Doehlert design-desirability function multi-criteria optimal separation of 17 phenolic compounds from extra-virgin olive oil by capillary zone electrophoresis

Ballus, Cristiano Augusto; Meinhart, Adriana Dillenburg; Campos, Francisco Alberto de Souza; Bruns, Roy E.; Godoy, Helena Teixeira

doi:10.1016/j.foodchem.2013.09.102

Cited by 28 publications

(9 citation statements)

References 32 publications

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“…Dias et al (2015), employed models with values of F calculated up to 10 times higher than the values of F critical , obtaining satisfactory results in the optimization of responses. Similarly, in Meinhart et al (2011) and Ballus et al (2014) studies, models with a slight lack of fit significantly contributed to the optimization of the analysis methods. Considering that such models presented random residual distribution, these were kept in the process of simultaneous optimization of responses.…”

Section: Methods Optimization and Experimental Designmentioning

confidence: 99%

Development of a method for simultaneous analysis of caffeine and taurine in energy drinks by micellar electrokinetic chromatography with diode-array detector

et al. 2019

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The objective of this study was to develop, optimize and validate a fast and reliable method for the simultaneous determination of caffeine and taurine contents by micellar electrokinetic chromatography with diode array detector, using direct and indirect detection concomitantly. Multivariate statistical techniques were used as a central composite design and the simultaneous optimization method of responses of Derringer and Suich were used for optimization. The method was applied in the analysis of 73 samples of energy drinks commercialized in Brazil. The optimized method employed a capillary tube with an extended bulb of 50 µm i.d. x 72 cm total length, an electrolyte containing 16.20 mmol.L-1 of benzoic acid and 39.90 mmol.L-1 of SDS, a pH value of 7.26, + 30 kV voltage, direct detection of caffeine at 274 nm and indirect detection of taurine at 230 nm. Validation parameters have demonstrated the reliability and applicability of this method. Ot was found that more than 50% of the samples were out of the legal limits determined by the Brazilian government regarding the taurine content and 68 % contained caffeine below the value declared on the label. Therefore, the need for greater control concerning the composition of these drinks exists.

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Section: Methods Optimization and Experimental Designmentioning

confidence: 99%

Development of a method for simultaneous analysis of caffeine and taurine in energy drinks by micellar electrokinetic chromatography with diode-array detector

et al. 2019

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“…The models with F calculated values up to 10 times the F critical value were accepted. Some authors cited this procedure as a useful tool to avoid loss of experimental data, although it may introduce some prediction errors (Ballus et al 2014). Thus, nine models (Sac-Cyc 192 nm, Sac-Cyc 201 nm, I1-Sac, I2-Sac, I5-Sac, Sac-I5, Ace-I5, Ace-I1 and I1-Ace) were included in the simultaneous optimisation process.…”

Section: Multivariate Studymentioning

confidence: 99%

Multivariate Optimisation and Validation of a Method for the Separation of Five Artificial Sweeteners by UPLC-DAD in Nine Food Matrices

Dias¹,

Meinhart

Pane

et al. 2014

Food Anal. Methods

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A new, fast and efficient method was developed for the separation and simultaneous quantification of acesulfame-K, aspartame, cyclamate, neotame and saccharin in food by ultraperformance liquid chromatography (UPLC) and diode array detector (DAD). Univariate strategies were applied for the optimisation of mobile phase pH, proportion of solvents in the mobile phase, flow rate and column temperature. Multivariate techniques were used for the simultaneous optimisation of 13 responses applying the Derringer and Suich desirability function. Many of the models presented lack of fit. However, it was possible to optimise the method using strategies for the restriction of the region to be investigated by the algorithm used in the desirability function. The optimised method was validated and applied to nine food matrices (soft drink, nectar, juice, ready-todrink tea, jam, barbecue sauce, tomato sauce, instant juice and instant pudding), presenting good resolution, rapid analysis (11 min) and low use of reagents. This indicates that the UPLC is an excellent alternative for the simultaneous analysis of artificial sweeteners in foods.

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“…A disadvantage of LC‐MS is that these separations usually involve long analysis times, large volume of toxic organic solvents, and a complex and expensive instrumentation. Conventional CE has also been employed for separation and determination of phenolic compounds in beverages and food matrixes, with UV–Vis absorption detectors being employed for most studies . However, analogous to the chromatographic separations, these CE‐based assays often require long analysis times, in the order of several minutes and do not offer portability.…”

Section: Introductionmentioning

confidence: 99%

Separation of natural antioxidants using PDMS electrophoresis microchips coupled with amperometric detection and reverse polarity

et al. 2014

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This report describes the use of PDMS ME coupled with amperometric detection for rapid separation of ascorbic, gallic , ferulic, p‐coumaric acids using reverse polarity. ME devices were fabricated in PDMS by soft lithography and detection was accomplished using an integrated carbon fiber working electrode aligned in the end‐channel configuration. Separation and detection parameters were investigated and the best conditions were obtained using a run buffer consisting of 5 mM phosphate buffer (pH 6.9) and a detection voltage of 1.0 V versus Ag/AgCl reference electrode. All compounds were separated within 70 s using gated injection mode with baseline resolution and separation efficiencies between 1200 and 9000 plates. Calibration curves exhibited good linearity and the LODs achieved ranged from 1.7 to 9.7 μM. The precision for migration time and peak height provided maximum values of 4% for the intrachip studies. Lastly, the analytical method was successfully applied for the analysis of ascorbic and gallic acids in commercial beverage samples. The results achieved using ME coupled with amperometric detection were in good agreement with the values provided by the supplier. Based on the data reported here, the proposed method shows suitability to be applied for the routine analysis of beverage samples.

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Doehlert design-desirability function multi-criteria optimal separation of 17 phenolic compounds from extra-virgin olive oil by capillary zone electrophoresis

Cited by 28 publications

References 32 publications

Development of a method for simultaneous analysis of caffeine and taurine in energy drinks by micellar electrokinetic chromatography with diode-array detector

Development of a method for simultaneous analysis of caffeine and taurine in energy drinks by micellar electrokinetic chromatography with diode-array detector

Multivariate Optimisation and Validation of a Method for the Separation of Five Artificial Sweeteners by UPLC-DAD in Nine Food Matrices

Separation of natural antioxidants using PDMS electrophoresis microchips coupled with amperometric detection and reverse polarity

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