Docosahexaenoic Acid Alleviates Atopic Dermatitis in Mice by Generating T Regulatory Cells and M2 Macrophages

Haitz, Karyn; Anandasabapathy, Niroshana

doi:10.1038/jid.2014.536

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…These effects were abolished when GPR40 was blocked [49] or PPARγ was silenced [29]. Omega-3-induced polarization of macrophages towards an M2 phenotype has been successfully employed to reduce brain injury upon stroke [50] and alleviate atopic dermatitis [51].…”

Section: Effects Of Omega-3 Fatty Acids On Macrophage Functionmentioning

confidence: 99%

Effects of Omega-3 Fatty Acids on Immune Cells

Gutiérrez

Svahn

Johansson

2019

IJMS

397

301

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Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although the mechanisms for such regulation are diverse. First, as a constitutive part of the cellular membrane, omega-3 fatty acids can regulate cellular membrane properties, such as membrane fluidity or complex assembly in lipid rafts. In recent years, however, a new role for omega-3 fatty acids and their derivatives as signaling molecules has emerged. In this review, we describe the latest findings describing the effects of omega-3 fatty acids on different cells from the immune system and their possible molecular mechanisms.

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Section: Effects Of Omega-3 Fatty Acids On Macrophage Functionmentioning

confidence: 99%

Effects of Omega-3 Fatty Acids on Immune Cells

Gutiérrez

Svahn

Johansson

2019

IJMS

397

301

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“…An additional murine strain, termed hairless mice, develops AD‐like features when fed an unsaturated fatty acid deficient diet, which are reversed by supplementation with LA, ALA, GLA, and AA . DHA suppressed the development of hapten‐induced dermatitis in mouse models by reducing serum IgE, histamine production, ear thickness, and lymph node size, associated with increased CTLA4+ regulatory T cells . Similarly, fish oil feeding to rats reduced transepidermal water loss, increased skin hydration, alleviated the acetone induced skin barrier alteration, and eliminated itch‐related scratching induced by dry skin .…”

Section: Animal Modelsmentioning

confidence: 99%

EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis

Venter

Meyer

Nwaru

et al. 2019

Allergy

118

154

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The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review.The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time.Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis. K E Y W O R D Sasthma, atopic dermatitis, food allergy, nutrition, rhinitis

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“…AD patients exhibit a mixed Th1/Th2 phenotype, and it is not surprising that mixed phenotype macrophages (M1/M2) were observed in AD [ 13 ]. Macrophages are known to accumulate rapidly and chronically in AD inflamed skin [ 12 , 47 ]. M1 macrophages predominate during the early stage of inflammation, which mediate pathogen clearance and recruitment of other effector cells, while M2 macrophages prevail toward the end of inflammation [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation

Zeng

Liu

Xing

et al. 2020

Mediators of Inflammation

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Atopic dermatitis (AD) is a relapsing, acute, and chronic skin disease featured by intractable itching, eczematous skin. Conventional therapies based on immunosuppression such as corticosteroids are associated with multiple adverse reactions. Periploca forrestii Schltr saponin (PFS) was shown to potently inhibit murine arthritis by protecting bone and cartilage injury and suppressing NF-κB activation. However, its therapeutic effect on oxazolone-induced atopic dermatitis (AD) and the underlying mechanisms on macrophage are still unclear. The AD-like dermatitis was induced by repeated oxazolone challenge to the skin of BALB/c mice in vivo. Blood and ears were biochemically or histologically processed. RT-PCR, western blotting, and ELISA were conducted to evaluate the expression of macrophage factors. Mouse bone marrow-derived macrophages (BMDMs) stimulated with lipopolysaccharide (LPS) were used as a model in vitro. PFS treatment inhibited AD-like dermatitis development. PFS downregulated epidermis thickness and cell infiltration, with histological analysis of the skin lesion. PFS alleviated plasma immunoglobulin (Ig) E, IgG2a, and IgG1 levels. PFS downregulated the expression of M1 macrophage factors, tumor necrosis factor- (TNF-) α, interleukin- (IL-) 6, monocyte chemotactic protein-1 (MCP-1), and nitric oxide synthase2 (NOS2), and M2 macrophage factors, IL-4, arginase1 (Arg1) and CD163 in AD-like skin, which were confirmed by western blot and ELISA analysis. In addition, PFS inhibited LPS-induced macrophage polarization via the inhibition of the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and nuclear translocation of NF-κB p65. These results suggest that PFS exerted an antidermatitis effect against oxazolone by modulating macrophage activation. PFS administration might be useful in the treatment of AD and inflammatory skin diseases.

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Docosahexaenoic Acid Alleviates Atopic Dermatitis in Mice by Generating T Regulatory Cells and M2 Macrophages

Cited by 13 publications

References 23 publications

Effects of Omega-3 Fatty Acids on Immune Cells

Effects of Omega-3 Fatty Acids on Immune Cells

EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis

Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation

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