Does advanced maternal age affect pregnancy outcome in women with mild hypertension remote from term?

Bergauer, Niki K.; Jacques, Debbie; Coleman, Suzanne; Stanziano, Gary; Sibai, Baha M.

doi:10.1016/s0002-9378(97)70340-5

Cited by 32 publications

(23 citation statements)

References 14 publications

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“…They found 2 times greater risk of preeclampsia in advanced age pregnancies [4,18]. Bobrowski and Bottoms, Bianco et al and Barton et al also find three times increased risk of preeclampsia in advanced age pregnancies [1,6,19]. In agreement with these reports we find increased risk of developing preeclampsia in the advanced age pregnancies.…”

Section: Resultssupporting

confidence: 91%

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Perinatal Outcomes in Advanced Age Pregnancies

Yılmaz¹,

Tosun²,

Tarhan³

et al. 2016

J Clin Exp Invest

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Objective: The aim of this study is to evaluate the impact of advanced maternal age on pregnancy outcomesMethods: A retrospective analysis of 951 birth registry records of Zeynep Kamil Hospital, were analyzed between January 2003 and December 2007. Study group was made up of women ≥40 years old and control group was made up of women younger than 40 years.Results: Mean maternal age was 41.48 years in the study group and 26.41 years in the control group. Mean gestational age at the time of delivery is 37.73 weeks in study group and 38.10 weeks in the control group. There was no statistical difference in terms of preterm delivery, multiple pregnancy, fetal anomaly, IUGR, superimpose preeclampsia oligohidramnios, presentation anomaly and placenta previa rates between the study and control groups. Incidence of preeclampsia (p=0.041), Chronic hypertension (p=0.001), GDM (p= 0.003),is found to be higher in study group. Cesarean birth rate is higher (p<0.05) and hospitalization time is longer in study group (p=0.001). 1 st minute and 5 th minute APGAR scores of the study group (6.99±2, 8.27±2) was lower than the 1 st minute and 5 th Minutes APGAR scores of the control group (7.38±1.6, 8.58±1.7). Neonatal intensive care unit administration rate is seen also higher in study group (p<0.01). Conclusion:Advanced maternal age was related to increased pregnancy complications and poor perinatal outcome. Preeclampsia, GDM, chronic hypertension is seen more common in advanced age pregnancies. Neonatal intensive care administration is higher and APGAR scores are lower; cesarean delivery was performed more common, and hospitalization time was longer in advanced age pregnancies. Bulgular: Ortalama anne yaşı Çalışma grubunda 41,48 kontrol gurubunda 26,41'dir. Doğumda ortalama gebelik haftası çalışma gurubunda 37,73 kontrol grubunda 28,10'dur Çalışma ve kontrol grupları arasında Preterm doğum, çoğul gebelik, fetal anomali, intrauterin gelişme geriliği, süperimpoze preeklampsi, oligohidramniyos, prezentasyon anomalisi ve plasenta previa oranları arasında istatistiksel anlamlı fark saptanmadı. Çalışma grubunda preeklampsi, kronik hipertansiyon, gestasyonel diyabet, insidansı kontrol grubundan istatistiksel olarak anlamlı olarak yüksek saptandı (p=0,041, p=0,001, p=0,003). Sezaryen doğum oranı, hastanede kalış süresi çalışma grubunda anlamlı olarak yüksek bulundu (p<0,05, p=0,001).Çalışma grubunda yenidoğan 1. ve 5. Dakika APGAR skorları kontrol grubundan düşük saptandı (p<0,01). Çalışma grubunda yenidoğan yoğun bakım ünitesine yatış oranı istatistiksel olarak anlamlı derece yüksek saptandı (p<0,01). Sonuç:İleri anne yaşı yüksek gebelik komplikasyonları ve kötü perinatal sonuçlarla ilişkilidir. Preeklampsi, Gestasyonel Diyabet, kronik hipertansiyon ileri anne yaşı gebeliklerinde daha sık görülmektedir. İleri anne yası gebeliklerinde Yenidoğan yoğun bakım yatış oranı daha yüksek, APGAR skorları daha düşük, sezaryen doğum oranı daha yüksek hastanede kalış daha uzundur.Anahtar kelimeler: Perinatal sonuçlar, ileri anne yaş gebelikle...

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Section: Resultssupporting

confidence: 91%

“…Many studies have demonstrated an increased risk of preeclampsia in advanced age pregnancies [1,4,6,8,12,[17][18][19]. Prysak et al 1995 reported the incidence of preeclampsia at 25-29 age pregnancies %3 in multiparous and 7% in nulliparous.…”

Section: Resultsmentioning

confidence: 99%

Perinatal Outcomes in Advanced Age Pregnancies

Yılmaz¹,

Tosun²,

Tarhan³

et al. 2016

J Clin Exp Invest

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“…Traditionally, these women are believed to have more adverse pregnancy outcomes than younger pregnant women do [11]. This study is one of the larger ones to assess many different potential complications in older nulliparous women.…”

Section: Discussionmentioning

confidence: 99%

Maternal and Perinatal Outcome in Nulliparous Women Aged 35 and Older

Ziadeh¹

2002

Gynecol Obstet Invest

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Objective: To compare the maternal and perinatal outcome of nulliparous women 35 years and older at the time of delivery with nulliparous women 25–29 years old. Methods: A retrospective review of maternal and newborn records of singleton gestations only for first birth in women aged 35 and older (study group n = 143) were compared with pregnancies of women aged 25–29 (control group, n = 148) delivered at the same period with respect to pregnancy complications and outcome. The study was performed at the Princess Badeea Teaching Hospital in North Jordan between January 1, 1996 and July 1, 2000. Results: Most of the elderly nulliparous women were professionals (60%) and 20% had a history of infertility. Compared with women aged 20–29 years, women delivering their first child at or >35 years were at increased risk of weight gain, obesity, chronic and pregnancy-induced hypertension, antepartum haemorrhage, multiple gestation, malpresentation, and premature rupture of membranes. Women aged 35 years and older were also substantially more likely to have preterm labour, oxytocin use, and caesarean births. The older women differed significantly in neonatal outcomes: gestational age, birth weight, preterm delivery, low birth weight, small for gestational age, fetal distress and neonatal intensive care unit admissions. Conclusion: It is concluded that nulliparous women 35 years and older had higher risk of antepartum, intrapartum, and neonatal complications than nulliparous women aged 25–29 years, but these risks, for the most part, are manageable in the context of modern obstetrics. The excess rate of caesarean sections is only partially accounted for by gestational complications. Despite the increased risk of complications, perinatal death of the study group was similar to that of the control group. There were no maternal deaths.

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“…Generally, the identifi cation of potential factors associated with PE in a given population requires a great effort. Previously described risk factors for PE include socio-demographical factors (extremes of reproductive age, socio-economic status, ethnic group), genetic factors, pregnancy factors (multiple pregnancies, primigravidae, previous preeclampsia) or personal medical history (obesity, chronic renal disease, chronic hypertension, diabetes mellitus, thrombophilia) [3][4][5][6][7] . Several authors associate PE with obesity during pregnancy.…”

mentioning

confidence: 99%

“…Eating habits are closely connected with excessive weight gain during pregnancy. Hypercaloric food, especially high in carbohydrate and fat, and low in proteins could cause a metabolic misbalance leading to PE 6,8,9 . While some authors consider that there is a connection between PE and smoking, others disagree 10 .…”

mentioning

confidence: 99%