Doenças cardiovasculares observadas durante o seguimento de um grupo de pacientes na forma indeterminada da doença de Chagas

Ianni, Bárbara Maria; Mady, Charles; Arteaga, Edmundo; Fernandes, Fábio

doi:10.1590/s0066-782x1998000700005

Cited by 21 publications

(9 citation statements)

References 10 publications

(7 reference statements)

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“…Regarding comorbidities, the percentage of SAH, DM, and dyslipidemia in this cohort is similar to the estimated prevalence of these comorbidities in the Brazilian population, and, as described in other series of patients with CD, none of them were associated with ECG progression [36,37]. Some studies demonstrated no risk in the coexistence of SAH and CD [38]. In our cohort, 16 patients (2.9%) had associated heart disease at baseline, most often LVH, with minimal or no degree of LV systolic dysfunction.…”

Section: Discussionsupporting

confidence: 86%

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Hasslocher‐Moreno¹,

Xavier²,

Saraiva³

et al. 2020

TropicalMed

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Most patients with chronic Chagas disease (CD) present the indeterminate form and are at risk to develop the cardiac form. However, the actual rate of progression to the cardiac form is still unknown. Methods: In total, 550 patients with the indeterminate CD form were followed by means of annual electrocardiogram at our outpatient clinic. The studied endpoint was progression to cardiac form defined by the appearance of electrocardiographic changes typical of CD. The progression rate was calculated as the cumulative progression rate and the incidence progression rate per 100 patient years. Results: Thirty-seven patients progressed to the CD cardiac form within a mean of 73 ± 48 months of follow-up, which resulted in a 6.9% cumulative progression rate and incidence rate of 1.48 cases/100 patient years. Patients who progressed were older (mean age 47.8 ± 12.2 years), had a higher prevalence of associated heart diseases (p < 0.0001), positive xenodiagnosis (p = 0.007), and were born in the most endemic Brazilian states (p = 0.018). Previous co-morbidities remained the only variable associated with CD progression after multivariate Cox proportional hazards regression analysis (p = 0.002). Conclusion: The progression rate to chronic CD cardiac form is low and inferior to rates previously reported in other studies.

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Section: Discussionsupporting

confidence: 86%

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Hasslocher‐Moreno¹,

Xavier²,

Saraiva³

et al. 2020

TropicalMed

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“…Previous publications have shown that SAH is the most common cardiovascular disease in chagasic populations 3 , 27 , 46 , 57 and that it has a higher prevalence in patients aged over 50 years, showing a cumulative effect between the two pathologies 5 , 24 . Greater myocardial damage was observed by GUARIENTO et al 20 in patients with this combination of diseases.…”

Section: Discussionmentioning

confidence: 95%

Clinical and Epidemiological Profile of Elderly Patients With Chagas Disease Followed Between 2005-2013 by Pharmaceutical Care Service in Ceará State, Northeastern Brazil

Pereira

Freitas

Fidalgo

et al. 2015

Rev. Inst. Med. trop. S. Paulo

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By controlling the transmission of Chagas disease, the challenge of providing assistance to millions of infected patients that reach old age arises. In this study, the socioeconomic, demographic and comorbidity records of all elderly chagasic patients followed at the Pharmaceutical Care Service of the Chagas Disease Research Laboratory were assessed. The information related to the clinical form of the disease was obtained from medical records provided by the Walter Cantídio University Hospital. The profile of the studied population was: women (50.5%); mean age of 67 years; retired (54.6%); married (51.6 %); high illiteracy rate (40.2%); and family income equal to the minimum wage (51.5%). The predominant clinical forms of Chagas disease were cardiac (65.3%) and indeterminate (14.7%). The main electrocardiographic changes were the right bundle branch block (41.0%), associated or not with the anterosuperior left bundle branch block (27.4%). The average number of comorbidities per patient was 2.23 ± 1.54, with systemic arterial hypertension being the main one found (67.0%). It was found that the elderly comprise a vulnerable group of patients that associate aging with cardiac and/or digestive disorders resulting from the evolution of Chagas disease and other comorbidities, which requires special attention from health services to ensure more appropriate medical and social care.

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“…Its contribution to patient outcome as a risk factor for Chagas heart disease was therefore assessed. Previous publications have shown that systemic hypertension is the most frequently present cardiovascular condition among Chagas patients (Ianni et al 1998), and that its prevalence is greater in patients with age ≥ 50, supporting the existence of an additive character between both illnesses (Guariento et al 1993). This study showed that the presence of this comorbidity factor is not linked to development of Chagas heart disease and does not produce a confusion factor.…”

Section: Discussionmentioning

confidence: 88%

Case-control study of factors associated with chronic Chagas heart disease in patients over 50 years of age

Silva

Gontijo

Amaral

2007

Mem. Inst. Oswaldo Cruz

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Doenças cardiovasculares observadas durante o seguimento de um grupo de pacientes na forma indeterminada da doença de Chagas

Cited by 21 publications

References 10 publications

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Progression Rate from the Indeterminate Form to the Cardiac Form in Patients with Chronic Chagas Disease: Twenty-Two-Year Follow-Up in a Brazilian Urban Cohort

Clinical and Epidemiological Profile of Elderly Patients With Chagas Disease Followed Between 2005-2013 by Pharmaceutical Care Service in Ceará State, Northeastern Brazil

Case-control study of factors associated with chronic Chagas heart disease in patients over 50 years of age

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