Documento de consenso de GeSIDA/Plan Nacional sobre el Sida respecto al tratamiento antirretroviral en adultos infectados por el virus de la inmunodeficiencia humana (actualización enero 2013)

doi:10.1016/j.eimc.2013.04.009

Cited by 3 publications

(1 citation statement)

References 751 publications

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“…Firstly, the criteria for HAART initiation have not always been the same; they change over our study period. For example, the criteria for HAART initiation in 2013 in Spain was having a CD4 count of < 500 cells/μL in asymptomatic patients or presenting an AIDS-defining illness [ 65 ]. This means that for our survey and according to CD4 counts, 1680 patients (65.1% of the subjects with CD4 known values) should have started HAART shortly after knowing their HIV diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort

et al. 2015

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IntroductionAntiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013.Materials and MethodsWe followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models.Mortality Results182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0–16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7–6.1/1000 py), external was lower [1.7/1000 py; (1.0–2.4/1000 py)].Survival ResultsKaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5–7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3–5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4–1.7) and heterosexual female (sHR:2.8; CI:1.1–7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7–123.2) and heterosexual male (sHR:11.8; CI:2.5–56.4) versus MSM.Conclusion and RecommendationThere are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males.

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Section: Discussionmentioning

confidence: 99%

Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort

et al. 2015

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Infección por el VIH (I)

León-Naranjo

2014

Medicine - Programa de Formación Médica Continuada Acreditado

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Predictors of primary non-adherence to concomitant chronic treatment in HIV-infected patients with antiretroviral therapy

et al. 2017

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ObjectivesTo identify the independent risk factors of primary non-adherence to chronic concomitant treatment in HIV-positive patients, and to measure primary and secondary non-adherence rates to chronic treatments, and secondary non-adherence to antiretroviral therapy and the prevalence of concomitant chronic diseases.MethodsWe conducted a retrospective study that included HIV-infected patients with antiretroviral treatmentwho attended the pharmaceutical care office between January and December 2012. The dependent variable was primary non-adherence to concomitant prescription drugs for chronic diseases. To know the predictors of concomitant primary non-adherence, we performed a univariate analysis and a multivariate binary logistic regression model to identify the independent predictors of primary non-adherence to co-medication.ResultsOut of 598 patients analysed, 333 patients had a new co-medication prescribed during the studied period. The number of comorbidities per patient was 2.3 and the patients were treated with an average of 3.4 drugs. The rates of primary and secondary non-adherence to co-medication were 8.4% and 44.4%, respectively. The co-occurrence of primary and secondary non-adherence was 24.9%. The number of comorbidities (p=0.001) and co-medications (p=0.001) was significantly higher in patients who had primary non-adherence to co-medication. Furthermore, there was a statistically significant relationship between primary non-adherence and patients treated with psychotropic drugs (p=0.03). The multivariate analysis showed the independent predictor of primary non-adherence to co-medication was the number of co-medications (p<0.001).ConclusionOne-third of new concomitant medications prescribed to HIV-positive patients were never filled from the pharmacy. The number of co-medications was identified as a predictor of primary non-adherence to chronic concomitant treatment in HIV-infected population.

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Documento de consenso de GeSIDA/Plan Nacional sobre el Sida respecto al tratamiento antirretroviral en adultos infectados por el virus de la inmunodeficiencia humana (actualización enero 2013)

Cited by 3 publications

References 751 publications

Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort

Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort

Infección por el VIH (I)

Predictors of primary non-adherence to concomitant chronic treatment in HIV-infected patients with antiretroviral therapy

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