Doege-Potter syndrome and ‘big-IGF2’: a rare cause of hypoglycaemia

Fung, En C.; Crook, Martin

doi:10.1258/acb.2011.011020

Cited by 25 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For diagnosis, it must be taken into account that IGF-2 tests tend to be normal; due to the fact that it does not exist any patented way of testing for the IGF-2 parahormone (at high levels in these cases), the increase in the IGF-2/IGF-1 ratio is used as guidance for diagnosis. This occurs because the high levels of the IGF-2 special form produced by the tumor contribute to decrease the levels of IGF-1 by negative feedback, producing an increase in the IGF-2/IGF-1 ratio [8,9].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Urinary Bladder Associated with Hypoglycemia: An Unusual Case of Doege-Potter Syndrome

et al. 2019

View full text Add to dashboard Cite

Solitary fibrous tumors (SFT) are rare mesenchymal tumors, mostly benign. Less than 30 cases have been described for the urinary bladder, 2 of them malignant. These lesions show infrequent clinical and radiological usual features, making the diagnosis difficult. Therefore, an immunohistochemical and morphological comprehensive study, which will provide the main prognostic factors, is necessary for histological diagnosis. The hypoinsulinemic hypoglycemia, as a paraneoplastic syndrome associated with SFTs – also known as the Doege-Potter Syndrome – is an infrequent finding, and quite incidental when located in the bladder. In order to obtain a fair oncological result, the recommended procedure for this type of tumors is surgical exeresis with negative margins, including non-standardized chemotherapy/radiotherapy as an alternative treatment.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Urinary Bladder Associated with Hypoglycemia: An Unusual Case of Doege-Potter Syndrome

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It can happen with SFTs arising in all sites. Hypoglycemia can occur due to tumor secretion of large insulin-like growth factor II (IGF2) [10]. …”

Section: Discussionmentioning

confidence: 99%

Giant Perineal Solitary Fibrous Tumor: A Rare Case Report

Melo

Bonifaci

Crochik

et al. 2017

Case Reports in Urology

View full text Add to dashboard Cite

Background. Solitary fibrous tumor (SFT) is a fibroblastic mesenchymal tumor that was initially described from the pleura but currently arises at almost every anatomic site. It is usually benign, and surgical resection is curative. SFT involving the perineum is extremely rare. This is the third case report of a perineal SFT in the literature. Case Presentation. We reported an uncommon case of a 64-year-old man presenting with a huge perineal mass that started growing 3 years before his arrival in our service. He was asymptomatic. A contrast-enhanced CT scan revealed a heterogeneous well-circumscribed perineal mass with soft-tissue density. Invasion of the surrounding organs, distal metastasis, and lymph node swelling were absent. The complete resection of mass was done successfully. The specimen was a 23.0 × 14.0 × 8.0 cm encapsulated tumor. Mass weight was 1,170 g. After pathological analysis, we confirmed that the mass was a solitary fibrous tumor. The diagnosis was based on clinical findings and histological morphology and immunohistochemistry study. Conclusion. SFTs are usually indolent tumors with a favorable prognosis. The perineal location is extremely rare. Complete resection of the mass is the treatment of choice.

show abstract

“…El SDP es poco frecuente, en la mayoría de los casos ha sido asociado a tumores fi brosos intratorácicos, aunque también se ha asociado a otro tipo de tumores intratorácicos y a tumores fi brosos extratorácicos [1][2][3][4]14 . Como factores responsables de la hipoglicemia en el SDP se han postulado varias teorías: secreción excesiva por el tumor de IGF-II (Factor de crecimiento similar a la insulina), falla en los mecanismos compensadores para prevenir la hipoglicemia y acelerado consumo de glucosa por tumores de gran tamaño 1,2,[14][15][16][17] . La hipoglicemia se ha comunicado en pacientes que presentaron concomitantemente un aumento de IGF-II.…”

Section: Discussionunclassified

Síndrome de Doege-Potter: hipoglicemia secundaria a tumor fibroso solitario de la pleura

F³

et al. 2012

Rev. méd. Chile

View full text Add to dashboard Cite

Doege-Potter syndrome: hypoglycemia secondary to solitary fi brous tumor of the pleura.Report of one case E l síndrome de Doege-Potter (SDP) es un sín-drome paraneoplásico infrecuente, consiste en la presencia de hipoglicemia sintomática asociada generalmente a un tumor fi broso solitario de la pleura (TFSP), aunque ha sido asociado a otros tumores intratorácicos y a tumores fi brosos en otras localizaciones [1][2][3][4] . Fue descrito en forma separada por Karl Doege y Roy Potter en 1930, en un paciente con un tumor fi broso en el mediastino que presentó hipoglicemia 5,6 . El TFSP es una neoplasia infrecuente, se presenta generalmente en relación a la pleura visceral y representa menos de 5% de los tumores pleurales. Una manifestación infrecuente en estos pacientes es la hipoglicemia, que se presenta sólo entre 2-3% de los casos 7,8 . Presentamos el caso de una paciente con SDP en que la hipoglicemia sintomática se asoció a un tumor fi broso solitario de la pleura. Caso clínicoMujer de 38 años, domiciliada en sector rural y sin antecedentes mórbidos conocidos. Inició cuadro clínico caracterizado por deterioro del estado general, baja de peso (aproximadamente 10 kg en tres meses) y edema de extremidades inferiores.Consultó en varias oportunidades en el centro de salud rural de su sector donde se trató en forma sintomática. Presentó un episodio de hipoglicemia (26 mg/dl) que se trató con infusión de solución glucosada al 10%. Evolucionó con normalización de la glicemia y fue trasladada a nuestro hospital.En la radiografía de tórax se observó una ocupación pleural derecha y desviación de las estructuras mediastínicas (Figura 1A). En la tomografía computada de tórax se observó un tumor pleural derecho, con densidad heterogénea, que ocupaba el hemitórax derecho con efecto compresivo, atelectasia pulmonar derecha y desplazamiento del mediastino ( Figura 1B, 1C y 1D). En los otros exámenes de laboratorio y de imagen no destacaron otros hallazgos signifi cativos.Durante la hospitalización presentó varios episodios de hipoglicemia sintomática caracterizada por somnolencia, deterioro de la agudeza visual,

show abstract

Doege-Potter syndrome and ‘big-IGF2’: a rare cause of hypoglycaemia

Cited by 25 publications

References 13 publications

Solitary Fibrous Tumor of the Urinary Bladder Associated with Hypoglycemia: An Unusual Case of Doege-Potter Syndrome

Solitary Fibrous Tumor of the Urinary Bladder Associated with Hypoglycemia: An Unusual Case of Doege-Potter Syndrome

Giant Perineal Solitary Fibrous Tumor: A Rare Case Report

Síndrome de Doege-Potter: hipoglicemia secundaria a tumor fibroso solitario de la pleura

Contact Info

Product

Resources

About