Doehlert experimental design applied to optimization of light emitting textile structures

Oguz, Yesim; Cochrane, Cédric; Končar, Vladan; Mordon, Serge

doi:10.1016/j.yofte.2016.01.012

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…Woven fabrics consist of two interconnected orthogonal thread systems of warp and weft yarns. Thus, OFs can easily be integrated as a warp or weft yarn [60][61][62][63] or as an embroidery pattern [64][65][66], providing an emission perpendicular to the plane of the fabric on both sides of the surface, as shown in Figure 1. Knitted fabrics are made up of intertwined loops.…”

Section: Light-emitting Fabric-based Technologiesmentioning

confidence: 99%

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A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

Thecua

Ziane

Grolez

et al. 2021

Cancers

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Photodynamic therapy (PDT) appears to be a promising strategy in biomedical applications. However, the complexity of its parameters prevents wide acceptance. This work presents and characterizes a novel optical device based on knitted light-emitting fabrics and dedicated to in vitro PDT involving low irradiance over a long illumination period. Technical characterization of this device, called CELL-LEF, is performed. A cytotoxic study of 5-ALA-mediated PDT on human cancer cell lines is provided as a proof of concept. The target of delivering an irradiance of 1 mW/cm2 over 750 cm2 is achieved (mean: 0.99 mW/cm2; standard deviation: 0.13 mW/cm2). The device can maintain a stable temperature with the mean thermal distribution of 35.1 °C (min: 30.7 °C; max: 38.4 °C). In vitro outcomes show that 5-ALA PDT using CELL-LEF consistently and effectively induced a decrease in tumor cell viability: Almost all the HepG2 cells died after 80 min of illumination, while less than 60% of U87 cell viability remained. CELL-LEF is suitable for in vitro PDT involving low irradiance over a long illumination period.

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Section: Light-emitting Fabric-based Technologiesmentioning

confidence: 99%

“…Regardless of the textile structure, poly(methyl methacrylate) (PMMA) optical fibers are usually employed to limit the risk of breakage during the manufacturing process [59]. Optimization of light distribution remains a challenge and relies on the perfect control of bending angles and radii [62]. 2.2.2.…”

Section: Light-emitting Fabric-based Technologiesmentioning

confidence: 99%

A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

Thecua

Ziane

Grolez

et al. 2021

Cancers

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“…By integration of plastic optical fibers within knitted or woven structure, light emission can be obtained over flexible textile surfaces. Homogeneity of spatial light distribution can be obtained under the condition of controlling the density of the fibers and the angles and radii of curvature [8].…”

Section: Principle Of Lefmentioning

confidence: 99%

Light emitting fabrics for photodynamic therapy: Technology, experimental and clinical applications

Mordon

Thecua

Ziane

et al. 2020

Transl Biophotonics

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A homogeneous and reproducible fluence rate delivery during clinical photodynamic therapy (PDT) plays a determinant role in preventing under-or overtreatment. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical fibers into textile structures offers an interesting alternative. This article aims to describe briefly the technology used to develop light emitting fabrics (LEF) and their use in vitro (CELL-LEF), in vivo (VIVO-LEF) for experimental evaluation of PDT. Finally, the use of LEF for clinical applications is given by three examples. For in vitro applications, the CELL-LEF device allows the illumination of several 96-well cell culture plates. For the VIVO-LEF, the system developed for PDT can treat three mice simultaneously with a homogeneous and high irradiance The medical LEF systems developed for PDT in dermatology for the treatment of actinic keratosis demonstrate their superiority thanks to a uniform light distribution due the flexibility of LEF. Interestingly, the technology used for manufacturing LEF is very well known by the textile industry, leading to very competitive production costs. The fact that optical fibers can transmit light from 400 to 1200 nm allows the connection of LEF to different laser sources covering the light spectrum of all photosensitizers used for medical applications. New developments should allow to use the LEF inside cavities such as the pleural or the peritoneal cavities.

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“…However, it was also important to optimize the light intensity (mW.cm -2 ) for a successful PDT. To improve the lateral light intensity and obtain an LEF that emits a consistent and powerful light at the same time, tension is added on the warp yarns during weaving [39]. Thanks to the added tension during weaving, it was possible to modify the curvatures of the optical fibers inserted into the LEF.…”

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

Light-Emitting Woven Fabric for Treatment with Photodynamic Therapy and Monitoring of Actinic Keratosis

Oguz¹,

Končar²,

Cochrane³

et al. 2017

Photomedicine - Advances in Clinical Practice

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A successful photodynamic therapy (PDT) requires a specific photosensitizer, oxygen and light of a specific wavelength and power. Today photodynamic therapy (PDT) is administered to patients with light-emitting diode (LED) panels. These panels deliver a non-uniform light distribution on the human body parts, as the complex human anatomy is not a flat surface (head vertex, hand, shoulder, etc.). For an efficient photodynamic therapy (PDT), a light-emitting fabric (LEF) was woven from plastic optical fibers (POF) aiming at the treatment of dermatologic diseases such as actinic keratosis (AK). Plastic optical fibers (POF) (Toray, PGR-FB250) have been woven in textile in order to create macro-bendings, and thus emit out the injected light directly to the skin. The light intensity and light-emitting homogeneity of the LEF were improved thanks to Doehlert Experimental Design. During the treatment with PDT, the photosensitizers were activated in the cancerous cells. These cells may be visualized, as they show a characteristic fluorescence under UV light, which is called fluorescence diagnosis (FD). Therefore, it is proposed to modify the developed LEF for PDT to measure the fluorescence amount. For this aim, a part of POFs was cut out to observe the quantity of light that could be collected while the LEF was connected to a light source. The first prototypes showed the possibility of the illumination with the same LEF without losing the efficiency but also imaging the collected light.

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Doehlert experimental design applied to optimization of light emitting textile structures

Cited by 12 publications

References 28 publications

A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

Light emitting fabrics for photodynamic therapy: Technology, experimental and clinical applications

Light-Emitting Woven Fabric for Treatment with Photodynamic Therapy and Monitoring of Actinic Keratosis

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