Does anodal transcranial direct current stimulation enhance excitability of the motor cortex and motor function in healthy individuals and subjects with stroke: A systematic review and meta-analysis

Bastani, Andisheh; Jaberzadeh, Shapour

doi:10.1016/j.clinph.2011.08.029

Cited by 210 publications

(173 citation statements)

References 53 publications

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“…Adeyemo et al (2012) demonstrated a significant effect size (0.58) of non-invasive brain stimulation on motor function. Bastani and Jaberzadeh, 2012 showed that anodal tDCS had a small non-significant effect size of 0.39 on hand function in stroke, but a moderate significant effect size of 0.59 on motor evoked potential amplitude. Butler et al (2013) also demonstrated a significant small effect size of 0.40 of anodal tDCS on UE motor recovery.…”

Section: Introductionmentioning

confidence: 96%

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Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Triccas

Burridge

Hughes

et al. 2016

Clinical Neurophysiology

101

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h i g h l i g h t stDCS and rehabilitation had small non-significant effect on upper extremity impairments. Varied tDCS and rehabilitation programmes were identified in selected studies. Future research needs to further analyse tDCS and therapy interventions in stroke. a b s t r a c tObjective: To systematically review the methodology in particular treatment options and outcomes and the effect of multiple sessions of transcranial direct current stimulation (tDCS) with rehabilitation programmes for upper extremity recovery post stroke. Methods: A search was conducted for randomised controlled trials involving tDCS and rehabilitation for the upper extremity in stroke. Quality of included studies was analysed using the Modified Downs and Black form. The extent of, and effect of variation in treatment parameters such as anodal, cathodal and bi-hemispheric tDCS on upper extremity outcome measures of impairment and activity were analysed using meta-analysis. Results: Nine studies (371 participants with acute, sub-acute and chronic stroke) were included. Different methodologies of tDCS and upper extremity intervention, outcome measures and timing of assessments were identified. Real tDCS combined with rehabilitation had a small non-significant effect of +0.11 (p = 0.44) and +0.24 (p = 0.11) on upper extremity impairments and activities at post-intervention respectively. Conclusion: Various tDCS methods have been used in stroke rehabilitation. The evidence so far is not statistically significant, but is suggestive of, at best, a small beneficial effect on upper extremity impairment. Significance: Future research should focus on which patients and rehabilitation programmes are likely to respond to different tDCS regimes.

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Section: Introductionmentioning

confidence: 96%

“…Recent meta-analyses have explored the effect of tDCS in addition to rehabilitation on UE activity in stroke (Bastani and Jaberzadeh, 2012;Adeyemo et al, 2012;Butler et al, 2013;Elsner et al, 2013). Adeyemo et al (2012) demonstrated a significant effect size (0.58) of non-invasive brain stimulation on motor function.…”

Section: Introductionmentioning

confidence: 99%

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Triccas

Burridge

Hughes

et al. 2016

Clinical Neurophysiology

101

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“…As Tthese stimulation parameters have been shown to influence the efficacy of anodal tDCS (Bastani and Jaberzadeh, 2012),. Thus, there is clearly a need for systematically determining the optimal parameters to maximize the beneficial effects of anodal tDCS.…”

Section: Limitationsmentioning

confidence: 99%

Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta- analysis

Summers

Kang

Cauraugh

2016

Ageing Research Reviews

155

121

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The use of transcranial direct current stimulation (tDCS) to enhance cognitive and motor functions has enjoyed a massive increase in popularity. Modifying neuroplasticity via non-invasive cortical stimulation has enormous potential to slow or even reverse declines in functions associated with ageing. The current meta-analysis evaluated the effects of tDCS on cognitive and motor performance in healthy older adults. Of the 81 studies identified, 25 qualified for inclusion. A random effects model meta-analysis revealed a significant overall standardized mean difference equal to 0.53 (SE = 0.09; medium heterogeneity: I 2 = 57.08%; and high fail-safe: N = 448). Five analyses on moderator variables indicated significant tDCS beneficial effects: (a) on both cognitive and motor task performances, (b) across a wide-range of cognitive tasks, (c) on specific brain areas, (d) stimulation offline (before) or online (during) the cognitive and motor tasks. Although the meta-analysis revealed robust support for enhancing both cognitive and motor performance, we outline a number of caveats on the use of tDCS.

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“…These two electrodes, cathode and anode, allow for two separate types of stimulation, which have been shown to yield opposite results. Anodal stimulation causes depolarization and increases in excitement, while cathodal stimulation causes hyperpolarization and a decrease in excitement (3,32). These changes in excitement are not great enough to cause direct firing, but rather manipulate the potential nearer or further from threshold (12).…”

mentioning

confidence: 99%

“…Because of the neuromodulatory effect, plasticity changes, and increased CBF incurred through tDCS (6,7), this method has been used to decrease the effects of neurological (17) or psychological disorders (2) as well as delaying the onset of fatigue (42). Effects of tDCS are dependent upon frequency and time of stimulation as well as intensity of current (3,53).…”

mentioning

confidence: 99%

The Effects of Transcranial Direct Current Stimulation (tDCS) on Fatigue During Maximal Intensity Exercise

Deckert

Herda

Gallagher

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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Does anodal transcranial direct current stimulation enhance excitability of the motor cortex and motor function in healthy individuals and subjects with stroke: A systematic review and meta-analysis

Cited by 210 publications

References 53 publications

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta- analysis

The Effects of Transcranial Direct Current Stimulation (tDCS) on Fatigue During Maximal Intensity Exercise

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