Does angina pectoris the week before protect against first acute myocardial infarction in patients with diabetes mellitus?

Jiménez-Navarro, Manuel F.; Gómez‐Doblas, Juan José; Garcı́a, José Marı́a Hernández; Alonso‐Briales, Juan H.; Alcántara, A. García; Gómez, Gemma Cardona; Rodríguez–Bailón, Isabel; Teresa, Eduardo de

doi:10.1016/s0002-9149(02)02442-6

Cited by 9 publications

(15 citation statements)

References 12 publications

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“…This protective effect has been seen in older and in diabetic patients 3,4,5 but there is little and often controversial information available about long-term prognosis. In the present study preinfarction angina was not associated with a lower incidence of cardiovascular complications after initial hospitalization in these subgroups of patients.…”

Section: Discussionmentioning

confidence: 99%

“…The inclusion criteria and in-hospital complications have been described previously. 3,4 We chose the first MI as an inclusion criterion to avoid confounding bias in patients with a previous history of ischemic pain. Further inclusion criteria were no history of angina for more than 1 week before their first MI, and no evidence of prior structural cardiopathy.…”

Section: Methodsmentioning

confidence: 99%

“…Previously preinfarction angina has been associated with a lower incidence of in-hospital complications, 1,2 especially in older people 3 and diabetic patients. 4,5 Several studies suggest that patients with preinfarction angina have smaller infarcts and a better prognosis than those without angina.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Several studies suggest that patients with preinfarction angina have smaller infarcts and a better prognosis than those without angina. Several mechanisms, including ischemic preconditioning, have been proposed to explain these benefits.…”

Section: Introductionmentioning

confidence: 99%

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Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients

Muñoz-García

Ramírez-Marrero

Domínguez-Franco

et al. 2009

Clinical Cardiology

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Background and hypothesis:Although prodromal angina occurring shortly before an acute myocardial infarction (MI) has protective effects against in-hospital complications, this effect has not been well documented after initial hospitalization, especially in older or diabetic patients. We examined whether angina 1 week before a first MI provides protection in these patients. Methods: A total of 290 consecutive patients, 143 elderly (>64 years of age) and 147 adults (<65 years of age), 68 of whom were diabetic (23.4%) and 222 nondiabetic (76.6%), were examined to assess the effect of preceding angina on long-term prognosis (56 months) after initial hospitalization for a first MI. Results: No significant differences were found in long-term complications after initial hospitalization in these adult and elderly patients according to whether or not they had prodromal angina (44.4% with angina vs 45.4% without in adults; 45.5% vs 58% in elderly, P<0.2). Nor were differences found according to their diabetic status (61.5% with angina vs 72.7% without in diabetics; 37.3% vs 38.3% in nondiabetics; P = 0.4).

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients

Muñoz-García

Ramírez-Marrero

Domínguez-Franco

et al. 2009

Clinical Cardiology

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“…On the other hand, Kloner et al 24 conducted a retrospective study of the patients of the TIMI-4 study and found that elderly patients with PIA had lower rates of the combined endpoints of death, CHF/cardiogenic shock and/or reinfarction, compared with those without PIA 24 . Jimenez-Navarro et al 25 found that PIA protected against inhospital adverse outcomes and preserved LV function in older patients 25 . Kosuge et al 26 reported that PIA was associated with smaller myocardial infarct size and better in-hospital survival in both elderly and non-elderly patients 26 .…”

Section: Discussionmentioning

confidence: 99%

Angina pré-infarto na evolução intra-hospitalar de pacientes idosos com infarto agudo do miocárdio

Shian

Lima

Filho

2007

Arq. Bras. Cardiol.

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Protection in the aged heart: preventing the heart-break of old age?

Juhaszova

Rabuel

Zorov

et al. 2005

Cardiovascular Research

131

106

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The aged heart has a diminished functional and adaptive reserve capacity, an increased susceptibility to incur damage (e.g., as a result of ischemia), and a limited practical ability for repair/regeneration. Thus, there has been considerable interest to harness the heart's endogenous capacity to resist such damage, known as ischemic preconditioning (IPC), as well as other cardioprotective mechanisms. However, the translation of basic research findings into clinical practice has largely been inadequate because there have been few if any successful implementations in terms of viable therapies activating cardioprotection mechanisms to limit infarct size. Here, we provide an overview of the general mechanisms of cardioprotection, changes in the structure and function of the aged heart, and the current knowledge regarding cardioprotection in aged heart. The problems and opportunities for successful bench-to-bedside translation of cardioprotection in the elderly are discussed.

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Does angina pectoris the week before protect against first acute myocardial infarction in patients with diabetes mellitus?

Cited by 9 publications

References 12 publications

Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients

Preinfarction Angina Prior to First Myocardial Infarction Does not Influence Long‐Term Prognosis: A Retrospective Study with Subgroup Analysis in Elderly and Diabetic Patients

Angina pré-infarto na evolução intra-hospitalar de pacientes idosos com infarto agudo do miocárdio

Protection in the aged heart: preventing the heart-break of old age?

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