Relation of p ‐ wave dispersion with presystolic a ‐ wave and aortic valve sclerosis in asymptomatic subjects

Akyüz, Ali Rıza; Özderya, Ahmet; Şahin, Sinan; Kul, Selim; Turhan, Turan; Erkan, Hakan; Çırakoğlu, Ömer Faruk; Karal, Hüseyin; Korkmaz, Levent

doi:10.1111/echo.15011

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Our findings are similar to other studies showing that other significant predictors, such as DM, HT and HPL in particular, is also associated with AVS [2,10].…”

Section: Discussionsupporting

confidence: 92%

“…Aortic valve sclerosis (AVS) is defined as the thickening of the aortic valve without a hemodynamically significant obstruction of the left ventricular outflow [1]. Several studies have shown that age, diabetes mellitus (DM), hypertension (HT) and hyperlipidaemia (HPL) are risk factors for AVS [2]. AVS includes multiple pathological similarities to the atherosclerotic process and the prognostic value of AVS is explained by its strong relationship to atherosclerotic risk factors [3,4].…”

Section: Introductionmentioning

confidence: 99%

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The Significance of Novel Hematologic Inflammatory Parameters in Predicting Aortic Valve Sclerosis

Karaaslan

Başyiğit

2022

Archives of Clinical and Experimental Medicine

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Aim: Inflammatory process plays a critical role in the progression of aortic valve sclerosis (AVS). This study aims to evaluate the haematological and biochemical inflammatory markers in AVS patients.Methods: A retrospective observational study was included consecutive 557 patients who underwent an echocardiogram between June 2021 and September 2021. The study population was divided into two groups according to the presence of AVS. The groups were compared in terms of C-reactive protein (CRP), Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-HDL cholesterol ratio (MHR).Results: The mean age was 63 ± 10 years. C-reactive protein (CRP), NLR, PLR and MHR were significantly higher in patients with AVS. The best cut-off values of the NLR were 1.4 (a sensitivity of 84%, a specificity of 74%), PLR was 116 (a sensitivity of 75%, a specificity of 54%), and MHR was 9.5 (a sensitivity of 78%, a specificity of 75%). CRP (OR: 1.246, 95% CI: 1.117 – 1.389; p < 0.001), NLR (OR: 2.10, 95% CI: 1.456 – 3.032; p < 0.001), and MHR (OR: 1.227, 95% CI: 1.125 – 1.339; p < 0.001) were independent predictors of the AVS when NLR and MHR analysed as a continuous variable. Using a cut off level of NLR > 1.4 (OR: 4.825, 95% CI: 2.430 – 9.583; p < 0.001) and MHR > 9.5 (OR: 13.937, 95% CI: 7.464 – 26.023; p < 0.001) were independent predictors of the AVS.Conclusion: Increased CRP levels, NLR and MHR were found to be independent predictors for AVS. Hematological inflammatory biomarkers are cost effective and helpful approach for prediction of AVS presence.

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“…Our findings are similar to other studies showing that other significant predictors, such as DM, HT and HPL in particular, is also associated with AVS [2,10].…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Significance of Novel Hematologic Inflammatory Parameters in Predicting Aortic Valve Sclerosis

Karaaslan

Başyiğit

2022

Archives of Clinical and Experimental Medicine

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“…The clinical consequences of having a presystolic wave are studied by Joshi et al [1], who found that in patients with low EF, the absence of the wave was associated with higher major adverse cardiac effects. The only study to evaluate the direct relationship between systemic hypertension and presystolic wave is conducted by Akyüz et al, [19] which showed a positive relationship in office blood pressure measurements. Our findings were consistent with previous studies in terms of associations of age, mitral inflow a wave and LVH.…”

Section: Discussionmentioning

confidence: 99%

The relationship of left ventricular outflow tract presystolic wave and 24-h ambulatory blood pressure measurements

Demiröz

Öztürkeri

2022

Blood Pressure Monitoring

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Objective Left ventricular outflow tract (LVOT) presystolic wave is a novel marker for several cardiac conditions. It is shown to be related to several cardiac conditions. The aim of this study is to investigate the relationship between LVOT presystolic wave and 24-h ambulatory blood pressure measurements.Methods A total of 194 patients who came to the cardiology outpatient clinic were prospectively enrolled in the study. After demographic and clinical inquiry, blood biochemistry and hemogram tests were performed. Each patient was evaluated with echocardiography and 24-h ambulatory blood pressure measurement. The patients were divided into hypertensive and nonhypertensive groups regarding their ambulatory blood pressure measurements and the LVOT presystolic wave of the groups on echocardiography was compared. ResultsThe hypertensive group was significantly older (59.34 ± 11.15 vs. 49.89 ± 15.43; P < 0.001). Presystolic wave presence (96.2 vs. 29.5%; P < 0.001) and velocity (62.23 vs. 29.42; P < 0.001) were higher in patients with hypertension. Blood pressure values and LVOT amplitudes showed a positive correlation (P < 0.001; r = 0.326). In multivariable logistic regression analysis; age, BMI and the presystolic wave were independently associated with hypertension (odds ratio: 8.09; P < 0.001). ConclusionLVOT presystolic wave is associated with systemic hypertension and it could be used as a predictor for systemic hypertensive patients.

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Relation of p ‐ wave dispersion with presystolic a ‐ wave and aortic valve sclerosis in asymptomatic subjects

Cited by 2 publications

References 24 publications

The Significance of Novel Hematologic Inflammatory Parameters in Predicting Aortic Valve Sclerosis

The Significance of Novel Hematologic Inflammatory Parameters in Predicting Aortic Valve Sclerosis

The relationship of left ventricular outflow tract presystolic wave and 24-h ambulatory blood pressure measurements

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