Valve Sclerosis in High-Risk Coronary Artery Disease Patients

Relation of p ‐ wave dispersion with presystolic a ‐ wave and aortic valve sclerosis in asymptomatic subjects

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